Biomimetic functionalized metal organic frameworks as multifunctional agents: Paving the way for cancer vaccine advances
Materials Today Bio,
Год журнала:
2024,
Номер
27, С. 101134 - 101134
Опубликована: Июнь 20, 2024
Biomimetic
functionalized
metal-organic
frameworks
(Fn-MOFs)
represent
a
cutting-edge
approach
in
the
realm
of
cancer
vaccines.
These
multifunctional
agents,
inspired
by
biological
systems,
offer
unprecedented
opportunities
for
development
next-generation
The
vast
surface
area,
tunable
pore
size,
and
diverse
chemistry
MOFs
provide
versatile
scaffold
encapsulation
protection
antigenic
components,
crucial
vaccine
stability
delivery.
This
work
delves
into
innovative
design
application
Fn-MOFs,
highlighting
their
role
as
carriers
immune
enhancement
potential
to
revolutionize
By
mimicking
natural
processes,
with
ability
be
myriad
chemical
entities,
exhibit
superior
biocompatibility
stimuli-responsive
behavior
facilitate
targeted
delivery
tumor
sites.
review
encapsulates
latest
advancements
Fn-MOF
technology,
from
synthesis
modification
integration
combination
therapies.
It
underscores
significance
biomimetic
approaches
overcoming
current
challenges
development,
such
antigen
evasion.
leveraging
nature
this
paves
way
strategies
vaccines,
aiming
induce
potent
long-lasting
responses
against
malignancies.
Язык: Английский
Copper-Consuming Nanoplatform for Alleviating Hypoxia and Overcoming Resistance to Sonodynamic Therapy of Breast Cancer
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(43), С. 58357 - 58369
Опубликована: Окт. 16, 2024
Sonodynamic
therapy
(SDT)
is
a
promising
treatment
modality
for
breast
cancer;
however,
its
effectiveness
often
impeded
by
the
hypoxic
tumor
microenvironment
owing
to
an
insufficient
oxygen
supply
in
solid
tumors.
To
overcome
this
challenge,
we
elaborately
developed
4T1
tumor-targeted
multifunctional
nanoagent
integrating
both
dendrimer-structured
copper
chelating
agents
and
organic
sonosensitizers
(IR820)
into
biotin-modified
nanoliposome
via
microfluidic-assisted
self-assembly.
In
particular,
aforementioned
agent
was
constructed
introducing
multiple
xanthate
groups
dendrimer
polymer,
which
showed
significant
selectivity
consumption
of
intracellular
levels.
Based
on
this,
nanoliposome-based
therapeutic
not
only
disrupted
activity
mitochondrial
complex
IV
directly
inhibit
cell
proliferation
but
also
suppressed
resistance
SDT
inhibition
cellular
respiration.
Both
vitro
vivo
studies
confirmed
that
designed
nanoagents
exhibit
synergistic
effect
IR820-mediated
SDT.
Taken
together,
approach
establishes
proof-of-concept
construction
copper-ion-modulated
nanomedicine
significantly
enhance
efficiency
oxygen-dependent
cancer
treatments.
Язык: Английский
Direct hydroxylation of toluene catalyzed by MOF-199 modified with PG 8 using H2O2 as oxidant
Materials Research Bulletin,
Год журнала:
2024,
Номер
178, С. 112850 - 112850
Опубликована: Апрель 28, 2024
Язык: Английский
Metal‐organic frameworks‐based nanomedicines to promote cancer immunotherapy: Recent advances and future directions
MedComm – Biomaterials and Applications,
Год журнала:
2024,
Номер
3(4)
Опубликована: Окт. 19, 2024
Abstract
Cancer
immunotherapy
uses
the
body's
immune
system
to
fight
tumors
by
restoring
natural
antitumor
responses.
Metal‐organic
frameworks
(MOFs),
characterized
their
unique
crystalline
porous
structures
formed
from
metal
ions
linked
organic
ligands,
offer
a
promising
solution.
Recent
studies
have
unveiled
potential
of
MOFs
in
cancer
immunotherapy.
The
exceptional
porosity
and
surface
area,
coupled
with
extraordinary
thermal
chemical
stability,
bring
significant
advantages
for
efficient
drug
loading
delivery
immunotherapeutic
agents.
adaptability
further
enhances
controlled
release
drugs
within
target
cells
increases
tumor
sensitivity
other
therapies
such
as
photodynamic,
photothermal,
radiotherapy.
This
multifunctional
carrier
contributes
modulating
microenvironment
reactivating
immunity,
providing
comprehensive
strategy
treatment.
In
this
review,
we
summarize
applications
checkpoint
blockade,
immunomodulator
delivery,
vaccine
discuss
existing
challenges
use
discussion
aims
insights
developing
better
treatments
enhancing
efficacy
Язык: Английский
FeS2@COF based nanocarrier for photothermal-enhanced chemodynamic/thermodynamic tumor therapy and immunotherapy via reprograming tumor-associated macrophages
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 15, 2024
Developing
high-performance
nanomedicines
to
enhance
antitumor
efficacy
remains
a
hot
point
in
the
field
of
biomedicine.
In
this
study,
we
designed
versatile
nanocomposite
(FeS₂@COF-HA/AIPH)
integrating
covalent
organic
frameworks
(COF)
functionalized
with
pyrite
(FeS₂)
for
synergistic
photothermal
(PTT),
chemodynamic
(CDT),
thermodynamic
(TDT)
therapies,
and
immunotherapy.
The
superior
effects
catalytic
capabilities
FeS₂@COF
enabled
minimally
invasive
PTT/CDT
combination.
nanoplatform,
its
mesoporous
structure,
also
served
as
drug
delivery
system,
encapsulating
thermos-decomposable
initiator
AIPH.
hyaluronic
acid
(HA)
coating
not
only
improved
tumor-targeting
efficiency
but
prevented
nonspecific
AIPH
release.
Under
near-infrared
(NIR)
irradiation,
localized
hyperthermia
triggered
decomposition,
generating
toxic
alkyl
radicals
(•R)
TDT,
further
enhancing
CDT
efficiency.
combination
PTT,
CDT,
immunotherapy
led
potent
minimal
systemic
toxicity,
both
vitro
vivo.
Notably,
nanoplatform
effectively
reprogrammed
tumor-associated
macrophages
(TAMs)
from
an
M2
M1
phenotype,
boosting
immunity.
This
multifunctional
platform
thus
offers
promising
strategy
integrated
immune
activation
tumor
therapy.
Язык: Английский
Disrupting calcium homeostasis and glycometabolism in engineered lipid-based pharmaceuticals propel cancer immunogenic death
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Biomimetic nanosystems based on cell membranes (BNCMs) for cancer immunotherapy
MedComm – Biomaterials and Applications,
Год журнала:
2024,
Номер
3(4)
Опубликована: Дек. 1, 2024
Abstract
With
the
development
of
nanosystems,
they
are
gradually
utilized
to
ameliorate
diverse
cancer
therapies.
Specifically
for
immunotherapy,
most
nanosystems
elaborately
designed
initiate
self‐sustaining
“cancer
immunity
cycle
(CIC)”
elicit
immune
response.
However,
owing
highly
complex
circulatory
environment,
may
face
issues
like
nonspecific
nanoparticle
uptake
and
rapid
clearance,
leaving
enormous
room
advancement.
For
employing
biomimetic
design
in
based
on
cell
membranes
(BNCMs)
inherit
various
functional
molecules
from
source
cells,
permitting
precise
tumor
targeting,
enhancing
blood
circulation,
conferring
more
desired
functionality
a
robust
To
take
full
advantage
BNCMs,
understanding
their
functions
immunotherapy
is
essential.
In
this
review,
unique
properties
BNCMs
derived
cells
main
preparation
strategies
introduced.
Subsequently,
recent
advances
improving
discussed
aspects
roles
particular
stages
CIC,
working
mechanisms
outer
highlighted.
Finally,
along
with
analysis
existing
bottlenecks
clinical
translation,
some
suggestions
future
put
forward.
Язык: Английский