Biotechnology Journal,
Год журнала:
2024,
Номер
19(12)
Опубликована: Дек. 1, 2024
ABSTRACT
Ultrasound
(US)
can
easily
penetrate
media
with
excellent
spatial
precision
corresponding
to
its
wavelength.
Naturally,
US
plays
a
pivotal
role
in
the
echolocation
abilities
of
certain
mammals
such
as
bats
and
dolphins.
In
addition,
medical
generated
by
transducers
interact
tissues
via
delivering
ultrasonic
energy
modes
heat
generation,
exertion
acoustic
radiation
force
(ARF),
cavitation.
Based
on
principle
echolocation,
various
assistive
devices
for
visual
impairment
people
have
been
developed.
High‐Intensity
Focused
(HIFU)
are
developed
targeted
ablation
tissue
destruction.
Besides
thermal
ablation,
histotripsy
is
designed
damage
purely
mechanical
effect
without
coagulation.
Low‐Intensity
(LIFU)
has
proven
be
an
effective
stimulation
method
neuromodulation.
Furthermore,
reported
transiently
increase
permeability
biological
membranes,
enabling
transfection
blood‐brain
barrier
open.
All
these
advances
changing
clinic.
This
review
mainly
introduces
aspects,
focusing
physical
principles,
challenges,
future
direction.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Abstract
Sonodynamic
therapy
(SDT)
is
a
non‐invasive,
non‐toxic
technique
that
shows
strong
potential
for
tumor
treatment:
however,
its
application
limited
by
lack
of
efficient
sonosensitizers,
insufficient
oxygen
supply,
and
high
levels
glutathione
(GSH)
in
tumors.
In
this
study,
nanosonosensitizer,
single‐atom
W
anchored
hexagonal
boron
nitride@ferrihydrite@trisulfide
bond‐modified
carboxymethyl
chitosan
(W‐BN@Fht@TSCM)
nanocomplex,
developed
exhibits
an
sonosensitizing
effect
microenvironment
remodeling
ability,
thereby
enhancing
SDT.
W‐BN
prepared
anchoring
monatomic
onto
the
surface
nitride
(h‐BN)
nanosheets,
which
exhibit
superior
piezoelectric
response
to
h‐BN
owing
breaking
lattice
symmetry.
This
excellent
facilitates
production
more
reactive
species
under
ultrasound
conditions.
Moreover,
H
2
O
decomposed
Fht
nanoparticles,
serve
as
catalase‐like
nanoenzymes,
alleviating
hypoxia
providing
sufficient
substrates.
Additionally,
TSCM,
provides
three
unique
redox
sites
potential,
rapidly
efficiently
consumes
GSH,
weakens
antioxidant
defense
mechanism
cells
enhances
efficacy
Improving
material
while
demonstrates
therapeutic
effects
reference
design
SDT
nanosystems.
Nano-Micro Letters,
Год журнала:
2025,
Номер
17(1)
Опубликована: Фев. 24, 2025
Abstract
Sonodynamic
therapy
(SDT)
as
an
emerging
modality
for
malignant
tumors
mainly
involves
in
sonosensitizers
and
low-intensity
ultrasound
(US),
which
can
safely
penetrate
the
tissue
without
significant
attenuation.
SDT
not
only
has
advantages
including
high
precision,
non-invasiveness,
minimal
side
effects,
but
also
overcomes
limitation
of
low
penetration
light
to
deep
tumors.
The
cytotoxic
reactive
oxygen
species
be
produced
by
utilization
combined
with
US
kill
tumor
cells.
However,
underlying
mechanism
been
elucidated,
its
unsatisfactory
efficiency
retards
further
clinical
application.
Herein,
we
shed
on
main
mechanisms
types
sonosensitizers,
organic
inorganic
sonosensitizers.
Due
development
nanotechnology,
many
novel
nanoplatforms
are
utilized
this
arisen
field
solve
barriers
enable
continuous
innovation.
This
review
highlights
potential
nanosonosensitizers
focus
enhanced
based
monotherapy
or
synergistic
that
difficult
reach
traditional
treatment,
especially
orthotopic
cancers.
ABSTRACT
Sonodynamic
therapy
(SDT)
is
an
innovative
cancer
modality
that
harnesses
the
energy
of
ultrasound
to
activate
sonosensitizers
for
producing
reactive
oxygen
species
(ROS),
culminating
in
eradication
tumor
cells.
Compared
with
photodynamic
therapy,
SDT
has
capacity
penetrate
deeply
into
biological
tissues,
thereby
holding
significant
promise
addressing
situated
or
surgically
inaccessible
tumors.
The
effectiveness
greatly
dependent
on
characteristics
sonosensitizers,
and
unlike
inorganic
organic
offer
a
more
controlled
synthesis
process
have
excellent
biocompatibility.
This
review
presents
meticulous
undertaking
categorize
elucidate
their
mechanisms
action
therapeutic
effects
context
SDT.
Design
strategies
are
also
summarized,
we
emphasize
critical
role
nanotechnology
localization,
imaging,
multimodal
synergistic
offering
approach
achieving
precise
targeting.
In
addition,
impact
delineated
when
integrated
other
oncological
modalities,
such
as
photothermal
enhance
efficacy.
Finally,
discusses
challenges
future
perspectives
advancement
clinical
within
realm
oncology.
Small Structures,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
As
two
main
phototherapy
means,
photodynamic
therapy
(PDT)
and
photothermal
(PTT)
have
different
photon‐transition
avenues
decided
by
the
aggregation
state
of
photosensitizers
(PSs),
thus
PDT
or
PTT
efficiency
can
be
regulated
regulating
PSs
aggregation.
A
co‐assembly
formulation
consisting
IR780
iodide
pentafluorophenyl
trifluoroacetate
is
constructed
through
intermolecular
interactions,
followed
coating
with
hyaluronic
acid.
Initially,
uniform
distribution
favors
more
reactive
oxygen
species
birth
to
implement
when
entering
cells
since
its
avenue
sequential
process
intersystem
crossing
transfer–collision
energy
transfer
predominant.
After
hyaluronidase
laser
irradiation‐induced
structural
collapse
co‐assembly,
free
aggregates
due
hydrophobic
interactions
even
though
they
are
excreted
out
cells,
then,
these
produce
heat
nonradiative
relaxation
execute
PTT.
Such
a
spatiotemporal
PDT–PTT
encourages
antitumor
immune
responses
mitigates
immunosuppression,
accomplishing
photoimmunotherapy
against
breast
cancer
progression.
Through
such
tumor
microenvironment‐adaptable
laser‐duration‐decided
alteration,
switching
insights
provided
into
single
PSs‐mediated
photoimmunotherapy.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(43), С. 58357 - 58369
Опубликована: Окт. 16, 2024
Sonodynamic
therapy
(SDT)
is
a
promising
treatment
modality
for
breast
cancer;
however,
its
effectiveness
often
impeded
by
the
hypoxic
tumor
microenvironment
owing
to
an
insufficient
oxygen
supply
in
solid
tumors.
To
overcome
this
challenge,
we
elaborately
developed
4T1
tumor-targeted
multifunctional
nanoagent
integrating
both
dendrimer-structured
copper
chelating
agents
and
organic
sonosensitizers
(IR820)
into
biotin-modified
nanoliposome
via
microfluidic-assisted
self-assembly.
In
particular,
aforementioned
agent
was
constructed
introducing
multiple
xanthate
groups
dendrimer
polymer,
which
showed
significant
selectivity
consumption
of
intracellular
levels.
Based
on
this,
nanoliposome-based
therapeutic
not
only
disrupted
activity
mitochondrial
complex
IV
directly
inhibit
cell
proliferation
but
also
suppressed
resistance
SDT
inhibition
cellular
respiration.
Both
vitro
vivo
studies
confirmed
that
designed
nanoagents
exhibit
synergistic
effect
IR820-mediated
SDT.
Taken
together,
approach
establishes
proof-of-concept
construction
copper-ion-modulated
nanomedicine
significantly
enhance
efficiency
oxygen-dependent
cancer
treatments.
Ultrasonics Sonochemistry,
Год журнала:
2024,
Номер
107, С. 106928 - 106928
Опубликована: Май 27, 2024
Rheumatoid
arthritis
(RA)
is
a
chronic
systemic
inflammatory
disease
characterized
by
infiltration
of
cells,
hyperplasia
synovium,
and
destruction
the
joint
cartilage.
Owing
to
low
drug
delivery
efficiency
limited
immunosuppression
effect,
complete
cure
for
RA
remains
formidable
challenge.
Here,
we
show
that
live
macrophages
(Mφs)
carrying
protoporphyrin-loaded
Fe
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 14, 2024
Abstract
Tirapazamine
(TPZ),
an
antitumor
prodrug,
can
be
activated
in
hypoxic
environment.
It
specifically
targets
the
microenvironment
of
tumors
and
produces
toxic
free
radicals.
However,
due
to
tumor
is
not
completely
hypoxic,
TPZ
often
fails
effectively
treat
entire
tissue,
resulting
suboptimal
therapeutic
outcomes.
Herein,
a
low
pathogenic
Escherichia
coli
TOP10
utilized
selectively
colonize
tissues,
disrupt
blood
vessels,
induce
thrombus
formation,
leading
expansion
region
improving
effect
TPZ.
Additionally,
thermosensitive
hydrogel
constructed
by
Pluronic
F‐127
(F127),
which
undergoes
gelation
situ
at
site,
sustained
release
To
monitor
process,
it
genetically
modified
integrating
bioluminescent
system
luxCDABE
(TOP10‐Lux).
The
signal
associated
with
hypoxia
enhancement
beneficial
for
monitoring
bioluminescence
imaging.
In
murine
colon
cancer
model,
TOP10‐Lux
combined
TPZ‐loaded
F127
suppressed
growth,
treatment
process
efficiently
monitored.
Together,
this
work
employs
enhance
efficacy
providing
effective
strategy
bacteria‐based
tumor‐targeted
chemotherapy
monitoring.
