Journal of Cancer,
Год журнала:
2019,
Номер
11(1), С. 69 - 82
Опубликована: Дек. 6, 2019
Osteosarcoma
is
the
most
common
primary
malignant
bone
tumor
mainly
occurred
in
children
and
adolescence,
chemotherapy
limited
for
side
effects
development
of
drug
resistance.Advances
nanotechnology
knowledge
cancer
biology
have
led
to
significant
improvements
developing
tumor-targeted
delivery
nanocarriers,
some
even
entered
clinically
application.Delivery
chemotherapeutic
agents
by
functionalized
smart
nanocarriers
could
protect
drugs
from
rapid
clearance,
prolong
circulating
time,
increase
concentration
at
sites,
thus
enhancing
therapeutic
efficacy
reducing
effects.Various
been
designed
tested
osteosarcoma
treatment,
but
them
are
still
experimental
stage,
more
further
studies
needed
before
clinical
application.In
this
present
review,
we
briefly
describe
types
commonly
used
discuss
strategies
osteosarcoma-targeted
controlled
release
drugs.The
application
nanoparticles
management
metastatic
also
discussed.The
purpose
article
an
overview
recent
progress
nanoscale
platforms
osteosarcoma,
inspire
new
ideas
develop
effective
options.
Pharmaceutics,
Год журнала:
2020,
Номер
12(1), С. 83 - 83
Опубликована: Янв. 20, 2020
Bone
diseases,
such
as
bone
cancer,
infection
and
osteoporosis,
constitute
a
major
issue
for
modern
societies
consequence
of
their
progressive
ageing.
Even
though
these
pathologies
can
be
currently
treated
in
the
clinic,
some
those
treatments
present
drawbacks
that
may
lead
to
severe
complications.
For
instance,
chemotherapy
lacks
great
tumor
tissue
selectivity,
affecting
healthy
diseased
tissues.
In
addition,
inappropriate
use
antimicrobials
is
leading
appearance
drug-resistant
bacteria
persistent
biofilms,
rendering
current
antibiotics
useless.
Furthermore,
antiosteoporotic
many
side
effects
poor
bioavailability
need
higher
doses.
view
existing
evidence,
encapsulation
selective
delivery
tissues
different
therapeutic
compounds
seem
highly
convenient.
this
sense,
silica-based
mesoporous
nanoparticles
offer
loading
capacity
within
pores,
possibility
modifying
surface
target
particles
malignant
areas
biocompatibility.
This
manuscript
intended
comprehensive
review
available
literature
on
complex
diseases
with
nanoparticles—the
further
development
which
eventual
translation
into
clinic
could
bring
significant
benefits
our
future
society.
Theranostics,
Год журнала:
2020,
Номер
10(25), С. 11837 - 11861
Опубликована: Янв. 1, 2020
Recently,
the
rapid
development
of
biomaterials
has
induced
great
interest
in
precisely
targeted
treatment
bone-related
diseases,
including
bone
cancers,
infections,
and
inflammation.
Realizing
noninvasive
therapeutic
effects,
as
well
improving
tissue
regeneration,
is
essential
for
success
bone‑related
disease
therapies.
In
recent
years,
researchers
have
focused
on
stimuli-responsive
strategies
to
treat
diseases
realize
regeneration.
Among
various
external
stimuli
therapy,
near
infrared
(NIR)
light
attracted
considerable
interests
due
its
high
penetration
capacity,
minimal
damage
toward
normal
tissues,
easy
remote
control
properties.
The
main
objective
this
systematic
review
was
reveal
current
applications
NIR
light-assisted
phototherapy
Database
collection
completed
by
June
1,
2020,
a
total
81
relevant
studies
were
finally
included.
We
outlined
photothermal,
photodynamic
photobiomodulation
effects
under
irradiation
based
retrieved
literatures.
addition,
advantages
promising
light-responsive
drug
delivery
systems
spatiotemporal-controlled
therapy
summarized.
These
findings
revealed
that
plays
an
important
role
with
significant
promise
further
biomedical
clinical
applications.
Biosensors,
Год журнала:
2021,
Номер
11(2), С. 55 - 55
Опубликована: Фев. 20, 2021
Osteosarcoma
(OSA)
is
a
type
of
bone
cancer
that
begins
in
the
cells
form
bones.
OSA
rare
mesenchymal
neoplasm
derived
from
stem
cells.
Genome
disorganization,
chromosomal
modifications,
deregulation
tumor
suppressor
genes,
and
DNA
repair
defects
are
factors
most
responsible
for
development.
Despite
significant
advances
diagnosing
treatment
OSA,
patients’
overall
survival
has
not
improved
within
last
twenty
years.
Lately,
modern
nanotechnology
have
spurred
development
management
offered
several
advantages
to
overcome
drawbacks
conventional
therapies.
This
technology
allowed
practical
design
nanoscale
devices
combined
with
numerous
functional
molecules,
including
tumor-specific
ligands,
antibodies,
anti-cancer
drugs,
imaging
probes.
Thanks
their
small
sizes,
desirable
drug
encapsulation
efficiency,
good
bioavailability,
functionalized
nanomaterials
found
wide-spread
applications
combating
progression.
review
invokes
possible
utility
engineered
diagnosis
treatment,
motivating
researchers
seek
new
strategies
tackling
challenges
associated
it.
Nanomaterials,
Год журнала:
2020,
Номер
10(11), С. 2186 - 2186
Опубликована: Ноя. 2, 2020
Nanomedicine
is
a
rapidly
growing
field
that
uses
nanomaterials
for
the
diagnosis,
treatment
and
prevention
of
various
diseases,
including
cancer.
Various
biocompatible
nanoplatforms
with
diversified
capabilities
tumor
targeting,
imaging,
therapy
have
materialized
to
yield
individualized
therapy.
However,
due
their
unique
properties
brought
about
by
small
size,
safety
concerns
emerged
as
physicochemical
can
lead
altered
pharmacokinetics,
potential
cross
biological
barriers.
In
addition,
intrinsic
toxicity
some
inorganic
materials
(i.e.,
heavy
metals)
ability
accumulate
persist
in
human
body
has
been
challenge
translation.
Successful
clinical
translation
these
nanoparticles
heavily
dependent
on
stability,
circulation
time,
access
bioavailability
disease
sites,
profile.
This
review
covers
preclinical
inorganic-nanoparticle
based
nanomaterial
utilized
cancer
imaging
therapeutics.
A
special
emphasis
put
rational
design
develop
non-toxic/safe
nanoparticle
constructs
increase
viability
translatable
nanomedicine
therapies.
Frontiers in Chemistry,
Год журнала:
2022,
Номер
10
Опубликована: Сен. 14, 2022
Nanoparticles
offer
numerous
advantages
in
various
fields
of
science,
particularly
medicine.
Over
recent
years,
the
use
nanoparticles
disease
diagnosis
and
treatments
has
increased
dramatically
by
development
stimuli-responsive
nano-systems,
which
can
respond
to
internal
or
external
stimuli.
In
last
10
many
preclinical
studies
were
performed
on
physically
triggered
nano-systems
develop
optimize
stable,
precise,
selective
therapeutic
diagnostic
agents.
this
regard,
systems
must
meet
requirements
efficacy,
toxicity,
pharmacokinetics,
safety
before
clinical
investigation.
Several
undesired
aspects
need
be
addressed
successfully
translate
these
physical
as
biomaterials,
into
practice.
These
have
commonly
taken
account
when
developing
systems;
thus,
also
applicable
for
based
nanomaterials.
This
review
focuses
(PTNSs),
with
theranostic
applications.
types
polymeric
micelles
hydrogels,
mesoporous
silica,
magnets
are
reviewed
discussed
aspects.
Pharmaceutics,
Год журнала:
2022,
Номер
14(4), С. 770 - 770
Опубликована: Март 31, 2022
Modern
biomedicine
aims
to
develop
integrated
solutions
that
use
medical,
biotechnological,
materials
science,
and
engineering
concepts
create
functional
alternatives
for
the
specific,
selective,
accurate
management
of
medical
conditions.
In
particular
case
tissue
engineering,
designing
a
model
simulates
all
qualities
fulfills
requirements
is
continuous
challenge
in
field
bone
regeneration.
The
therapeutic
protocols
used
healing
applications
are
limited
by
hierarchical
nature
extensive
vascularization
osseous
tissue,
especially
large
lesions.
this
regard,
nanotechnology
paves
way
new
era
treatment,
repair
regeneration,
enabling
fabrication
complex
nanostructures
similar
those
found
natural
which
exhibit
multifunctional
bioactivity.
This
review
lay
out
tremendous
outcomes
using
inorganic
nanoparticles
applications,
including
modern
strategies
bone-related
pathologies.
Advanced Materials,
Год журнала:
2023,
Номер
36(11)
Опубликована: Дек. 27, 2023
Abstract
Treatment
of
diabetic
wounds
is
a
significant
clinical
challenge
due
to
the
massive
infections
caused
by
bacteria.
In
this
study,
multifunctional
glycol
chitosan
and
polydopamine‐coated
BiO
1‐x
I
(GPBO)
nanoparticles
(NPs)
with
near‐infrared
(NIR)
photothermal
photocatalytic
abilities
are
prepared.
When
infection
occurs,
local
microenvironment
becomes
acidic,
pH‐switchable
GPBO
can
target
bacteria
wound
site.
The
NIR‐assisted
treatment
exhibits
anti‐bacterial
effects
fast
response,
high
efficiency,
long
duration
Escherichia
coli,
Pseudomonas
aeruginosa
,
Staphylococcus
aureus
.
achieves
excellent
imaging
CT
mouse
subcutaneous
abscess
model.
With
assistance
NIR
irradiation,
promotes
healing
model
anti‐bacteria,
anti‐inflammation,
M2
polarization
promotion
macrophages,
angiogenesis.
This
first‐time
report
nano‐sized
I.
synthesis
selected
application
for
targeted
therapy
presented.
study
offers
an
example
NP‐assisted
precise
diagnosis
bacterial
diseases.
