Ageing Research Reviews,
Год журнала:
2023,
Номер
92, С. 102094 - 102094
Опубликована: Окт. 18, 2023
As
a
global
public
health
problem,
low
back
pain
(LBP)
caused
by
intervertebral
disc
degeneration
(IDD)
seriously
affects
patients'
quality
of
life.
In
addition,
the
prevalence
IDD
tends
to
be
younger,
which
brings
huge
burden
individuals
and
society
economically.
Current
treatments
do
not
delay
or
reverse
progression
IDD.
The
emergence
biologic
therapies
has
brought
new
hope
for
treatment
Among
them,
extracellular
vesicles
(EVs),
as
nanoscale
bioactive
substances
that
mediate
cellular
communication,
have
now
produced
many
surprising
results
in
research
This
article
reviews
mechanisms
roles
EVs
delaying
describes
prospects
challenges
EVs.
Bioactive Materials,
Год журнала:
2024,
Номер
38, С. 1 - 30
Опубликована: Апрель 23, 2024
Characterized
by
their
pivotal
roles
in
cell-to-cell
communication,
cell
proliferation,
and
immune
regulation
during
tissue
repair,
exosomes
have
emerged
as
a
promising
avenue
for
"cell-free
therapy"
clinical
applications.
Hydrogels,
possessing
commendable
biocompatibility,
degradability,
adjustability,
physical
properties
akin
to
biological
tissues,
also
found
extensive
utility
engineering
regenerative
repair.
The
synergistic
combination
of
hydrogels
holds
the
potential
not
only
enhance
efficiency
but
collaboratively
advance
repair
process.
This
review
has
summarized
advancements
made
over
past
decade
research
hydrogel-exosome
systems
regenerating
various
tissues
including
skin,
bone,
cartilage,
nerves
tendons,
with
focus
on
methods
encapsulating
releasing
within
hydrogels.
It
critically
examined
gaps
limitations
current
research,
whilst
proposed
future
directions
applications
this
innovative
approach.
Abstract
Osteoporosis
is
a
systemic
and
degenerative
disease
characterized
by
low
bone
mass
fragile
microarchitecture,
which
predispose
patients
to
fragility
fractures,
also
known
as
osteoporotic
fractures
(OPF).
OPF
have
become
major
social
problem
that
threaten
the
health
of
elderly.
Over
past
decade,
organoids
extracellular
vesicles
(OEVs)
play
significant
role
in
repair.
Organoids
been
widely
used
for
treatment.
Moreover,
EVs
are
promising
nanocarriers
due
their
cell‐free
system,
stable
drug
loading
capacity,
nanometer
size,
good
biocompatibility.
Importanly,
compared
with
traditional
EVs,
OEVs
more
quantity,
better
physiological
effects,
therapeutic
effects.
Therefore,
development
organoid
treatment
great
significance.
Here,
we
summarize
current
status
future
perspectives
OEVs,
will
provide
innovative
solutions
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
172, С. 116238 - 116238
Опубликована: Фев. 3, 2024
Intervertebral
disc
degeneration
(IDD)
is
a
disease
that
severely
affects
spinal
health
and
prevalent
worldwide.
Mesenchymal
stem
cells
(MSCs)
their
derived
extracellular
vesicles
(EVs)
have
regenerative
potential
emerged
as
promising
therapeutic
tools
for
treating
degenerative
discs.
However,
challenges
such
the
harsh
microenvironment
of
degenerated
intervertebral
discs
EVs'
limited
stability
efficacy
hindered
clinical
application.
In
recent
years,
hydrogels
attracted
much
attention
in
field
IDD
therapy
because
they
can
mimic
physiologic
provide
solution
by
providing
suitable
growth
environment
MSCs
EVs.
This
review
introduced
biological
properties
EVs,
summarized
research
on
application
EVs
IDD,
current
trial
studies
also
explored
mechanism
action
addition,
plenty
elaborated
different
classified
tissue
engineering,
synergistic
effect
promoting
regeneration,
wide
IDD.
Finally,
problems
still
faced
hydrogel-loaded
treatment
are
summarized,
solutions
proposed.
paper
outlines
effects
combination
with
aims
to
theoretical
references
future
related
studies.
Stem
cell-derived
exosomes
exert
comparable
therapeutic
effects
to
those
of
their
parental
stem
cells
without
causing
immunogenic,
tumorigenic,
and
ethical
disadvantages.
Their
advantages
are
manifested
in
the
management
a
broad
spectrum
diseases,
dosing
versatility
exemplified
by
systemic
administration
local
delivery.
Furthermore,
activation
regulation
various
signaling
cascades
have
provided
foundation
for
claimed
curative
exosomal
therapy.
Unlike
other
relevant
reviews
focusing
on
upstream
aspects
(e.g.,
yield,
isolation,
modification),
downstream
(e.g.
phenotypic
changes,
tissue
response,
cellular
behavior)
exosome
therapy,
this
unique
review
endeavors
focus
affected
pathways.
After
meticulous
dissection
literature
from
past
five
years,
we
present
comprehensive,
up-to-date,
disease-specific,
pathway-oriented
review.
Exosomes
sourced
types
can
regulate
major
pathways
PTEN/PI3K/Akt/mTOR,
NF-κB,
TGF-β,
HIF-1α,
Wnt,
MAPK,
JAK-STAT,
Hippo,
Notch
cascades)
minor
during
treatment
numerous
diseases
encountered
orthopedic
surgery,
neurosurgery,
cardiothoracic
plastic
general
specialties.
We
provide
novel
perspective
future
research
through
bridging
gap
between
surgical
indications
when
designing
further
preclinical
studies
clinical
trials.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 24, 2023
Injectable
hydrogels
offer
minimally-invasive
treatment
options
for
degenerative
disc
disease,
a
prevalent
condition
affecting
millions
annually.
Many
explored
intervertebral
(IVD)
repair
suffer
from
weak
mechanical
integrity,
migration
issues,
and
expulsion.
To
overcome
these
limitations,
an
injectable
radiopaque
hyaluronic
acid
granular
hydrogel
is
developed.
The
structure
provides
easy
injectability
low
extrusion
forces,
while
the
radiopacity
enables
direct
visualization
during
injection
into
non-invasive
monitoring
after
injection.
injected
rabbit
explants
to
investigate
restoration
of
healthy
mechanics
following
needle
puncture
injury
ex
vivo
then
delivered
in
manner
intradiscal
space
clinically-relevant
large
animal
goat
model
IVD
degeneration
initiated
through
degradation
by
chondroitinase.
successfully
halted
loss
height
due
degeneration.
Further,
not
only
enhanced
proteoglycan
content
reduced
collagen
nucleus
pulposus
(NP)
region
compared
discs,
but
also
helped
maintain
structural
integrity
promote
segregation
NP
annulus
fibrosus
regions.
Overall,
this
study
demonstrates
great
potential
disease.
Abstract
Cellular
senescence
is
a
significant
contributor
to
intervertebral
disc
aging
and
degeneration.
However,
the
application
of
senotherapies,
such
as
senomorphics
targeting
markers
senescence‐associated
secretory
phenotype
(SASP),
remains
limited
due
challenges
in
precise
delivery.
Given
that
natural
killer
group
2D
(NKG2D)
ligands
are
increased
on
surface
senescent
nucleus
pulposus
(NP)
cells,
NKG2D‐overexpressing
NP
cell
membranes
(NNPm)
constructed,
which
expected
achieve
dual
effect
toward
cells
based
homologous
membrane
fusion
NKG2D‐mediated
immunosurveillance
mechanism.
Then,
mesoporous
silica
nanoparticles
carrying
peroxisome
proliferator‐activated
receptor‐ɣ
coactivator
1α
(PGC1α)inducer
(SP)
coated
with
NNPm
(SP@NNPm)
it
found
SP@NNPm
selectively
targets
SP
cores
exhibit
pH‐responsive
drug
release.
Moreover,
effectively
induces
PGC1α‐mediated
mitochondrial
biogenesis
mitigates
induced
by
oxidative
stress
SASP,
thereby
alleviating
puncture‐induced
This
dual‐targeting
nanotherapeutic
system
represents
novel
approach
delivery
for
degeneration
treatment.
