Microbiological Research, Год журнала: 2024, Номер 292, С. 127987 - 127987
Опубликована: Ноя. 30, 2024
Язык: Английский
ACS Applied Nano Materials, Год журнала: 2024, Номер 7(15), С. 17707 - 17718
Опубликована: Июль 25, 2024
Wound-associated infections represent an arduous global healthcare challenge, especially in the "post-antibiotic" era, necessitating development of advanced antimicrobial dressing materials that simultaneously dictate use rapid yet effective disinfection, low drug resistance and side effects, potency to foster tissue healing. Nanoantimicrobial-armored nanostructured functional systems have piqued extensive interest satisfy these criteria. Herein, fusing electrospinning nanotechnology emerging photo–chemo synergistic sterilization paradigm, a smart "all-in-one" multifunctional wound-managing platform was constructed, through incorporating photochemically active nanocrystalline cuprous oxide (Cu2O) into modified polycaprolactone (mPCL) electrospun fibrous mats. The resulting were systematically characterized pertaining physiochemical analysis, photoabsorption photocurrent measurements, photocatalytic reactive oxygen species (ROS) generation. capability this nanoplatform elicit rapid, photoactivated, catalytically augmented bacterial disinfection corroborated, displaying ∼99–100% broad-spectrum antibacterial efficacies against Staphylococcus aureus Escherichia coli 25 min. Benefiting from release Cu2+, mPCL-Cu2O impairs contamination even under dark conditions. Furthermore, also exhibited favorable vitro/-ovo biocompatibility toward NIH3T3 fibroblasts, red blood cells, chick chorioallantoic membrane, alongside appreciable pro-healing capacity bridging scratch-based wounds, which could be attributed nanofiber-afforded biomimetic topography controllable liberation micronutrient Cu ions. This study provides insights design fabrication simple nanoplatforms for biomedical applications.
Язык: Английский
Процитировано
8
Journal of Controlled Release, Год журнала: 2025, Номер 378, С. 1045 - 1060
Опубликована: Янв. 5, 2025
Язык: Английский
Процитировано
1
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 20, 2025
Abstract Infectious diabetic wounds pose an arduous threat to contemporary healthcare. The combination of refractory biofilms, persistent inflammation, and retarded angiogenesis can procure non‐unions life‐threatening complications, calling for advanced therapeutics potent orchestrate anti‐infective effectiveness, benign biocompatibility, pro‐reparative immunomodulation, angiogenic regeneration. Herein, embracing the emergent “living bacterial therapy” paradigm, a designer probiotic‐in‐hydrogel wound dressing platform is demonstrated. constructed employing “macrogel/microgel/biofilm” hierarchical encapsulation strategy, with Lactobacillus casei as model probiotic. Alginate gels, in both macro micro forms, along self‐produced probiotic served encapsulating agents. Specifically, live probiotics are enclosed within alginate microspheres, embedded into bulk matrix, cultivated facilitate biofilm self‐encasing. This multiscale confinement protected averted their inadvertent escape, while enabling sustained secretion, proper reservation, localized delivery therapeutically active metabolites, such lactic acid. resulting biosystem, validated vitro/ovo/vivo, elicited well‐balanced antibacterial activities biological compatibility, alongside prominent pro‐healing, vasculogenic anti‐inflammatory potencies, thus accelerating regeneration infected full‐thickness excisional mice. Such multiple encapsulation‐engineered “all‐in‐one” tactic may shed new light on safe efficient adoption bacteria treating chronic infectious diseases.
Язык: Английский
Процитировано
1
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101553 - 101553
Опубликована: Фев. 5, 2025
Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with increasing prevalence antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due limited penetration, resistance development, and inadequate local concentration at wound sites. These limitations necessitate exploration alternative strategies that can overcome drawbacks conventional therapies. Nanomaterials have emerged as promising solution for tackling bacterial infections facilitating healing, thanks their distinct physicochemical characteristics multifunctional capabilities. This review highlights latest developments nanomaterials demonstrated enhanced antibacterial efficacy improved healing outcomes. The mechanisms are varied, including ion release, chemodynamic therapy, photothermal/photodynamic electrostatic interactions, delivery drugs, which not only combat but also address challenges posed biofilms antibiotic resistance. Furthermore, these create an optimal environment tissue regeneration, promoting faster closure. By leveraging unique attributes nanomaterials, there is significant opportunity revolutionize management wounds markedly improve patient
Язык: Английский
Процитировано
0
RSC Advances, Год журнала: 2025, Номер 15(5), С. 3439 - 3447
Опубликована: Янв. 1, 2025
SeTe–ZnO NP with dual photodynamic and photothermal properties were synthesized for antibacterial wound healing.
Язык: Английский
Процитировано
0
Small Structures, Год журнала: 2025, Номер unknown
Опубликована: Фев. 5, 2025
Tumors endanger the lives of individuals worldwide. They form and metastatize to nearby distant tissues organs in several ways, which greatly increase difficulty therapy. The continuous development progress nanomedicine has provided new insights treatment tumors. Owing their excellent properties barium titanate (BaTiO 3 , BTO), especially piezoelectricity, BTO‐based nanomaterials have become popular among tumor therapy researchers recent years. sonodynamic (SDT) is considerably advanced than traditional therapies. Herein, first, properties, structure, preparation technology, working mechanism BTO under ultrasonic stimulation systematically introduced. Second, research BTO‐mediated SDT, electrical therapy, SDT‐derived multimodal synergistic field reviewed. Third, biocompatibility, biodistribution, bioelimination summarized. Finally, current problems associated with SDT as well potential obstacles opportunities oncology other biomedical fields are summarized prospected.
Язык: Английский
Процитировано
0
ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Фев. 17, 2025
The increasing prevalence of multidrug-resistant bacteria is a significant global health threat. In contrast to conventional antibiotic treatments, photodynamic therapy (PDT) offers promising alternative by reducing the bacterial adaptability antibiotics and bactericides. However, traditional photosensitizers encounter poor antimicrobial efficacy due hydrophilicity photosensitizers, short lifespan, narrow diffusion radius reactive oxygen species (ROS), risk exacerbating inflammation. this study, we report bacterial-targeting supramolecular nanophotosensitizer for combating multidrug resistant bacteria. nanophotosensitizer, formed through host–guest interactions self-assembly tetra-cyclodextrin-modified silver porphyrin (AgTPP-CD4), adamantyl-modified phenylboronic acid (Ad-PBA), curcumin (Cur), can effectively target kill methicillin-resistant Staphylococcus aureus (MRSA). Moreover, it reduces inflammation promotes wound healing in MRSA-infected wounds without inducing drug resistance. combination chemistry targeted PDT strategy infections.
Язык: Английский
Процитировано
0
Small, Год журнала: 2025, Номер unknown
Опубликована: Фев. 21, 2025
Abstract Dynamic wound care presents significant challenges for conventional dressings due to the complex environment and high‐frequency motion associated with such injuries. In this study, a multifunctional photo‐crosslinked piezoelectric hydrogel (OAPS) is developed, incorporating heterojunction Se‐doped KH570 modified BaTiO 3 nanoparticles (Se‐BT570 NPs) as core component, designed address antimicrobial monitoring needs in care, particularly at sites movement. The OAPS effectively utilizes inherent dynamic wounds, enhancing efficacy enabling real‐time of human health statuses. This achieved through synergistic effects properties nano‐heterostructures that enable self‐driven charge transfer. Such integration allows dual applications both diagnosis treatment. Experimental results demonstrated exhibits excellent mechanical strength adhesive properties, adapting motion. Additionally, can be activated by environments perform functions, significantly accelerating healing an rate 99.75%. study highlights potential nanomaterials healing, offering promising strategy managing complex, care.
Язык: Английский
Процитировано
0
Inorganics, Год журнала: 2025, Номер 13(3), С. 71 - 71
Опубликована: Фев. 26, 2025
As a non-invasive modality, sonodynamic therapy (SDT) offers several advantages in cancer treatment, including deep tissue penetration and precise spatiotemporal control, resulting from the interplay between low-intensity ultrasound sonosensitizers. Piezoelectric materials, known for their remarkable capacity of interconversion mechanical electrical energy, have garnered considerable attention biomedical applications, which can serve as pivotal sonosensitizers SDT. These materials generate internal electric fields via ultrasound-induced deformation, modulates alteration charge carriers, thereby initiating surface redox reactions to reactive oxygen species (ROS) realizing therapeutic efficacy This review provides an in-depth exploration piezoelectric utilized SDT, with particular emphasis on recent innovations, elucidation underlying mechanisms, optimization strategies advanced materials. Furthermore, incorporation immunotherapy, photodynamic, chemodynamic, chemotherapy is explored, emphasizing potential enhance outcomes. By examining basic principles effect its contributions this sheds light promising applications oncology. It also highlights future directions improving these expanding clinical utility tumor therapy.
Язык: Английский
Процитировано
0
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 30, 2025
Abstract Traditional biomaterial development lacks systematicity and predictability, posing significant challenges in addressing the intricate engineering issues related to infections with drug‐resistant bacteria. The unprecedented ability of artificial intelligence (AI) manage complex systems offers a novel paradigm for materials development. However, no AI model currently guides antibacterial biomaterials based on an in‐depth understanding interplay between In this study, AI‐guided design platform (AMP‐hydrogel‐Designer) is developed generate biomaterials. This utilizes generative multi‐objective constrained optimization thiol‐containing high‐efficiency antimicrobial peptide (AMP), that functionally coupled hydrogel form network structure. Additionally, Cu‐modified barium titanate (Cu‐BTO) incorporated facilitate further cross–linking via Cu 2+ /SH coordination produce AI‐AMP‐hydrogel. vitro, AI‐AMP‐hydrogel exhibits > 99.99% bactericidal efficacy against Methicillin‐resistant Staphylococcus aureus (MRSA) Escherichia coli ( E. coli) . Furthermore, Cu‐BTO converts mechanical stimulation into electrical signals, thereby promoting expression growth factors angiogenesis. rat dynamic wounds, AI‐AMP significantly reduces MRSA load markedly accelerates wound healing. Therefore, strategy innovative solution precisely treat bacterial infections.
Язык: Английский
Процитировано
0