ACS Nano,
Год журнала:
2020,
Номер
14(4), С. 5121 - 5134
Опубликована: Апрель 13, 2020
Supramolecular
nanomaterials
as
drug
carriers
have
recently
received
increasing
attention
due
to
their
intrinsic
merits
such
high
stability,
strong
inclusion
capability,
and
facile
modification
of
the
parental
structure;
however,
intelligent
ones
with
combined
capacities
long
blood
circulation,
highly
efficient
tumor
cell
uptake,
site-oriented
release
inside
cells
are
still
rather
limited.
Herein,
we
report
a
strategy
using
supramolecular
aggregation-induced
emission
(AIE)
nanodots
for
image-guided
delivery,
which
integrate
both
advantages
AIE
nanomaterials.
The
dots
prepared
by
host-guest
coassembly
matrix
metalloproteinase-2
(MMP-2)
sensitive
PEG-peptide
(PEG2000-RRRRRRRR
(R8)-PLGLAG-EKEKEKEKEKEK
(EK6))
functional
α-cyclodextrins
(α-CD)
derivatives
that
conjugated
anticancer
gemcitabine
(GEM)
far-red/near-infrared
fluorescent
rhodanine-3-acetic
acid-based
luminogen,
respectively.
realize
circulation
time
virtue
zwitterionic
stealth
peptide
EK6.
After
largely
accumulating
in
tissues
enhanced
permeability
retention
effect,
can
successively
respond
tumor-overexpressed
MMP-2
intracellular
reductive
microenvironment,
achieving
cancer
cellular
uptake
selective
GEM
within
cells,
thus
exhibit
excellent
inhibition
ability
subcutaneous
orthotopic
pancreatic
models.
Materials Horizons,
Год журнала:
2018,
Номер
6(3), С. 428 - 433
Опубликована: Ноя. 15, 2018
In-depth
discussion
on
recent
progress
of
fundamental
understanding
AIE
mechanisms,
identifying
the
existing
challenges
and
opportunities
for
future
developments.
Advanced Materials,
Год журнала:
2019,
Номер
31(52)
Опубликована: Ноя. 7, 2019
Immunogenic
cell
death
(ICD)
provides
momentous
theoretical
principle
for
modern
cancer
immunotherapy.
However,
the
currently
available
ICD
inducers
are
still
very
limited
and
photosensitizer-based
ones
can
hardly
induce
sufficient
to
achieve
satisfactory
immunotherapy
by
themselves.
Herein,
an
organic
photosensitizer
(named
TPE-DPA-TCyP)
with
a
twisted
molecular
structure,
strong
aggregation-induced
emission
activity,
specific
ability
is
reported
effectively
inducing
focused
mitochondrial
oxidative
stress
of
cells,
which
serve
as
much
superior
inducer
popularly
used
ones,
including
chlorin
e6
(Ce6),
pheophorbide
A,
oxaliplatin.
Furthermore,
more
effective
in
vivo
immunogenicity
TPE-DPA-TCyP
than
Ce6
also
demonstrated
using
prophylactic
tumor
vaccination
model.
The
underlying
mechanism
effectiveness
robustness
antitumor
immunity
immune-memory
effect
verified
immune
analyses.
This
study
thus
reveals
that
highly
strategy
evoke
abundant
large-scale
ICD.
Angewandte Chemie International Edition,
Год журнала:
2020,
Номер
60(14), С. 7476 - 7487
Опубликована: Июнь 9, 2020
Fluorescence
imaging
in
the
second
near-infrared
(NIR-II)
window
facilitated
by
aggregation-induced
emission
luminogens
(AIEgens)
is
an
emerging
research
field.
NIR-II
AIEgens
overcome
limitations
imposed
penetration
depth
and
fluorescence
efficiency,
offering
high-performance
with
enhanced
precision.
Some
reported
demonstrate
capabilities
for
photoacoustic
bimodal
imaging,
guided
photothermal
therapy,
which
not
only
improves
diagnosis
accuracy
but
provides
efficient
theranostic
platform
to
accelerate
preclinical
translation
as
well.
This
minireview
summarizes
recent
efforts
on
exploiting
regard
molecular
design
strategies
bioapplications,
puts
forward
current
challenges
promising
prospects.
timely
sketch
should
benefit
further
exploitation
of
diverse
multifunctional
a
wide
array
applications.
Advanced Materials,
Год журнала:
2019,
Номер
32(3)
Опубликована: Март 29, 2019
Abstract
On
the
basis
of
Jablonski
diagram,
photophysical
properties
optical
agents
are
highly
associated
with
biomedical
function
and
efficacy.
Herein,
focus
is
on
organic/polymer
recent
progress
in
main
strategies
for
regulating
their
to
achieve
superior
cancer
diagnosis/phototheranostics
applications
highlighted.
Both
approaches
nanoengineering
molecular
design,
which
can
lead
optimized
effectiveness
required
function,
discussed.
ACS Applied Bio Materials,
Год журнала:
2018,
Номер
1(6), С. 1768 - 1786
Опубликована: Окт. 30, 2018
The
emergence
of
the
aggregation-induced
emission
(AIE)
concept
significantly
changes
cognition
scientific
community
toward
classic
photophysical
phenomena.
More
importantly,
AIE
phenomenon
has
brought
huge
opportunities
for
analysis
bioactive
species,
monitoring
complicated
biological
processes,
and
elucidation
key
physiological
pathological
behaviors.
As
a
class
promising
luminescent
materials,
luminogens
(AIEgens)
are
weakly
or
non-emissive
in
form
isolated
molecular
species
but
emit
particularly
strong
fluorescence
aggregated
solid
states.
Motivated
by
prominent
advantages
such
as
high
brightness,
large
Stokes
shift,
excellent
photostability,
good
biocompatibility,
AIEgen-based
bioprobes
have
been
widely
explored
field
biomedicine.
This
review
aims
to
provide
systematic
summary
developmental
history
an
in-depth
perspective
current
landscape
biomedical
field,
with
emphasis
on
discussions
major
working
principles.
milestones
historical
development
first
reviewed.
A
total
four
research
directions
then
extracted,
including
biomacromolecule
sensing
(at
level),
vitro
cell
imaging
cellular
vivo
animal
cancer
theranostics
levels),
together
clear-cut
tables
showing
comprehensive
cases
further
study.
Lastly,
this
is
concluded
several
perspectives
future
directions.
It
believed
that
will
play
vital
roles
exploration
mysterious
life
processes
integration
various
cutting-edge
modalities
techniques
ultimate
goal
addressing
more
healthcare
issues.
Angewandte Chemie International Edition,
Год журнала:
2020,
Номер
59(25), С. 10008 - 10012
Опубликована: Янв. 25, 2020
Abstract
Host–guest
complexation
between
calix[5]arene
and
aggregation‐induced
emission
luminogen
(AIEgen)
can
significantly
turn
off
both
the
energy
dissipation
pathways
of
intersystem
crossing
thermal
deactivation,
enabling
absorbed
excitation
to
mostly
focus
on
fluorescence
emission.
The
co‐assembly
amphiphiles
AIEgens
affords
highly
emissive
supramolecular
AIE
nanodots
thanks
their
interaction
severely
restricting
intramolecular
motion
AIEgens,
which
also
show
negligible
generation
cytotoxic
reactive
oxygen
species.
In
vivo
studies
with
a
peritoneal
carcinomatosis‐bearing
mouse
model
indicate
that
such
dots
have
rather
low
in
side
toxicity
serve
as
superior
fluorescent
bioprobe
for
ultrasensitive
image‐guided
cancer
surgery.
Aggregate,
Год журнала:
2021,
Номер
2(1), С. 95 - 113
Опубликована: Янв. 22, 2021
Abstract
Phototheranostics
that
concurrently
and
complementarily
integrate
real‐time
diagnosis
in
situ
therapeutic
capabilities
one
platform
has
become
the
advancing
edge
of
precision
medicine.
Organic
agents
possess
merits
facile
preparation,
high
purity,
tunable
photophysical
property,
good
biocompatibility,
potential
biodegradability,
which
have
shown
great
promise
for
disease
theranostics.
This
review
summarizes
recent
achievements
organic
phototheranostic
applications,
especially
rationally
utilize
energy
dissipation
pathways
Jablonski
diagram
to
modulate
fluorescence
emission,
photoacoustic/photothermal
production,
photodynamic
processes.
Of
particular
interest
are
systems
exhibiting
huge
differences
aggregate
state
as
compared
with
solution
or
single
molecule
form,
during
intramolecular
motions
play
an
important
role
regulating
properties.
The
advances
from
such
aspect
biomedical
applications
including
high‐resolution
imaging,
activatable
imaging
therapy,
adaptive
theranostics,
image‐guided
surgery,
immunotherapy,
afterglow
discussed.
A
brief
summary
perspective
this
field
also
presented.
We
hope
will
be
helpful
researchers
interested
bioprobe
design
theranostic
inspire
new
insights
into
linkage
between
science
field.
