Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(27)
Опубликована: Июль 27, 2024
Abstract
The
threat
posed
by
antibiotic‐resistant
bacteria
and
the
challenge
of
biofilm
formation
has
highlighted
inadequacies
conventional
antibacterial
therapies,
leading
to
increased
interest
in
photodynamic
therapy
(aPDT)
recent
years.
This
approach
offers
advantages
such
as
minimal
invasiveness,
low
systemic
toxicity,
notable
effectiveness
against
drug‐resistant
bacterial
strains.
Porphyrins
their
derivatives,
known
for
high
molar
extinction
coefficients
singlet
oxygen
quantum
yields,
have
emerged
crucial
photosensitizers
aPDT.
However,
practical
application
is
hindered
challenges
poor
water
solubility
aggregation‐induced
quenching.
To
address
these
limitations,
extensive
research
focused
on
development
porphyrin‐based
nanomaterials
aPDT,
enhancing
efficacy
sterilization
broadening
range
antimicrobial
activity.
review
provides
an
overview
various
utilized
aPDT
eradication
years,
including
porphyrin‐loaded
inorganic
nanoparticles,
polymer
assemblies,
supramolecular
metal–organic
frameworks
(MOFs),
covalent
organic
(COFs).
Additionally,
insights
into
prospects
offered,
highlighting
its
potential
implementation.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(9), С. 3324 - 3340
Опубликована: Янв. 1, 2022
This
tutorial
review
highlights
the
concept
and
significance
of
antibacterial
phototherapy.
Recent
developments,
advantages,
challenges
organic
photosensitizers
in
this
area
are
also
discussed.
Chemical Reviews,
Год журнала:
2023,
Номер
123(22), С. 12371 - 12430
Опубликована: Авг. 24, 2023
Nowadays,
the
increasing
emergence
of
antibiotic-resistant
pathogenic
microorganisms
requires
search
for
alternative
methods
that
do
not
cause
drug
resistance.
Phototherapy
strategies
(PTs)
based
on
photoresponsive
materials
have
become
a
new
trend
in
inactivation
due
to
their
spatiotemporal
controllability
and
negligible
side
effects.
Among
those
phototherapy
strategies,
photocatalytic
antimicrobial
therapy
(PCAT)
has
emerged
as
an
effective
promising
strategy
recent
years.
In
process
treatment,
are
excited
by
different
wavelengths
lights
produce
reactive
oxygen
species
(ROS)
or
other
toxic
killing
various
microbes,
such
bacteria,
viruses,
fungi,
parasites,
algae.
Therefore,
this
review
timely
summarizes
latest
progress
PCAT
field,
with
emphasis
development
antimicrobials
(PCAMs),
underlying
mechanisms,
design
multiple
practical
applications
local
infections
therapy,
personal
protective
equipment,
water
purification,
coatings,
wound
dressings,
food
safety,
antibacterial
textiles,
air
purification.
Meanwhile,
we
also
present
challenges
perspectives
widespread
implementation
therapeutics.
We
hope
result
review,
will
flourish
weapon
against
antibiotic
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(23)
Опубликована: Март 25, 2022
Abstract
We
report
a
cationic
porphyrin
5,10,15,20‐tetrakis‐(4‐
N
‐methylpyridyl)‐porphyrin
(TMPyP)
that
can
respond
to
specific
bacteria,
followed
by
adaptable
photodynamic/photothermal
therapy
processes.
TMPyP
could
be
reduced
phlorin
facultative
anaerobes
with
strong
reducing
ability
such
as
E.
coli
and
S.
typhimurium
in
hypoxic
environments,
possessing
NIR
absorption
remarkable
photothermal
conversion
capacity,
thus
demonstrating
excellent
antimicrobial
activity
(>99
%)
therapy.
While
an
aerobic
environment
functioned
typical
photosensitizer
killed
bacteria
effectively
(>99.9
photodynamic
By
forming
host–guest
complex
cucurbit[7]uril,
the
biocompatibility
of
significantly
improved.
This
kind
bacteria‐responsive
shows
specificity
adaptivity
treatment
holds
potential
non‐invasive
treatments
bacterial
infections.
Advanced Materials,
Год журнала:
2024,
Номер
36(35)
Опубликована: Июнь 24, 2024
While
the
construction
of
a
donor-acceptor
(D-A)
structure
has
gained
great
attention
across
various
scientific
disciplines,
such
structures
are
seldomly
reported
within
field
hydrogen-bonded
organic
frameworks
(HOFs).
Herein,
D-A
based
HOF
is
synthesized,
where
adjacent
pairs
connected
by
hydrogen
bonds
instead
conventionally
employed
covalent
bonds.
This
structural
feature
imparts
material
with
reduced
energy
gap
between
excited
state
and
triplet
state,
thereby
facilitating
intersystem
crossing
(ISC)
boosting
generation
rate
single
oxygen
(quantum
yield
=
0.98).
Consequently,
resulting
shows
high
performance
for
antimicrobial
photodynamic
therapy
(PDT).
The
impact
moiety
evident
when
comparing
this
finding
to
parallel
study
conducted
on
an
isoreticular
without
structure.
presented
here
provides
in-depth
insights
into
photophysical
properties
pair
in
network,
opening
new
avenue
design
innovative
materials
efficient
PDT.
