Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(27), С. 6201 - 6224
Опубликована: Янв. 1, 2023
This review article provides an overview of types wound dressings, wound-dressing materials, advanced fabrication techniques, and key features applications transparent dressings for the healing process, as well how they can improve outcomes.
Язык: Английский
Asian Journal of Pharmaceutical Sciences, Год журнала: 2022, Номер 17(3), С. 353 - 384
Опубликована: Янв. 24, 2022
Bacterial infection and the ever-increasing bacterial resistance have imposed severe threat to human health. And contamination could significantly menace wound healing process. Considering sophisticated process, novel strategies for skin tissue engineering are focused on integration of bioactive ingredients, antibacterial agents included, into biomaterials with different morphologies improve cell behaviors promote healing. However, a comprehensive review anti-bacterial dressing enhance has not been reported. In this review, various as dressings will be discussed. Different kinds agents, including antibiotics, nanoparticles (metal metallic oxides, light-induced agents), cationic organic others, their recent advances summarized. Biomaterial selection fabrication structures forms, films, hydrogel, electrospun nanofibers, sponge, foam three-dimension (3D) printed scaffold regeneration, elaborated Current challenges future perspectives presented in multidisciplinary field. We envision that provide general insight elegant design further refinement dressing.
Язык: Английский
Процитировано
342
Bioactive Materials, Год журнала: 2021, Номер 9, С. 461 - 474
Опубликована: Июль 26, 2021
Bacterial infection, tissue hypoxia and inflammatory response can hinder the infected wound repair process. To mitigate above issues, tannic acid-chelated Fe-decorated molybdenum disulfide nanosheets (MoS2@TA/Fe NSs) with dual enzyme activities were developed anchored to a multifunctional hydrogel. The hydrogel exhibited excellent antibacterial ability owing combined effects of photothermal therapy (PTT), glutathione (GSH) loss, peroxidase (POD)-like activity (catalyse H2O2 into ·OH under acid condition) MoS2@TA/Fe NSs. Benefitting from catalase (CAT)-like activity, could decompose O2 at neutral pH relieve supply adequate O2. POD-like was mainly attributed MoS2 NSs, while CAT-like primarily due TA/Fe complex. Moreover, NSs endowed outstanding anti-oxidant scavenge redundant reactive oxygen species (ROS) nitrogen (RNS) environment maintain balance antioxidant systems prevent inflammation. In addition, inhibit release factors for anti-inflammatory property TA. TA retained partial phenolic hydroxyl groups, which cross-linked network structure promoted adhesion hydrogels. Due dynamic boron ester bonds between polyvinyl alcohol (PVA), dextran (Dex), MoS2@TA/Fe, borax, demonstrated fast self-healing rapid shape adaptability. This shape-adaptable adhesive fill whole closely contact wound, ensuring that it achieved its functions maximum efficiency. nanozyme-anchored showed high potential bacteria-infected healing.
Язык: Английский
Процитировано
251
Chemical Society Reviews, Год журнала: 2022, Номер 51(15), С. 6307 - 6416
Опубликована: Янв. 1, 2022
This review highlights the recent advances of metalated covalent organic frameworks, including synthetic strategies and applications, discusses current challenges future directions.
Язык: Английский
Процитировано
221
Advanced Healthcare Materials, Год журнала: 2021, Номер 10(13)
Опубликована: Май 29, 2021
Abstract Chronic wounds, such as the diabetic ulcer wounds have serious effect on people's lives, and can even lead to death. Diabetic are different from normal much easier be infected induce oxidative stress due special surrounding microenvironment, which makes it necessary prepare materials with antibacterial property antioxidant activity simultaneously. The molybdenum disulfide‐ceria (MoS 2 ‐CeO ) nanocomposite possesses both photo‐thermal therapy (PTT) capability of polyethylene glycol modified disulfide nanosheets cerium dioxide nanoparticles (CeO NPs). By combining inherent CeO NPs, MoS exhibits excellent PTT against gram‐positive gram‐negative bacteria through 808 nm laser treatment, thereby reducing risk wound infection. Owing abundant oxygen vacancies in Ce 3+ 4+ transform reversibly endows remarkable ability clear away excessive reactive species around promote healing. results demonstrate that is a promising class for clinical treatment chronic especially used switch.
Язык: Английский
Процитировано
156
Chemical Reviews, Год журнала: 2023, Номер 123(22), С. 12371 - 12430
Опубликована: Авг. 24, 2023
Nowadays, the increasing emergence of antibiotic-resistant pathogenic microorganisms requires search for alternative methods that do not cause drug resistance. Phototherapy strategies (PTs) based on photoresponsive materials have become a new trend in inactivation due to their spatiotemporal controllability and negligible side effects. Among those phototherapy strategies, photocatalytic antimicrobial therapy (PCAT) has emerged as an effective promising strategy recent years. In process treatment, are excited by different wavelengths lights produce reactive oxygen species (ROS) or other toxic killing various microbes, such bacteria, viruses, fungi, parasites, algae. Therefore, this review timely summarizes latest progress PCAT field, with emphasis development antimicrobials (PCAMs), underlying mechanisms, design multiple practical applications local infections therapy, personal protective equipment, water purification, coatings, wound dressings, food safety, antibacterial textiles, air purification. Meanwhile, we also present challenges perspectives widespread implementation therapeutics. We hope result review, will flourish weapon against antibiotic
Язык: Английский
Процитировано
150
Journal of the American Chemical Society, Год журнала: 2021, Номер 143(43), С. 17891 - 17909
Опубликована: Окт. 22, 2021
The emergence of multi-drug-resistant pathogens threatens the healthcare systems world-wide. Recent advances in phototherapy (PT) approaches mediated by photo-antimicrobials (PAMs) provide new opportunities for current serious antibiotic resistance. During PT treatment, reactive oxygen species or heat produced PAMs would react with cell membrane, consequently leaking cytoplasm components and effectively eradicating different like bacteria, fungi, viruses, even parasites. This Perspective will concentrate on development organic (OPAMs) their application as practical therapeutic agents into therapy local infections, wound dressings, removal biofilms from medical devices. We also discuss how to design highly efficient OPAMs modifying chemical structure conjugating a targeting component. Moreover, this provides discussion general challenges direction what further needs be done. It is hoped that through overview, can prosper more widely used microbial infections future, especially at time when global COVID-19 epidemic getting serious.
Язык: Английский
Процитировано
127
Small, Год журнала: 2021, Номер 17(32)
Опубликована: Июль 3, 2021
Chemodynamic therapy (CDT), which induces cell death by decomposing high levels of H2 O2 in tumor cells into highly toxic ·OH, is recognized as a promising antineoplastic approach. However, current CDT approaches are often restricted the controlled and upregulated cellular antioxidant defense. To enhance ·OH-induced damage CDT, covalent organic framework (COF)-based, ferrocene (Fc)- glutathione peroxidase 4 (GPX4) inhibitor-loaded nanodrug, RSL3@COF-Fc (2b), fabricated. The obtained 2b not only promotes situ Fenton-like reactions to trigger ·OH production cells, but also attenuates repair mechanisms under oxidative stress via irreversible GPX4 inhibition. As result, these two synergistically result massive lipid peroxide accumulation, subsequent damage, ultimately ferroptosis, while being limited intracellular glutathione. It believed that this research provides paradigm for enhancing reactive oxygen species-mediated oncotherapy through redox dyshomeostasis may provide new insights developing COF-based nanomedicine.
Язык: Английский
Процитировано
121
Chemical Society Reviews, Год журнала: 2021, Номер 51(1), С. 43 - 56
Опубликована: Дек. 3, 2021
Porous organic polymers (POPs) are prepared by crosslinked polymerization of multidimensional rigid aromatic building blocks followed PSM depending on the application.
Язык: Английский
Процитировано
112
ACS Applied Materials & Interfaces, Год журнала: 2021, Номер 13(23), С. 26651 - 26672
Опубликована: Июнь 4, 2021
Visible-light irradiation of porphyrin and metalloporphyrin dyes in the presence molecular oxygen can result photocatalytic generation singlet (1O2). This type II reactive species (ROS) finds many applications where dye, also called photosensitizer, is dissolved (i.e., homogeneous phase) along with substrate to be oxidized. In contrast, metal-organic frameworks (MOFs) are insoluble (or will disassemble) when placed a solvent. When stable as suspension, MOFs adsorb large amount O2 photocatalytically generate 1O2 heterogeneous process efficiently. Considering immense surface area great capacity for gas adsorption MOFs, they seem ideal candidates this application. Very recently, covalent-organic (COFs), variants reticulation relies on covalent rather than coordination bonds, have emerged efficient photosensitizers. comprehensive mini review describes recent developments use porphyrin-based or porphyrin-containing COFs, including nanosized versions, photosensitizers toward antimicrobial applications.
Язык: Английский
Процитировано
111
Progress in Polymer Science, Год журнала: 2023, Номер 142, С. 101691 - 101691
Опубликована: Май 6, 2023
Язык: Английский
Процитировано
81