Applied Surface Science, Год журнала: 2024, Номер unknown, С. 162080 - 162080
Опубликована: Дек. 1, 2024
Язык: Английский
Chemical Engineering Journal, Год журнала: 2024, Номер 500, С. 157299 - 157299
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
8
Polymers, Год журнала: 2024, Номер 16(19), С. 2818 - 2818
Опубликована: Окт. 5, 2024
Hydrogels have emerged as promising candidates for biomedical applications, especially in the treatment of skin wounds, a result their unique structural properties, highly tunable physicochemical and excellent biocompatibility. The integration smart-response features into hydrogels allows dynamic responses to different external or internal stimuli. Therefore, this paper reviews design smart-responsive microenvironments field wound therapy. First, three typical chronic difficult-to-heal wounds key mechanisms affecting healing therapeutic measures are outlined. Strategies construction stimulus-responsive (e.g., pH, ROS, enzymes, glucose) temperature, light, electricity, magnetic fields) highlighted from perspective microenvironment vitro environment, constitutive relationships between material design, intelligent response, revealed. Finally, discusses severe challenges faced by during repair provides an outlook on combination artificial intelligence give scientific direction creating using hydrogel dressings that respond stimuli clinic.
Язык: Английский
Процитировано
6
Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 18
Опубликована: Фев. 18, 2025
Diabetic wounds are difficult to treat clinically because they heal poorly, often leading severe complications such as infections and amputations. Hydrogels with smart self-healing properties show great promise for treating diabetic wounds. These hydrogels capable of continuously dynamically responding changes in the wound environment, feature improved mechanical qualities capacity self-heal damage. We explore latest developments healing this review. First, we systematically summarize obstacles then highlighted significance hydrogels, explaining their stimulus-responsive mechanisms design approaches, along applications addressing these challenges. Finally, discussed unresolved potential avenues future research. anticipate that review will facilitate continued refinement dressings, aiming broader clinical adoption.
Язык: Английский
Процитировано
0
Macromolecular Bioscience, Год журнала: 2025, Номер unknown
Опубликована: Март 19, 2025
Abstract Innovative in situ drug‐releasing hydrogels are emerging as a promising therapeutic strategy for anterior segment ocular diseases, leveraging the unique anatomy of eye. Rapamycin (RAP) is an effective immunosuppressive agent organ transplantation; however, high hydrophobicity and low bioavailability have strongly constrained its clinical application. Chitosan (CS) used backbone, RAP can be loaded through supramolecular host‐guest interactions cyclodextrin (CD) to obtain chitosan‐conjugated‐(cydodextrin with 3,4‐dihydroxyhrocinnamic acid) rapamycin (CCH/RAP) controlled drug release properties. Here, hydrogel prepared by simple amidation reaction reported. It discovered that conjugated polymers form crosslinked networks non‐covalent bonds. The design allows excellent transparency suitable pore size, which ensure it applications. Moreover, results show introduction CD effectively delays initial RAP. This pioneering work presents eco‐friendly method fabricating superior delivery capabilities, hold significant potential mitigating immune rejection following corneal transplantation.
Язык: Английский
Процитировано
0
Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113716 - 113716
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Фев. 3, 2025
Intra-articular drug injections are effective for osteoarthritis (OA), but challenges such as the complex microenvironment and rapid diffusion require frequent injections. Herein, we propose a biofunctional hydrogel-based strategy prolonged delivery remodeling. We to functionalize zeolitic imidazolate framework-8 with tannic acid (TA-ZIF), anchor PTH-related peptide-1 (PTHrP-1) within this framework (TA-ZIF@P1) incorporate phenylboronic acid-modified gelatin-based hydrogel (GP hydrogel) system (GP@TA-ZIF@P1, GPTP responsive release properties that respond pathological microenvironments of OA. The facilitated controlled, sustained PTHrP-1 via dynamic boronic esters, in vitro vivo studies showing continuous over 28 days. It not only promotes chondrocyte proliferation also exhibits significant cytoprotective effects under hyperactive ROS IL-1β-induced conditions. Notably, transcriptome sequencing confirms facilitates both chondrogenesis inflammatory conditions by deactivating Wnt/β-Catenin signaling pathways enhancing PI3K/AKT pathway. Additionally, delays catabolic metabolism cartilage explants from mice environments. In surgical model mouse OA, show intra-articular injection hydrogels reduced periarticular bone remodeling promoted production glycosaminoglycans while offering chondroprotection against degeneration. To sum up, pioneering research on treatment combined system, offers valuable insights paradigm controlled PTHrP-1, representing advancement OA strategies.
Язык: Английский
Процитировано
0
Small Methods, Год журнала: 2025, Номер unknown
Опубликована: Апрель 3, 2025
Abstract Wound healing is a dynamic process often accompanied by bacterial infection. Bacterial proliferation and induced excessive inflammation hinder the in infectious wounds, leading to refractory wounds. Addressing challenges of wounds requires development multifunctional dressings capable eliminating infection, relieving inflammation, restoring wound microenvironment. In this study, Ag + ‐ion functionalized Cu 2+ UiO‐67 metal‐organic framework (MOF‐Ag MOF‐Cu) are incorporated into an oxidized dextran gelatin mixture fabricate hydrogel, termed as OGAC. The resulting OGAC exhibited injectable, adhesive, hemostatic, antibacterial, anti‐inflammatory properties, along with good biocompatibility. hydrogel precursor could be injected situ at site cover wound, serving physical barrier protect Moreover, demonstrates efficient antibacterial anti‐biofilm activity, against both Escherichia coli Staphylococcus aureus . Additionally, has superoxide dismutase‐like glutathione peroxidase‐like activity for anti‐oxidation, which conducive reduce wound. reveals high performance infected mouse model. These findings suggest that promising candidate multiple functionalities clinical management.
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Дек. 20, 2024
Periodontitis is a chronic inflammatory disease caused by dental plaque, which leads to tooth loosening and shifting or even loss. Current treatments, including mechanical debridement antibiotics, often fail eradicate recalcitrant biofilms mitigate excessive inflammation. Moreover, these interventions can disrupt the oral microbiome, potentially compromising long-term treatment outcomes. To address limitations, an injectable nanoenzyme hydrogel composed of dopamine (DA)-modified hyaluronic acid (HA) scaffold graphdiyne-iron (GDY-Fe) complex, named GDY-Fe@HA-DA, exhibits excellent tissue adhesion, self-healing, antibacterial properties, biocompatibility. Under near-infrared laser irradiation, GDY-Fe@HA-DA effectively eradicates variety pathogens, Escherichia coli, Staphylococcus aureus, Porphyromonas gingivalis, through synergistic combination chemodynamical photothermal therapies. The hydrogel's efficacy further validated in both bacterial-infected skin wounds rat periodontitis models. It alleviates environment promotes wound healing periodontal recovery. This findings highlight potential as promising therapeutic material for other injuries.
Язык: Английский
Процитировано
3
Applied Surface Science, Год журнала: 2024, Номер unknown, С. 162080 - 162080
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
1