ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Hydrogel
wound
dressings
have
emerged
as
a
promising
solution
for
healing
due
to
their
excellent
mechanical
and
biochemical
properties.
Over
recent
years,
there
has
been
significant
progress
in
expanding
the
variety
of
raw
materials
used
hydrogel
formulation
along
with
development
advanced
modification
techniques
design
approaches
that
enhance
performance.
However,
comprehensive
review
encompassing
diverse
polymer
strategies
innovations
is
still
lacking
literature.
This
summarizes
use
natural
polymers
(e.g.,
chitosan,
gelatin,
sodium
alginate,
hyaluronic
acid,
dextran)
synthetic
poly(vinyl
alcohol),
polyethylene
glycol,
Pluronic
F-127,
poly(N-isopropylacrylamide),
polyacrylamide,
polypeptides)
dressings.
We
further
explore
advantages
limitations
these
discuss
various
strategies,
including
cationic
modification,
oxidative
double-bond
catechol
etc.
The
also
addresses
principles
synthesis
methods,
aligning
modifications
specific
requirements
healing.
Finally,
we
future
challenges
opportunities
hydrogel-based
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 14, 2025
The
prevalence
of
heart
valve
disease
(HVD)
has
escalated
worldwide,
because
population
aging.
Currently,
artificial
replacement
is
considered
the
most
effective
treatment
for
HVD.
complexity
and
risk
have
been
markedly
reduced
with
development
minimally
invasive
interventional
techniques,
which
resulted
in
more
widespread
implantation
bioprosthetic
valves
(BHVs);
however,
they
still
present
defects
including
thrombosis,
poor
cytocompatibility,
immune
responses,
calcification,
reduces
their
service
life.
We
developed
a
microenvironment-responsive
zwitterionic
glycocalyx-mimetic
hydrogel-engineered
BHV
(Hes@HS-PP)
profile
on-demand
drug
release.
Inspired
by
structure
function
glycocalyx
on
inner
wall
blood
vessels,
hydrogel
coating
was
covalently
constructed
photoinduced
polymerization.
This
significantly
resisted
fouling
components
thrombosis
improved
endothelialization
potential
biocompatibility
BHVs
shielding
interactions
between
xenogeneic
collagenous
matrix.
Following
introduction
dynamic
borate
ester
bonds
into
hydrogel,
anti-inflammatory
hesperidin
(Hes)
loaded
onto
BHVs.
Excess
reactive
oxygen
species
were
scavenged,
Hes
released
inflammatory
region
demand
to
achieve
regulation
ameliorate
reactions
Moreover,
Hes@HS-PP
exhibited
lower
degree
calcification
rat
subcutaneous
model.
In
summary,
construction
hydrogels
enhanced
antithrombotic,
anti-inflammatory,
endothelialization,
anticalcification
properties
mitigated
structural
valvular
degradation,
offering
new
perspectives
functional
modification
ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Hydrogel
wound
dressings
have
emerged
as
a
promising
solution
for
healing
due
to
their
excellent
mechanical
and
biochemical
properties.
Over
recent
years,
there
has
been
significant
progress
in
expanding
the
variety
of
raw
materials
used
hydrogel
formulation
along
with
development
advanced
modification
techniques
design
approaches
that
enhance
performance.
However,
comprehensive
review
encompassing
diverse
polymer
strategies
innovations
is
still
lacking
literature.
This
summarizes
use
natural
polymers
(e.g.,
chitosan,
gelatin,
sodium
alginate,
hyaluronic
acid,
dextran)
synthetic
poly(vinyl
alcohol),
polyethylene
glycol,
Pluronic
F-127,
poly(N-isopropylacrylamide),
polyacrylamide,
polypeptides)
dressings.
We
further
explore
advantages
limitations
these
discuss
various
strategies,
including
cationic
modification,
oxidative
double-bond
catechol
etc.
The
also
addresses
principles
synthesis
methods,
aligning
modifications
specific
requirements
healing.
Finally,
we
future
challenges
opportunities
hydrogel-based
