Advanced Functional Materials,
Год журнала:
2023,
Номер
33(21)
Опубликована: Фев. 22, 2023
Abstract
Infectious
diseases
(such
as
wound
infections)
caused
by
pathogenic
microorganisms
can
lead
to
serious
consequences
and
even
threaten
life.
The
emergence
of
drug‐resistant
bacteria
has
severely
prevented
the
validity
traditional
antibiotics.
Therefore,
developing
novel
antimicrobial
strategies
without
holds
great
promise
for
maximizing
efficacy
minimizing
risk
drug‐resistance
resistant
bacterial
infections.
Herein,
near‐infrared
(NIR)‐absorbing
A–D–A
type
conjugated
oligomers
with
a
tunable
backbone
are
designed
synthesized
regulating
their
photothermal
conversion.
After
being
assembled
into
nanoparticles,
oligomer
CP‐F8P
nanoparticles
(NPs)
containing
strong
electron‐donating
component
show
strongest
conversion
efficiency
81.6%.
low
concentration
NPs
receive
over
99%
against
Amp
r
E.
coli
,
S.
aureus
C.
albicans
upon
NIR
irradiation,
phototherapy
treatment
effectively
promote
healing
in
diabetic
mice
good
biocompatibility.
This
work
provides
ideas
design
efficient
NIR‐activated
reagents
microbial
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(29)
Опубликована: Июнь 9, 2023
Abstract
Growing
concern
about
photothermal
tumor
therapy
(PTT)
as
a
promising
alternative
to
conventional
liver
cancer
treatment,
which
is
treatment
strategy
that
utilizes
near‐infrared
(NIR)
light‐induced
agents
(PTAs)
yield
effects
localize
thermal
damage
for
tumors.
Herein,
given
the
gap
between
experimental
research
and
clinical
application,
this
review
seeks
timely
summarize
highlight
recent
progress
of
PTAs
used
in
vivo
vitro
last
five‐year.
The
implications
various
on
multifunctional
conversion
capability,
structure‐performance
correlations
PTT,
together
with
evaluation
their
potential
application
are
systematically
dissected
further
dig
out
what
buried
mechanism
is.
Besides,
higher
requirements
put
forward
discrepancies
crucial
issues
faced
by
different
PTT
related
medical
technical
obstacles
being
conquered,
lays
solid
theoretical
foundation
field
oncology
whole,
especially
cancer.
Finally,
it
expected
can
present
valuable
guidance
design
efficient,
photostability,
biosafety‐aware
anticancer
while
stepping
into
fast
traffic
lane
from
bench
bedside
foreseeable
future.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(21)
Опубликована: Фев. 22, 2023
Abstract
Infectious
diseases
(such
as
wound
infections)
caused
by
pathogenic
microorganisms
can
lead
to
serious
consequences
and
even
threaten
life.
The
emergence
of
drug‐resistant
bacteria
has
severely
prevented
the
validity
traditional
antibiotics.
Therefore,
developing
novel
antimicrobial
strategies
without
holds
great
promise
for
maximizing
efficacy
minimizing
risk
drug‐resistance
resistant
bacterial
infections.
Herein,
near‐infrared
(NIR)‐absorbing
A–D–A
type
conjugated
oligomers
with
a
tunable
backbone
are
designed
synthesized
regulating
their
photothermal
conversion.
After
being
assembled
into
nanoparticles,
oligomer
CP‐F8P
nanoparticles
(NPs)
containing
strong
electron‐donating
component
show
strongest
conversion
efficiency
81.6%.
low
concentration
NPs
receive
over
99%
against
Amp
r
E.
coli
,
S.
aureus
C.
albicans
upon
NIR
irradiation,
phototherapy
treatment
effectively
promote
healing
in
diabetic
mice
good
biocompatibility.
This
work
provides
ideas
design
efficient
NIR‐activated
reagents
microbial
