Frontiers in Public Health,
Год журнала:
2023,
Номер
11
Опубликована: Июль 6, 2023
Degeneration
of
the
intervertebral
disc
(IVD)
is
a
normal
part
aging.
Due
to
spine's
declining
function
and
development
pain,
it
may
affect
one's
physical
health,
mental
socioeconomic
status.
Most
degeneration
(IVDD)
therapies
today
focus
on
symptoms
low
back
pain
rather
than
underlying
etiology
or
mechanical
disc.
The
deteriorated
typically
not
restored
by
conservative
surgical
that
largely
correcting
structural
abnormalities.
To
enhance
clinical
outcome
quality
life
patient,
several
therapeutic
modalities
have
been
created.
In
this
review,
we
discuss
genetic
environmental
causes
IVDD
describe
promising
modern
endogenous
exogenous
approaches
including
their
applicability
relevance
process.
Ageing Research Reviews,
Год журнала:
2024,
Номер
98, С. 102323 - 102323
Опубликована: Май 9, 2024
Oxidative
stress
is
one
of
the
main
driving
mechanisms
intervertebral
disc
degeneration(IDD).
has
been
associated
with
inflammation
in
disc,
cellular
senescence,
autophagy,
and
epigenetics
cells.
It
above
pathological
are
closely
linked
through
common
hub
reactive
oxygen
species(ROS),
promote
each
other
process
degeneration
development
disease.
This
reveals
important
role
oxidative
IDD,
importance
great
potential
IDD
therapy
targeting
stress.
The
efficacy
traditional
unstable
or
cannot
be
maintained.
In
recent
years,
due
to
rise
materials
science,
many
bioactive
functional
have
applied
treatment
combination
drugs,
satisfactory
achieved.
At
present,
research
review
antioxidant
not
complete.
Based
on
existing
studies,
mechanism
were
summarized
this
paper,
strategies
based
emerging
reviewed.
Periodontology 2000,
Год журнала:
2024,
Номер
94(1), С. 257 - 414
Опубликована: Фев. 1, 2024
Abstract
Exosomes
are
the
smallest
subset
of
extracellular
signaling
vesicles
secreted
by
most
cells
with
ability
to
communicate
other
tissues
and
cell
types
over
long
distances.
Their
use
in
regenerative
medicine
has
gained
tremendous
momentum
recently
due
their
be
utilized
as
therapeutic
options
for
a
wide
array
diseases/conditions.
Over
5000
publications
currently
being
published
yearly
on
this
topic,
number
is
only
expected
dramatically
increase
novel
strategies
continue
developed.
Today
exosomes
have
been
applied
numerous
contexts
including
neurodegenerative
disorders
(Alzheimer's
disease,
central
nervous
system,
depression,
multiple
sclerosis,
Parkinson's
post‐traumatic
stress
disorders,
traumatic
brain
injury,
peripheral
nerve
injury),
damaged
organs
(heart,
kidney,
liver,
stroke,
myocardial
infarctions,
ovaries),
degenerative
processes
(atherosclerosis,
diabetes,
hematology
musculoskeletal
degeneration,
osteoradionecrosis,
respiratory
disease),
infectious
diseases
(COVID‐19,
hepatitis),
procedures
(antiaging,
bone
regeneration,
cartilage/joint
osteoarthritis,
cutaneous
wounds,
dental
dermatology/skin
erectile
dysfunction,
hair
regrowth,
intervertebral
disc
repair,
spinal
cord
vascular
regeneration),
cancer
therapy
(breast,
colorectal,
gastric
osteosarcomas),
immune
function
(allergy,
autoimmune
regulation,
inflammatory
diseases,
lupus,
rheumatoid
arthritis).
This
scoping
review
first
its
kind
aimed
at
summarizing
extensive
potential
broad
range
disorders.
Intervertebral
disc
degeneration
(IVDD)
is
a
significant
contributor
to
low
back
pain,
characterized
by
excessive
reactive
oxygen
species
generation
and
inflammation-induced
pyroptosis.
Unfortunately,
there
are
currently
no
specific
molecules
or
materials
available
effectively
delay
IVDD.
This
study
develops
multifunctional
full
name
of
PG@Cu
nanoparticle
network
(PG@Cu).
A
designed
pentapeptide,
bonded
on
nanoparticles
via
Schiff
base
bond,
imparts
multifunctionality
the
metal
polyphenol
particles
(PG@Cu-FP).
PG@Cu-FP
exhibits
enhanced
escape
from
lysosomal
capture,
enabling
efficient
targeting
mitochondria
scavenge
excess
species.
The
scavenging
activity
against
originates
polyphenol-based
structures
within
nanoparticles.
Furthermore,
Pyroptosis
blocked
inhibiting
Gasdermin
mediated
pore
formation
membrane
rupture.
successfully
reduces
activation
nucleotide-binding
oligomerization
domain-like
receptor
family
pyrin
domain-containing
3
inflammasome
protein
(Gasdermin
D,
GSDMD)
oligomerization,
leading
reduced
expression
Nod-like
receptors.
multifaceted
approach
demonstrates
higher
efficiency
in
Pyroptosis.
Experimental
results
confirm
that
preserves
height,
retains
water
content,
tissue
structure.
These
findings
highlight
potential
improving
IVDD
provide
novel
insights
for
future
research
treatments.
Nucleus
pulposus
stem
cells
(NPSCs)
senescence
plays
a
critical
role
in
the
progression
of
intervertebral
disc
degeneration
(IDD).
Stem
cell-derived
extracellular
vesicles
(EV)
alleviate
cellular
senescence.
Whereas,
underlying
mechanism
remains
unclear.
Low
stability
largely
limited
administration
EV
vivo.
RGD,
an
arginine-glycine-aspartic
acid
tripeptide,
strongly
binds
integrins
expressed
on
membranes,
allowing
RGD
to
anchor
and
prolong
their
bioavailability.
An
RGD-complexed
nucleus
matrix
hydrogel
(RGD-DNP)
is
developed
enhance
therapeutic
effects
small
(sEV).
RGD-DNP
prolonged
sEV
retention
vitro
ex
sEV-RGD-DNP
promoted
NPSCs
migration,
decreased
number
SA-β-gal-positive
cells,
alleviated
cell
cycle
arrest,
reduced
p16,
p21,
p53
activation.
Small
RNA-seq
showed
that
miR-3594-5p
enriched
sEV,
targets
homeodomain-interacting
protein
kinase
2
(HIPK2)/p53
pathway.
The
HIPK2
knockdown
rescues
impaired
with
downregulated
miR-3594-5p.
conjugate
lower
amounts
achieved
similar
regeneration
free
higher
concentrations
DNP.
In
conclusion,
increases
bioavailability
relieves
by
targeting
HIPK2/p53
pathway,
thereby
alleviating
IDD.
This
work
achieves
better
regenerative
fewer
consolidates
theoretical
basis
for
application
IDD
treatment.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 1597 - 1627
Опубликована: Фев. 1, 2024
Abstract:
The
development
of
numerous
diseases
is
significantly
influenced
by
inflammation.
Macrophage-derived
exosomes
(M-Exos)
play
a
role
in
controlling
inflammatory
reactions
various
conditions,
including
chronic
pain,
hypertension,
and
diabetes.
However,
the
specific
targets
roles
M-Exos
regulating
inflammation
remain
largely
unknown.
This
review
summarizes
current
knowledge
on
biogenesis
provides
updated
information
M-Exos'
biological
function
modulation.
Furthermore,
this
highlights
functionalization
engineering
strategies
M-Exos,
while
providing
an
overview
cutting-edge
approaches
to
advancements
their
application
as
therapeutics
for
Finally,
multiple
mechanisms
are
presented
along
with
perspectives
challenges,
potential
contribution
that
may
have
through
modulation
discussed.
Keywords:
inflammation,
macrophage-derived
exosomes,
functions,
modulation,
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
172, С. 116238 - 116238
Опубликована: Фев. 3, 2024
Intervertebral
disc
degeneration
(IDD)
is
a
disease
that
severely
affects
spinal
health
and
prevalent
worldwide.
Mesenchymal
stem
cells
(MSCs)
their
derived
extracellular
vesicles
(EVs)
have
regenerative
potential
emerged
as
promising
therapeutic
tools
for
treating
degenerative
discs.
However,
challenges
such
the
harsh
microenvironment
of
degenerated
intervertebral
discs
EVs'
limited
stability
efficacy
hindered
clinical
application.
In
recent
years,
hydrogels
attracted
much
attention
in
field
IDD
therapy
because
they
can
mimic
physiologic
provide
solution
by
providing
suitable
growth
environment
MSCs
EVs.
This
review
introduced
biological
properties
EVs,
summarized
research
on
application
EVs
IDD,
current
trial
studies
also
explored
mechanism
action
addition,
plenty
elaborated
different
classified
tissue
engineering,
synergistic
effect
promoting
regeneration,
wide
IDD.
Finally,
problems
still
faced
hydrogel-loaded
treatment
are
summarized,
solutions
proposed.
paper
outlines
effects
combination
with
aims
to
theoretical
references
future
related
studies.
