Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 20, 2025
Abstract
Bacterial
infections
can
lead
to
severe
medical
complications,
including
major
incidents
and
even
death,
posing
a
significant
challenge
in
clinical
trauma
repair.
Consequently,
the
development
of
new,
efficient,
non‐resistant
antimicrobial
agents
has
become
priority
for
practitioners.
In
this
study,
stepwise
hydrothermal
reaction
strategy
is
utilized
prepare
Fe
3
O
4
@MoS
2
core–shell
nanoparticles
(NPs)
with
photosynthesis‐like
activity
treatment
bacterial
infections.
The
NPs
continuously
catalyze
production
reactive
oxygen
species
(ROS)
from
hydrogen
peroxide
through
reactions
convert
light
energy
into
heat
photothermal
efficiency
30.30%.
addition,
photosynthetically
generated
ROS,
combined
iron‐induced
cell
death
mechanism
NPs,
confer
them
exceptional
broad‐spectrum
antibacterial
properties,
achieving
activities
up
98.62%
Staphylococcus
aureus
,
99.22%
Escherichia
coli
98.55%
methicillin‐resistant
.
composite
exhibits
good
safety
hemocompatibility.
Finally,
full‐thickness
diabetic
wound
model
validates
pro‐healing
properties
chronic
wounds.
Overall,
design
photosynthesis‐inspired
presents
new
perspectives
developing
efficient
nano‐enzymatic
compounds,
offering
promising
solution
challenges
drug
resistance
antibiotic
misuse.
Diabetes
patients
suffer
from
severe
chronic
consequences
known
as
diabetic
foot
ulcers
(DFUs),
for
which
there
are
no
particular
therapy
options.
The
inflammatory
and
oxidative
microenvironments
in
DFUs
stimulate
the
secretion
of
high
mobility
group
box-1
(HMGB1),
binds
with
receptor
advanced
glycation
endproducts
(RAGE),
causing
cascade
reactions
immune
microenvironment
(IME)
disorder,
further
exacerbating
DFU
damage.
Strategies
targeting
HMGB1-RAGE
axis
to
end
this
vicious
loop
still
lacking.
This
study
proposes
a
novel
strategy
based
on
"breathable
hydrogels"
achieve
"head
tail"
co-blocking
regulate
IME
treatments.
Specifically,
palladium
hydride
(PdH)
nanocubes
functional
structure,
hydrogel
dressing
was
prepared
double
cross-linking
network
biocompatible
alginate
polyacrylamide
modified
trehalose
network-repairing
agent.
Mechanistically,
obtained
hydrogels
can
"inhale"
excess
accumulated
reactive
oxygen
species,
inhibiting
HMGB1
secretion,
"head"
axis.
Meanwhile,
H2
"exhaled"
suppress
expression
intracellular
RAGE,
thus
blocking
breaking
cycle.
proposed
offers
highly
efficient,
safe,
facile
therapeutic
protocol
DFUs.
Diabetic
wound
healing
remains
a
major
challenge
in
modern
medicine.
The
persistent
inflammation
and
immune
dysfunction
hinder
angiogenesis
by
producing
excessive
ROS
increasing
the
susceptibility
to
bacterial
infection.
In
this
study,
we
developed
an
integrated
strategy
for
whole-process
management
of
diabetic
wounds
based
on
bioinspired
adhesive
hydrogel
platform
with
hemostasis,
photothermal
antimicrobial,
antioxidant,
anti-inflammatory,
angiogenic
properties.
A
composite
(termed
AQTGF)
using
poly(acrylic
acid)
(PAA)
quaternized
chitosan
(QCS)
as
backbone
materials
loaded
TA-Gd/Fe-bimetallic-phenolic
coordination
polymer
was
prepared.
AQTGF
displayed
favorable
mechanical
properties,
self-healing
capabilities,
adhesion
characteristics,
response
performance.
vitro
experiments
demonstrated
that
exhibits
excellent
antimicrobial
capacity
angiogenic,
M2
macrophage
phenotype
polarizing
addition,
rat
tail
amputation
liver
hemostasis
had
Moreover,
vivo
studies
have
indicated
can
facilitate
accelerating
epidermal
growth,
promoting
collagen
deposition,
modulating
polarization,
inhibiting
inflammation,
angiogenesis.
conclusion,
study
provides
adaptable
holds
promise
treatment
chronic
wounds.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 20, 2025
Abstract
Bacterial
infections
can
lead
to
severe
medical
complications,
including
major
incidents
and
even
death,
posing
a
significant
challenge
in
clinical
trauma
repair.
Consequently,
the
development
of
new,
efficient,
non‐resistant
antimicrobial
agents
has
become
priority
for
practitioners.
In
this
study,
stepwise
hydrothermal
reaction
strategy
is
utilized
prepare
Fe
3
O
4
@MoS
2
core–shell
nanoparticles
(NPs)
with
photosynthesis‐like
activity
treatment
bacterial
infections.
The
NPs
continuously
catalyze
production
reactive
oxygen
species
(ROS)
from
hydrogen
peroxide
through
reactions
convert
light
energy
into
heat
photothermal
efficiency
30.30%.
addition,
photosynthetically
generated
ROS,
combined
iron‐induced
cell
death
mechanism
NPs,
confer
them
exceptional
broad‐spectrum
antibacterial
properties,
achieving
activities
up
98.62%
Staphylococcus
aureus
,
99.22%
Escherichia
coli
98.55%
methicillin‐resistant
.
composite
exhibits
good
safety
hemocompatibility.
Finally,
full‐thickness
diabetic
wound
model
validates
pro‐healing
properties
chronic
wounds.
Overall,
design
photosynthesis‐inspired
presents
new
perspectives
developing
efficient
nano‐enzymatic
compounds,
offering
promising
solution
challenges
drug
resistance
antibiotic
misuse.
