Advanced Functional Materials,
Год журнала:
2023,
Номер
33(21)
Опубликована: Фев. 22, 2023
Abstract
Infectious
diseases
(such
as
wound
infections)
caused
by
pathogenic
microorganisms
can
lead
to
serious
consequences
and
even
threaten
life.
The
emergence
of
drug‐resistant
bacteria
has
severely
prevented
the
validity
traditional
antibiotics.
Therefore,
developing
novel
antimicrobial
strategies
without
holds
great
promise
for
maximizing
efficacy
minimizing
risk
drug‐resistance
resistant
bacterial
infections.
Herein,
near‐infrared
(NIR)‐absorbing
A–D–A
type
conjugated
oligomers
with
a
tunable
backbone
are
designed
synthesized
regulating
their
photothermal
conversion.
After
being
assembled
into
nanoparticles,
oligomer
CP‐F8P
nanoparticles
(NPs)
containing
strong
electron‐donating
component
show
strongest
conversion
efficiency
81.6%.
low
concentration
NPs
receive
over
99%
against
Amp
r
E.
coli
,
S.
aureus
C.
albicans
upon
NIR
irradiation,
phototherapy
treatment
effectively
promote
healing
in
diabetic
mice
good
biocompatibility.
This
work
provides
ideas
design
efficient
NIR‐activated
reagents
microbial
Chemical Reviews,
Год журнала:
2023,
Номер
123(11), С. 6891 - 6952
Опубликована: Май 3, 2023
All
forms
of
energy
follow
the
law
conservation
energy,
by
which
they
can
be
neither
created
nor
destroyed.
Light-to-heat
conversion
as
a
traditional
yet
constantly
evolving
means
converting
light
into
thermal
has
been
enduring
appeal
to
researchers
and
public.
With
continuous
development
advanced
nanotechnologies,
variety
photothermal
nanomaterials
have
endowed
with
excellent
harvesting
capabilities
for
exploring
fascinating
prospective
applications.
Herein
we
review
latest
progresses
on
nanomaterials,
focus
their
underlying
mechanisms
powerful
light-to-heat
converters.
We
present
an
extensive
catalogue
nanostructured
materials,
including
metallic/semiconductor
structures,
carbon
organic
polymers,
two-dimensional
materials.
The
proper
material
selection
rational
structural
design
improving
performance
are
then
discussed.
also
provide
representative
overview
techniques
probing
photothermally
generated
heat
at
nanoscale.
finally
recent
significant
developments
applications
give
brief
outlook
current
challenges
future
directions
nanomaterials.
Advanced Functional Materials,
Год журнала:
2021,
Номер
31(25)
Опубликована: Март 31, 2021
Abstract
Photothermal
therapy
(PTT),
which
utilizes
near‐infrared
light‐absorbing
agents
to
ablate
tumor,
has
emerged
as
a
highly
promising
anticancer
strategy
and
received
intensive
clinical
trials
in
recent
years.
Mild‐temperature
PTT,
circumvents
the
limitations
of
conventional
PTT
(e.g.,
thermoresistance
adverse
effects),
is
emerging
shows
great
potential
forthcoming
applications.
However,
mild‐temperature
without
adjuvant
not
able
completely
eradicate
tumors
because
its
therapeutic
efficacy
dramatically
impaired
by
inferior
heat
intensity.
As
result,
strategies
capable
enhancing
are
urgently
necessitated,
mainly
rely
on
on‐demand
fabrication
functionalized
nanoagents.
In
this
review,
nanoagent‐promoted
highlighted.
Furthermore,
challenges
opportunities
field
rationally
proposed,
hopefully
people
can
be
encouraged
therapy.
Carbon
dots
(CDs),
comprising
crystalline
graphitized
carbon
cores
and
polymer
surface
groups,
are
currently
attracting
a
lot
of
interest
in
biological
fields
owing
to
their
fluorescent
properties,
high
photostability,
biocompatibility
low
toxicity.
In
addition,
the
easy
preparation
functionalization
CDs
stimulate
development
CDs‐based
composite
materials
with
specific
functions.
Presently,
applications
growing
at
remarkable
speed,
justifying
need
for
up‐to‐date
review
articles
that
capture
recent
progress
this
blossoming
field.
review,
breakthroughs
synthesis,
modification,
optical
toxicology
biocatalytic
platforms
described.
Further,
research
related
bioimaging,
biosensing,
drug
delivery,
antibacterial,
anticancer
(photothermal
therapy,
photodynamic
therapy
synergistic
therapy)
antiviral
therapies
involving
discussed
detail.
Finally,
perspective
on
prospects
challenges
biomedicine
biotechnology
is
provided.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(15), С. 6307 - 6416
Опубликована: Янв. 1, 2022
This
review
highlights
the
recent
advances
of
metalated
covalent
organic
frameworks,
including
synthetic
strategies
and
applications,
discusses
current
challenges
future
directions.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Ноя. 24, 2023
Abstract
Mesoporous
silica
nanoparticles
(MSNs)
are
recognized
as
a
prime
example
of
nanotechnology
applied
in
the
biomedical
field,
due
to
their
easily
tunable
structure
and
composition,
diverse
surface
functionalization
properties,
excellent
biocompatibility.
Over
past
two
decades,
researchers
have
developed
wide
variety
MSNs-based
nanoplatforms
through
careful
design
controlled
preparation
techniques,
demonstrating
adaptability
various
application
scenarios.
With
continuous
breakthroughs
MSNs
fields
biosensing,
disease
diagnosis
treatment,
tissue
engineering,
etc.,
gradually
moving
from
basic
research
clinical
trials.
In
this
review,
we
provide
detailed
summary
beginning
with
comprehensive
overview
development
history.
We
then
discuss
types
nanostructured
architectures,
well
classification
nanocomposites
according
elements
existed
inorganic
functional
components.
Subsequently,
summarize
primary
purposes
surface-functionalized
modifications
MSNs.
following,
applications
MSNs,
highlight
targeted
therapeutic
modalities
currently
developed.
Given
importance
translation,
also
progress
Finally,
take
perspective
on
future
direction
remaining
challenges
field.
Medicinal Research Reviews,
Год журнала:
2023,
Номер
43(6), С. 2115 - 2176
Опубликована: Май 11, 2023
Abstract
Breast
cancer
is
the
most
malignant
tumor
in
women,
and
there
no
absolute
cure
for
it.
Although
treatment
modalities
including
surgery,
chemotherapy,
radiotherapy
are
utilized
breast
cancer,
it
still
a
life‐threatening
disease
humans.
Nanomedicine
has
provided
new
opportunity
treatment,
which
focus
of
current
study.
The
nanocarriers
deliver
chemotherapeutic
agents
natural
products,
both
increase
cytotoxicity
against
cells
prevent
development
drug
resistance.
efficacy
gene
therapy
boosted
by
nanoparticles
delivery
CRISPR/Cas9,
Noncoding
RNAs,
RNAi,
promoting
their
potential
expression
regulation.
codelivery
can
exert
synergistic
impact
on
tumors
enhance
cellular
uptake
via
endocytosis.
Nanostructures
able
to
induce
photothermal
photodynamic
ablation
cell
death
induction.
provide
microenvironment
remodeling
repolarization
macrophages
antitumor
immunity.
stimuli‐responsive
nanocarriers,
pH‐,
redox‐,
light‐sensitive,
mediate
targeted
suppression
tumors.
Besides,
diagnosis
detect
biomarkers.
Various
kinds
have
been
employed
therapy,
carbon‐,
lipid‐,
polymeric‐
metal‐based
nanostructures,
different
terms
biocompatibility
efficiency.
Chemical Reviews,
Год журнала:
2023,
Номер
123(11), С. 7326 - 7378
Опубликована: Март 13, 2023
Cancer
thermal
therapy,
also
known
as
hyperthermia
has
long
been
exploited
to
eradicate
mass
lesions
that
are
now
defined
cancer.
With
the
development
of
corresponding
technologies
and
equipment,
local
therapies
such
radiofrequency
ablation,
microwave
high-intensity
focused
ultrasound,
have
validated
effectively
ablate
tumors
in
modern
clinical
practice.
However,
they
still
face
many
shortcomings,
including
nonspecific
damages
adjacent
normal
tissues
incomplete
ablation
particularly
for
large
tumors,
restricting
their
wide
usage.
Attributed
versatile
physiochemical
properties,
biomaterials
specially
designed
potentiate
treatments
according
unique
working
principles.
Meanwhile,
biomaterial-based
delivery
systems
able
bridge
with
other
types
treatment
strategies
chemotherapy,
radiotherapy
immunotherapy.
Therefore,
this
review,
we
discuss
recent
progress
functional
reinforce
by
functioning
sensitizers
endow
more
efficient
tumor-localized
and/or
vehicles
synergize
therapeutic
modalities
combined
cancer
treatments.
Thereafter,
provide
a
critical
perspective
on
further
biomaterial-assisted
toward
applications.
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Ноя. 19, 2022
Abstract
Cancer
is
a
major
threat
to
human
health.
Among
various
treatment
methods,
precision
therapy
has
received
significant
attention
since
the
inception,
due
its
ability
efficiently
inhibit
tumor
growth,
while
curtailing
common
shortcomings
from
conventional
cancer
treatment,
leading
towards
enhanced
survival
rates.
Particularly,
organelle-targeted
strategies
enable
precise
accumulation
of
therapeutic
agents
in
organelles,
locally
triggering
organelle-mediated
cell
death
signals
which
can
greatly
reduce
threshold
dosage
and
minimize
side-effects.
In
this
review,
we
comprehensively
discuss
history
recent
advances
targeted
therapies
on
specifically
including
nucleus,
mitochondria,
lysosomes
endoplasmic
reticulum,
focusing
organelle
structures,
signal
pathways,
design
guidelines
nanomedicines
based
intervention
mechanisms.
Furthermore,
perspective
future
research
clinical
opportunities
potential
challenges
oncology
presented.
Through
demonstrating
developments
therapies,
believe
article
further
stimulate
broader
interests
multidisciplinary
technology
development
for
enabling
advanced
their
corresponding
clinic
translations.
