Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 6891 - 6952

Published: May 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Language: Английский

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Nanoagent‐Promoted Mild‐Temperature Photothermal Therapy for Cancer Treatment

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(25)

Published: March 31, 2021

Abstract Photothermal therapy (PTT), which utilizes near‐infrared light‐absorbing agents to ablate tumor, has emerged as a highly promising anticancer strategy and received intensive clinical trials in recent years. Mild‐temperature PTT, circumvents the limitations of conventional PTT (e.g., thermoresistance adverse effects), is emerging shows great potential forthcoming applications. However, mild‐temperature without adjuvant not able completely eradicate tumors because its therapeutic efficacy dramatically impaired by inferior heat intensity. As result, strategies capable enhancing are urgently necessitated, mainly rely on on‐demand fabrication functionalized nanoagents. In this review, nanoagent‐promoted highlighted. Furthermore, challenges opportunities field rationally proposed, hopefully people can be encouraged therapy.

Language: Английский

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Carbon Dots in Bioimaging, Biosensing and Therapeutics: A Comprehensive Review

Small Science, Journal Year: 2022, Volume and Issue: 2(6)

Published: May 8, 2022

Carbon dots (CDs), comprising crystalline graphitized carbon cores and polymer surface groups, are currently attracting a lot of interest in biological fields owing to their fluorescent properties, high photostability, biocompatibility low toxicity. In addition, the easy preparation functionalization CDs stimulate development CDs‐based composite materials with specific functions. Presently, applications growing at remarkable speed, justifying need for up‐to‐date review articles that capture recent progress this blossoming field. review, breakthroughs synthesis, modification, optical toxicology biocatalytic platforms described. Further, research related bioimaging, biosensing, drug delivery, antibacterial, anticancer (photothermal therapy, photodynamic therapy synergistic therapy) antiviral therapies involving discussed detail. Finally, perspective on prospects challenges biomedicine biotechnology is provided.

Language: Английский

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Metalated covalent organic frameworks: from synthetic strategies to diverse applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(15), P. 6307 - 6416

Published: Jan. 1, 2022

This review highlights the recent advances of metalated covalent organic frameworks, including synthetic strategies and applications, discusses current challenges future directions.

Language: Английский

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Inorganic–organic hybrid nanomaterials for photothermal antibacterial therapy

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 496, P. 215426 - 215426

Published: Sept. 6, 2023

Language: Английский

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Multifunctional mesoporous silica nanoparticles for biomedical applications

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 24, 2023

Abstract Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, excellent biocompatibility. Over past two decades, researchers have developed wide variety MSNs-based nanoplatforms through careful design controlled preparation techniques, demonstrating adaptability various application scenarios. With continuous breakthroughs MSNs fields biosensing, disease diagnosis treatment, tissue engineering, etc., gradually moving from basic research clinical trials. In this review, we provide detailed summary beginning with comprehensive overview development history. We then discuss types nanostructured architectures, well classification nanocomposites according elements existed inorganic functional components. Subsequently, summarize primary purposes surface-functionalized modifications MSNs. following, applications MSNs, highlight targeted therapeutic modalities currently developed. Given importance translation, also progress Finally, take perspective on future direction remaining challenges field.

Language: Английский

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Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 190, P. 114536 - 114536

Published: Sept. 13, 2022

Language: Английский

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(Nano)platforms in breast cancer therapy: Drug/gene delivery, advanced nanocarriers and immunotherapy

Medicinal Research Reviews, Journal Year: 2023, Volume and Issue: 43(6), P. 2115 - 2176

Published: May 11, 2023

Abstract Breast cancer is the most malignant tumor in women, and there no absolute cure for it. Although treatment modalities including surgery, chemotherapy, radiotherapy are utilized breast cancer, it still a life‐threatening disease humans. Nanomedicine has provided new opportunity treatment, which focus of current study. The nanocarriers deliver chemotherapeutic agents natural products, both increase cytotoxicity against cells prevent development drug resistance. efficacy gene therapy boosted by nanoparticles delivery CRISPR/Cas9, Noncoding RNAs, RNAi, promoting their potential expression regulation. codelivery can exert synergistic impact on tumors enhance cellular uptake via endocytosis. Nanostructures able to induce photothermal photodynamic ablation cell death induction. provide microenvironment remodeling repolarization macrophages antitumor immunity. stimuli‐responsive nanocarriers, pH‐, redox‐, light‐sensitive, mediate targeted suppression tumors. Besides, diagnosis detect biomarkers. Various kinds have been employed therapy, carbon‐, lipid‐, polymeric‐ metal‐based nanostructures, different terms biocompatibility efficiency.

Language: Английский

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Rational Design of Biomaterials to Potentiate Cancer Thermal Therapy

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 7326 - 7378

Published: March 13, 2023

Cancer thermal therapy, also known as hyperthermia has long been exploited to eradicate mass lesions that are now defined cancer. With the development of corresponding technologies and equipment, local therapies such radiofrequency ablation, microwave high-intensity focused ultrasound, have validated effectively ablate tumors in modern clinical practice. However, they still face many shortcomings, including nonspecific damages adjacent normal tissues incomplete ablation particularly for large tumors, restricting their wide usage. Attributed versatile physiochemical properties, biomaterials specially designed potentiate treatments according unique working principles. Meanwhile, biomaterial-based delivery systems able bridge with other types treatment strategies chemotherapy, radiotherapy immunotherapy. Therefore, this review, we discuss recent progress functional reinforce by functioning sensitizers endow more efficient tumor-localized and/or vehicles synergize therapeutic modalities combined cancer treatments. Thereafter, provide a critical perspective on further biomaterial-assisted toward applications.

Language: Английский

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Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Nov. 19, 2022

Abstract Cancer is a major threat to human health. Among various treatment methods, precision therapy has received significant attention since the inception, due its ability efficiently inhibit tumor growth, while curtailing common shortcomings from conventional cancer treatment, leading towards enhanced survival rates. Particularly, organelle-targeted strategies enable precise accumulation of therapeutic agents in organelles, locally triggering organelle-mediated cell death signals which can greatly reduce threshold dosage and minimize side-effects. In this review, we comprehensively discuss history recent advances targeted therapies on specifically including nucleus, mitochondria, lysosomes endoplasmic reticulum, focusing organelle structures, signal pathways, design guidelines nanomedicines based intervention mechanisms. Furthermore, perspective future research clinical opportunities potential challenges oncology presented. Through demonstrating developments therapies, believe article further stimulate broader interests multidisciplinary technology development for enabling advanced their corresponding clinic translations.

Language: Английский

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