Biomedical Materials,
Год журнала:
2024,
Номер
20(1), С. 015027 - 015027
Опубликована: Дек. 13, 2024
Abstract
Carbon
quantum
dots
(CQDs)
have
been
developed
into
a
popular
nanomaterial
due
to
their
abundant
surface
state,
good
biocompatibility,
and
excellent
antimicrobial
properties.
However,
CQDs
with
multiple
functions,
such
as
being
red-emitting,
having
antibacterial
activity,
pH
sensitivity,
rarely
reported.
In
this
work,
red-emitting
(R-CQDs)
optical
properties
activity
were
prepared
by
simple
green
hydrothermal
method.
applications,
the
R-CQDs
featured
generation
of
reactive
oxygen
species,
indicating
photodynamic
ability.
addition,
showed
fine
giving
them
potential
sensors
monitor
wounds
in
real
time.
The
promising
application
for
cell
imaging
was
also
demonstrated.
summary,
we
offer
sensitivity
monitoring
wounds,
shedding
light
on
biomedical
field.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Abstract
In
the
treatment
of
infectious
keratitis,
therapeutic
strategies
often
prioritize
enhancing
bactericidal
efficacy.
However,
endotoxins
released
from
Gram‐negative
bacteria
cause
inflammatory
reaction,
leading
to
corneal
structural
damage
and
scar
formation.
Given
that
polymyxin
B
(PMB)
can
bind
neutralize
lipopolysaccharide
(LPS),
this
study
employs
large‐pore
mesoporous
silica
nanoparticles
(lMSNs)
grafted
with
PMB
as
carriers
for
cationic
antibacterial
carbon
quantum
dots
(CQDs)
prepare
CQD@lMSN‐PMB,
which
enables
synchronous
sterilization
endotoxin
neutralization.
acidic
microenvironment,
accelerated
release
CQDs
eliminates
99.88%
within
2
h,
effectively
substituting
immune
mediated
sterilization.
Notably,
CQD@lMSN‐PMB
exhibits
exceptional
LPS
neutralization
performance
(2.22
µg
LPS/mg
CQD@lMSN‐PMB)
due
its
high
specific
surface
area.
an
keratitis
model,
inflammation
subsides
significantly
first
day
intervention
is
completely
resolved
by
3.
By
2,
interleukin‐1β,
interleukin‐6
tumor
necrosis
factor‐α
in
group
decrease
86.99%,
91.15%,
77.56%,
respectively,
compared
CQDs‐only
group.
Ultimately,
integrity
transparency
are
preserved,
suppressed
expressions
fibrosis‐related
factors
including
matrix
metalloproteinase
9,
transforming
growth
factor‐β
α‐smooth
muscle
actin.
Therefore,
strategy
outperforms
monotherapy
focused
solely
on
or
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 23, 2024
Abstract
Carbon
dots
(CDs)
with
intrinsic
bioactivities
are
candidates
for
bioimaging
and
disease
therapy
due
to
their
diverse
bioactivities,
high
biocompatibility,
multiple
functionalities
in
multimodal
theranostics.
It
is
a
multidisciplinary
research
hotspot
that
includes
biology,
physics,
materials
science,
chemistry.
This
progress
report
discusses
the
CDs
applications
The
relationship
between
synthesis
structure
of
summarized
analyzed
from
material
chemical
perspective.
including
anti‐tumor,
antibacterial,
anti‐inflammatory
etc.
discussed
biological
points
view.
Subsequently,
optical
electronic
properties
can
be
applied
biomedical
field
physical
Based
on
functional
review
CDs,
reviewed,
diagnosis
treatment,
activity,
Unlike
previous
reviews,
this
combines
disciplines
gain
more
comprehensive
understanding
mechanisms,
functions,
bioactivities.
Abstract
Bacterial
infections
continue
to
threaten
public
health
due
limitations
in
rapid
and
accurate
diagnostic
techniques.
While
broad‐spectrum
antibiotics
offer
empirical
treatment,
their
overuse
has
fuelled
the
emergence
of
antimicrobial
resistance
(AMR)
pathogens,
posing
a
critical
global
challenge.
In
this
scenario,
nanomaterial‐based
antibacterial
agents
emerge
as
promising
solution
combat
bacteria
inhibit
proliferation.
However,
selective
elimination
pathogenic
is
paramount.
This
review
highlights
recent
advancements
developing
nanomaterials
for
activity.
We
categorize
these
based
on
mode
action,
exploring
how
they
selectively
interact
with
potential
mechanisms.
offers
crucial
insights
researchers
nanotechnology
address
growing
threat
AMR.
Biomedical Materials,
Год журнала:
2024,
Номер
20(1), С. 015027 - 015027
Опубликована: Дек. 13, 2024
Abstract
Carbon
quantum
dots
(CQDs)
have
been
developed
into
a
popular
nanomaterial
due
to
their
abundant
surface
state,
good
biocompatibility,
and
excellent
antimicrobial
properties.
However,
CQDs
with
multiple
functions,
such
as
being
red-emitting,
having
antibacterial
activity,
pH
sensitivity,
rarely
reported.
In
this
work,
red-emitting
(R-CQDs)
optical
properties
activity
were
prepared
by
simple
green
hydrothermal
method.
applications,
the
R-CQDs
featured
generation
of
reactive
oxygen
species,
indicating
photodynamic
ability.
addition,
showed
fine
giving
them
potential
sensors
monitor
wounds
in
real
time.
The
promising
application
for
cell
imaging
was
also
demonstrated.
summary,
we
offer
sensitivity
monitoring
wounds,
shedding
light
on
biomedical
field.
