Microbiological Research, Год журнала: 2024, Номер 292, С. 127987 - 127987
Опубликована: Ноя. 30, 2024
Язык: Английский
Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123577 - 123577
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Biomaterials Advances, Год журнала: 2025, Номер unknown, С. 214307 - 214307
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(32)
Опубликована: Окт. 14, 2024
Abstract Chronic wounds are characterized by long‐term inflammation, including diabetic ulcers, traumatic etc., which provide an optimal environment for bacterial proliferation. At present, antibiotics the main clinical treatment method chronic wound infections. However, overuse of may accelerate emergence drug‐resistant bacteria, poses a significant threat to human health. Therefore, there is urgent need develop new therapeutic strategies Nanozyme‐based antimicrobial therapy (NABT) emerging strategy with broad‐spectrum activity and low drug resistance compared traditional antibiotics. NABT has shown great potential as catalyzing generation reactive oxygen species (ROS) its enzyme‐like catalytic properties, producing powerful bactericidal effect without developing resistance. cascade technology offers approach infection control, effectively improving efficacy activating cascades against cell membranes intracellular DNA while minimizing side effects. it worth noting that this still in early stages research. This article comprehensively reviews classification, current methods infection, different types nanozymes, application nanozyme reaction therapy, future challenges prospects.
Язык: Английский
Процитировано
2
Small, Год журнала: 2024, Номер 20(47)
Опубликована: Авг. 15, 2024
Abstract Nanotizing biosealant components offer a multitude of chemical functionalities for superior adhesion–cohesion, delivering unique properties comprehensive wound healing that are otherwise impossible to achieve using commercial variants. For the first time, two‐step controlled hydrothermal pyrolysis is reported nanotize dopamine, phloroglucinol, and glutaraldehyde into carbon dot (CD) be subsequently converted carbonized polymer (CPD) with gelatin as co‐substrate. Chemical crosslinking CD through Schiff base formation before second step ensures complex yet porous polymeric network. The retention indigenous substrates along preservation photoluminescence in CPD optical tracking achieved. A nanoformulation created tannic acid (TA) grafting evolving CPD‐TA nanoglue demonstrating ≈1.32 MPa strength lap shear tests conducted on porcine skin, surpassing traditional bioadhesives. uploaded insulin chosen cargo disbursal at site normal vitro diabetic models HEKa cells extraordinary biocompatibility. Most importantly, can generate reactive oxygen species (ROS) scavenge simultaneously under ambient conditions (23 W white LED or dark) on‐demand sterilization aiding recovery ROS scavenging.
Язык: Английский
Процитировано
2
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 135931 - 135931
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
1
Burns & Trauma, Год журнала: 2024, Номер 12
Опубликована: Янв. 1, 2024
Abstract Background Bacterial infection, tissue hypoxia and inflammatory response can hinder infected wound repair. This study aimed to develop a multifunctional specific therapeutic photo-activated release nanosystem [HMPB@MB@AuNPs@PMB@HA (HMAPH)] by loading photosensitizer methylene blue (MB) into hollow mesoporous Prussian nanostructures modifying the surface with gold particles, polymyxin B (PMB) hydrophilic hyaluronic acid. Methods The HMAPH was characterized using transmission electron microscopy, UV–vis, Fourier-transform infrared spectroscopy, X-ray diffraction photon spectroscopy. photothermal performance, iron ion free radical generation of were measured under different conditions investigate its thermo-responsive cascade reaction. antibacterial ability investigated live/dead fluorescence tests. morphology membrane integrity Pseudomonas aeruginosa (P. aeruginosa) microscopy. anti-biofilm activity evaluated crystal violet SYBR Green I staining. Finally, we established mouse model skin P. confirm in vivo effectiveness HMAPH. We used immunofluorescent staining, hematoxylin–eosin Masson staining enzyme-linked immunosorbent assay examine whether promoted healing reduced damage. Results In this study, acid decomposed action hyaluronidase. Also, exposed nanomaterials specifically bound outer through PMB increase sensitivity photodynamic treatment. Under dual-light irradiation, large amount ions released underwent Fenton reaction H2O2 bacteria generate hydroxyl radicals (•OH), enabling direct killing cells hyperthermia. Additionally, MB photo-induced activation led reactive oxygen species, achieving synergistic effective inhibition aeruginosa. also inhibited biofilm formation downregulated expression virulence factors. experiments revealed that accelerated aeruginosa-infected wounds promoting angiogenesis regeneration, inhibiting M1 M2 polarization. Conclusions Our proposed strategy against biofilms photothermal–photodynamic–Fenton reaction, opening up new prospects for combating biofilm-associated infections.
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 283, С. 137648 - 137648
Опубликована: Ноя. 14, 2024
Язык: Английский
Процитировано
1
Bioactive Materials, Год журнала: 2024, Номер 46, С. 173 - 194
Опубликована: Дек. 13, 2024
Язык: Английский
Процитировано
1
Carbohydrate Polymers, Год журнала: 2024, Номер 352, С. 123147 - 123147
Опубликована: Дек. 13, 2024
Язык: Английский
Процитировано
1
Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 158757 - 158757
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
1