Chemical Society Reviews,
Год журнала:
2020,
Номер
49(4), С. 1253 - 1321
Опубликована: Янв. 1, 2020
Bismuth-containing
nanomaterials
offer
a
new
opportunity
to
move
beyond
current
achievements
in
the
fields
of
drug
delivery,
diagnosis,
cancer
therapy,
biosensing,
and
tissue
engineering.
This
review
describes
emerging
applications
perspective
these
nanoparticles.
Cancers,
Год журнала:
2020,
Номер
12(8), С. 2130 - 2130
Опубликована: Июль 31, 2020
Osteosarcoma
(OS)
is
the
most
frequent
primary
bone
cancer
in
children
and
adolescents
third
adults.
Many
inherited
germline
mutations
are
responsible
for
syndromes
that
predispose
to
osteosarcomas
including
Li
Fraumeni
syndrome,
retinoblastoma
Werner
Bloom
syndrome
or
Diamond–Blackfan
anemia.
TP53
frequently
altered
gene
osteosarcoma.
Among
other
genes
mutated
more
than
10%
of
OS
cases,
c-Myc
plays
a
role
development
promotes
cell
invasion
by
activating
MEK–ERK
pathways.
Several
genomic
studies
showed
alterations
RB
pediatric
patients.
driver
have
been
reported
NOTCH1,
FOS,
NF2,
WIF1,
BRCA2,
APC,
PTCH1
PRKAR1A
genes.
Some
miRNAs
such
as
miR-21,
-34a,
-143,
-148a,
-195a,
-199a-3p
-382
regulate
pathogenic
activity
MAPK
PI3K/Akt-signaling
pathways
CD133+
osteosarcoma
cells
shown
exhibit
stem-like
expression
can
be
tumor-initiating
play
metastasis
drug
resistance.
Although
currently
treatment
based
on
adriamycin
chemoregimens
surgery,
there
several
potential
targeted
therapies
development.
First
all,
safety
cabozantinib
were
studied,
well
sorafenib
pazopanib.
Finally,
novel
bifunctional
molecules,
imaging
targeting
applications
may
used
future.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Март 15, 2023
Exosome
is
a
subgroup
of
extracellular
vesicles,
which
has
been
serving
as
an
efficient
therapeutic
tool
for
various
diseases.
Engineered
exosomes
are
the
sort
modified
with
surface
decoration
and
internal
molecules.
After
appropriate
modification,
engineered
able
to
deliver
antitumor
drugs
tumor
sites
efficiently
precisely
fewer
treatment-related
adverse
effects.
However,
there
still
exist
many
challenges
clinical
translation
exosomes.
For
instance,
what
sources
modification
strategies
could
endow
most
activity
poorly
understood.
Additionally,
how
choose
appropriately
in
different
therapies
another
unresolved
problem.
In
this
review,
we
summarized
characteristics
exosomes,
especially
spatial
temporal
properties.
concluded
recent
advances
cancer
fields,
including
sources,
isolation
technologies,
strategies,
labeling
imaging
methods
Furthermore,
applications
were
summarized,
such
photodynamic
therapy,
gene
immunotherapy.
Consequently,
above
provides
researchers
community
latest
ideas
on
exosome
new
direction
drug
development,
prospective
accelerate
cancer-targeted
therapy.
Advanced Materials,
Год журнала:
2020,
Номер
33(2)
Опубликована: Ноя. 30, 2020
Abstract
Infectious
or
immune
diseases
have
caused
serious
threat
to
human
health
due
their
complexity
and
specificity,
emerging
drug
delivery
systems
(DDSs)
evolved
into
the
most
promising
therapeutic
strategy
for
drug‐targeted
therapy.
Various
mesoporous
biomaterials
are
exploited
applied
as
efficient
nanocarriers
loading
drugs
by
virtue
of
large
surface
area,
high
porosity,
prominent
biocompatibility.
Nanosized
show
great
potential
in
biomedical
research,
it
has
become
research
hotspot
interdisciplinary
field.
Herein,
recent
progress
assembly
mechanisms
on
inorganic
(e.g.,
silica,
carbon,
metal
oxide)
summarized
systematically,
typical
functionalization
methods
(i.e.,
hybridization,
polymerization,
doping)
also
discussed
depth.
Particularly,
structure–activity
relationship
effect
physicochemical
parameters
biomaterials,
including
morphologies
hollow,
core–shell),
pore
textures
size,
volume),
features
roughness
hydrophilic/hydrophobic)
DDS
application
overviewed
elucidated
detail.
As
one
important
development
directions,
advanced
stimuli‐responsive
DDSs
pH,
temperature,
redox,
ultrasound,
light,
magnetic
field)
highlighted.
Finally,
prospect
disease
therapeutics
is
stated,
will
open
a
new
spring
nanocarriers.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Ноя. 24, 2023
Abstract
Mesoporous
silica
nanoparticles
(MSNs)
are
recognized
as
a
prime
example
of
nanotechnology
applied
in
the
biomedical
field,
due
to
their
easily
tunable
structure
and
composition,
diverse
surface
functionalization
properties,
excellent
biocompatibility.
Over
past
two
decades,
researchers
have
developed
wide
variety
MSNs-based
nanoplatforms
through
careful
design
controlled
preparation
techniques,
demonstrating
adaptability
various
application
scenarios.
With
continuous
breakthroughs
MSNs
fields
biosensing,
disease
diagnosis
treatment,
tissue
engineering,
etc.,
gradually
moving
from
basic
research
clinical
trials.
In
this
review,
we
provide
detailed
summary
beginning
with
comprehensive
overview
development
history.
We
then
discuss
types
nanostructured
architectures,
well
classification
nanocomposites
according
elements
existed
inorganic
functional
components.
Subsequently,
summarize
primary
purposes
surface-functionalized
modifications
MSNs.
following,
applications
MSNs,
highlight
targeted
therapeutic
modalities
currently
developed.
Given
importance
translation,
also
progress
Finally,
take
perspective
on
future
direction
remaining
challenges
field.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Авг. 12, 2024
Cancer
remains
a
significant
risk
to
human
health.
Nanomedicine
is
new
multidisciplinary
field
that
garnering
lot
of
interest
and
investigation.
shows
great
potential
for
cancer
diagnosis
treatment.
Specifically
engineered
nanoparticles
can
be
employed
as
contrast
agents
in
diagnostics
enable
high
sensitivity
high-resolution
tumor
detection
by
imaging
examinations.
Novel
approaches
labeling
are
also
made
possible
the
use
nanoprobes
nanobiosensors.
The
achievement
targeted
medication
delivery
therapy
accomplished
through
rational
design
manufacture
nanodrug
carriers.
Nanoparticles
have
capability
effectively
transport
medications
or
gene
fragments
tissues
via
passive
active
targeting
processes,
thus
enhancing
treatment
outcomes
while
minimizing
harm
healthy
tissues.
Simultaneously,
context
radiation
sensitization
photothermal
enhance
therapeutic
efficacy
malignant
tumors.
This
review
presents
literature
overview
summary
how
nanotechnology
used
According
oncological
diseases
originating
from
different
systems
body
combining
pathophysiological
features
cancers
at
sites,
we
most
recent
developments
applications.
Finally,
briefly
discuss
prospects
challenges
cancer.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Март 22, 2023
Abstract
Osteosarcoma,
the
most
common
malignant
tumor
of
bone,
seriously
influences
people’s
lives
and
increases
their
economic
burden.
Conventional
chemotherapy
drugs
achieve
limited
therapeutic
effects
owing
to
poor
targeting
severe
systemic
toxicity.
Nanocarrier-based
drug
delivery
systems
can
significantly
enhance
utilization
efficiency
chemotherapeutic
through
ligand
modifications
reduce
occurrence
adverse
effects.
A
variety
ligand-modified
nano-drug
have
been
developed
for
different
schemes.
Here
we
review
biological
characteristics
main
challenges
current
therapy
OS,
further
elaborate
on
schemes
selection
osteosarcoma,
which
may
provide
new
horizons
development
advanced
targeted
in
future.
