Dendritic donor engineering to optimize second near-infrared photothermal agents for in situ photothermal therapy
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
689, С. 137190 - 137190
Опубликована: Март 7, 2025
Язык: Английский
Robust Luminescent Pyrene-Based Metal–Organic Framework Hydrogel as a pH-Responsive Fluorescence Emitter for Sensitive Immunoassay of Cardiac Troponin I
Analytical Chemistry,
Год журнала:
2024,
Номер
96(37), С. 15042 - 15049
Опубликована: Сен. 2, 2024
Despite
many
luminescent
advantages
including
outstanding
absorption
coefficient
and
high
quantum
yield,
pyrene
its
derivatives
have
been
suffering
from
a
dramatic
aggregation-caused
quenching
(ACQ)
effect.
Although
the
ACQ
effect
of
pyrene-based
fluorophores
has
restrained
in
pyrene-doped
metal-organic
frameworks
(MOFs),
low
loading
fluorescent
(FL)
units
substantially
impedes
improved
behaviors.
Herein,
MOFs
hydrogel
was
synthesized
with
as
unique
organic
linker
blocks
instead
dopant
MOFs.
The
gel
matrix
contributed
to
rigidifying
location
FL
emitters
achieving
intensive
emission
stability
therefore
efficiently
overcoming
Furthermore,
protonation
remarkably
decreased
intensity,
which
endowed
highly
pH-responsive
activity
broad
range
(pH
4-10).
Interestingly,
glucose
oxidase
immobilized
into
ZIF-8
efficient
quencher,
catalyzing
form
gluconic
acid
thus
drastically
signal
hydrogel.
emitter-quencher
pair
successfully
employed
develop
an
ultrasensitive
immunoassay
platform
for
cardiac
troponin
I
(as
model
analyte).
limit
detection
5.2
pg/mL
(3σ).
proof-of-principle
study
demonstrated
thrilling
auxiliary
tailorable
on
boosting
feasibility
aqueous
insoluble
chromophores
trace
analysis.
Язык: Английский
Naphthalimide‐Conjugated Spiropyran: Dual‐State Emission and Photo‐Responsive Dynamic Fluorescence Color for Information Encryption Application
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Abstract
Developing
photo‐switch
molecules
that
show
fluorescence
in
both
monomeric
and
aggregated
states,
with
light‐controllable
wavelength
is
far‐reaching
a
great
challenge.
Spiropyran
(SP)
has
received
considerable
attention
this
field.
Herein,
by
conjugating
naphthalimide
to
the
indole
moiety
of
SP,
new
spiropyran
derivative,
named
NMI‐SP
obtained.
shows
dual‐state
emission
excellent
its
attributed
intramolecular
charge
transfer
character.
Moreover,
demonstrates
obvious
photochromic
behavior,
accompanied
visible
color
change
from
yellow
green
THF
solution,
photo‐responsive
orange
red
state.
This
work
provides
insights
into
design
materials
based
on
SP
fluorophore
highlights
their
potential
applications
digital
coding
information
conversion.
Язык: Английский
Photo‐Amplified Plasma Membrane Rupture by Membrane‐Anchoring NIR‐II Small Molecule Design for Improved Cancer Photoimmunotherapy
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 4, 2024
Immunotherapy
is
a
promising
cancer
treatment
method
for
eradicating
tumor
cells
by
enhancing
the
immune
response.
However,
there
are
several
major
obstacles
to
conventional
phototherapy-mediated
responses,
including
inadequate
immunogenicity
and
immunosuppressive
environment.
Here,
we
present
novel
photoimmunotherapy
modality-the
development
of
membrane-anchoring
small
molecule
inducing
plasma
membrane
rupture
(PMR)
NIR-II
photo-stimulation,
thus
evoking
cell
necrotic
death
antitumor
immunotherapy.
Our
top-performing
(CBT-3)
exhibits
temperature-tunable
PMR
efficiency,
allowing
rapid
in
at
50
μM
dose
using
exogenous
light-mediated
mild
photothermal
effect
(1064
nm,
0.6
W
cm
Язык: Английский
Stimuli‐Responsive Polymers for Tubal Actuators
Chemistry - A European Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 27, 2024
Abstract
Stimuli‐responsive
polymers
for
tubal
actuators
have
garnered
significant
attention
due
to
their
potential
applications
in
soft
robotics,
artificial
blood
vessels,
controlled
liquid
transportation,
and
microchemical
reactors.
This
perspective
emphasizes
the
advantages,
response
mechanisms,
fundamental
design
principles
of
stimuli‐responsive
actuators.
It
also
addresses
biological
engineering
applications,
current
challenges,
future
prospects
The
discussion
categorizes
based
on
various
properties,
including
crystal
elastomer
actuators,
hydrogel
shape
memory
polymer
subsequent
sections
focuses
structural
features,
principles,
actuator,
elucidating
interrelationships.
molecular
architectures
are
intricately
linked
mechanisms.
Finally,
this
outlines
challenges
faced
by
article
aims
facilitate
broader
thereby
promoting
progress
across
multiple
fields.
Язык: Английский
Self‐Assembled Metal Complexes in Biomedical Research
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 23, 2024
Abstract
Cisplatin
is
widely
used
in
clinical
cancer
treatment;
however,
its
application
often
hindered
by
severe
side
effects,
particularly
inherent
or
acquired
resistance
of
target
cells.
To
address
these
challenges,
an
effective
strategy
to
modify
the
metal
core
complex
and
introduce
alternative
coordination
modes
valence
states,
leading
development
a
series
complexes,
such
as
platinum
(IV)
prodrugs
cyclometalated
complexes.
Recent
advances
nanotechnology
have
facilitated
multifunctional
nanomaterials
that
can
selectively
deliver
drugs
tumor
cells,
thereby
overcoming
pharmacological
limitations
metal‐based
drugs.
This
review
first
explores
self‐assembly
complexes
into
spherical,
linear,
irregular
nanoparticles
context
biomedical
applications.
The
mechanisms
underlying
are
subsequently
analyzed,
followed
discussion
their
applications
fields,
including
detection,
imaging,
antitumor
research.
Язык: Английский
Near-Infrared-II-Activated Transition Metal(II)-Coordinated Ligand Radical Primes Robust Anticancer Immunity
Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
67(23), С. 21329 - 21343
Опубликована: Ноя. 25, 2024
Photoactivatable
metallodrugs
combining
tumor
cell
eradication
and
immune
stimulation
hold
immense
promise
for
targeted
cancer
therapy.
However,
limitations
such
as
oxygen
dependence,
narrow
visible
light
responsiveness,
poor
immunogenicity
hinder
their
efficacy
in
deep
solid
tumors
with
hypoxic
immunosuppressive
microenvironments.
Herein,
we
present
a
novel
design
strategy
transition
metal(II)-coordinated
ligand
radicals
exhibiting
intense
near-infrared-II
(NIR-II)
absorption,
unique
endoplasmic
reticulum-targeting
capability,
oxygen-independent
photothermal
performance,
effectively
addressing
these
constraints.
Proof-of-concept
results
demonstrate
the
potent
of
our
cobalt(II)-coordinated
radical
(
Язык: Английский
Photo‐Amplified Plasma Membrane Rupture by Membrane‐Anchoring NIR‐II Small Molecule Design for Improved Cancer Photoimmunotherapy
Angewandte Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 4, 2024
Abstract
Immunotherapy
is
a
promising
cancer
treatment
method
for
eradicating
tumor
cells
by
enhancing
the
immune
response.
However,
there
are
several
major
obstacles
to
conventional
phototherapy‐mediated
responses,
including
inadequate
immunogenicity
and
immunosuppressive
environment.
Here,
we
present
novel
photoimmunotherapy
modality—the
development
of
membrane‐anchoring
small
molecule
inducing
plasma
membrane
rupture
(PMR)
NIR‐II
photo‐stimulation,
thus
evoking
cell
necrotic
death
antitumor
immunotherapy.
Our
top‐performing
(CBT‐3)
exhibits
temperature‐tunable
PMR
efficiency,
allowing
rapid
in
at
50
μM
dose
using
exogenous
light‐mediated
mild
photothermal
effect
(1064
nm,
0.6
W
cm
−2
).
Further
evidence
indicated
that
this
gentle
therapeutic
approach
activated
inflammatory
signaling
pathways
cells,
enhanced
immunogenic
death,
reshaped
microenvironment,
ultimately
promoting
systemic
responses
vivo.
This
study
represents
first
instance
utilizing
photo‐amplified
based
on
molecule,
providing
avenue
advancing
photoimmunotherapy.
Язык: Английский