Ceria‐Based Therapeutic Antioxidants for Biomedical Applications

Advanced Materials, Год журнала: 2023, Номер 36(10)

Опубликована: Фев. 16, 2023

Abstract The growing interest in nanomedicine over the last 20 years has carved out a research field called “nanocatalytic therapy,” where catalytic reactions mediated by nanomaterials are employed to intervene disease‐critical biomolecular processes. Among many kinds of catalytic/enzyme‐mimetic investigated thus far, ceria nanoparticles stand from others owing their unique scavenging properties against biologically noxious free radicals, including reactive oxygen species (ROS) and nitrogen (RNS), exerting enzyme mimicry nonenzymatic activities. Much effort been made utilize as self‐regenerating antioxidative anti‐inflammatory agents for various diseases, given detrimental effects ROS RNS therein that need alleviation. In this context, review is intended provide an overview what makes merit attention disease therapy. introductory part describes characteristics oxygen‐deficient metal oxide. pathophysiological roles then presented, well mechanisms nanoparticles. Representative examples recent ceria‐nanoparticle‐based therapeutics summarized categorization into organ types, followed discussion on remaining challenges future directions.

Язык: Английский

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Nanomaterials-modulated Fenton reactions: Strategies, chemodynamic therapy and future trends

Chemical Engineering Journal, Год журнала: 2023, Номер 466, С. 142960 - 142960

Опубликована: Апрель 15, 2023

Язык: Английский

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Biocatalytic cascade in tumor microenvironment with a Fe2O3/Au hybrid nanozyme for synergistic treatment of triple negative breast cancer

Chemical Engineering Journal, Год журнала: 2022, Номер 452, С. 138422 - 138422

Опубликована: Авг. 2, 2022

Язык: Английский

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Nanomaterials-based photosensitizers and delivery systems for photodynamic cancer therapy

Biomaterials Advances, Год журнала: 2022, Номер 135, С. 212725 - 212725

Опубликована: Апрель 1, 2022

Язык: Английский

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Strategies to engineer various nanocarrier-based hybrid catalysts for enhanced chemodynamic cancer therapy

Chemical Society Reviews, Год журнала: 2023, Номер 52(22), С. 7707 - 7736

Опубликована: Янв. 1, 2023

This review summarizes the strategies to engineer CDT nanocatalysts based on diverse nanocarriers, especially those with intrinsic therapeutic activities.

Язык: Английский

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Hydrogen Sulfide Gas Amplified ROS Cascade: FeS@GOx Hybrid Nanozyme Designed for Boosting Tumor Chemodynamic Immunotherapy

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(23)

Опубликована: Апрель 11, 2023

Chemodynamic immunotherapy that utilizes catalysts to produce reactive oxygen species (ROS) for killing tumor cells and arousing antitumor immunity has received considerable attention. However, it is still restricted by low ROS production efficiency insufficient immune activation, due intricate redox homeostasis in the microenvironment (TME). Herein, a metalloprotein-like hybrid nanozyme (FeS@GOx) designed situ growth of (ferrous sulfide, FeS) natural enzyme (glucose oxidase, GOx) amplify cascade boosting chemodynamic immunotherapy. In FeS@GOx, GOx allows conversion endogenous glucose gluconic acid hydrogen peroxide, which provides favorable increasing peroxide subsequent Fenton reaction FeS nanozymes, thus reinforcing production. Notably, sulfide (H2 S) release activated generation-related pH decrease, can suppress activity thioredoxin reductase catalase further inhibit elimination. Thus, FeS@GOx sustainably accumulation perturb intracellular improve therapy trigger robust immunogenic cell death effective combined with checkpoint blockade. This work proposes feasible H2 S amplified strategy employing bioinspired nanozyme, providing novel pathway multi-enzyme-mediated TME modulation precise efficient

Язык: Английский

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Multifunctional nanoparticle for cancer therapy

MedComm, Год журнала: 2023, Номер 4(1)

Опубликована: Янв. 11, 2023

Cancer is a complex disease associated with combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment diagnosis for cancer, current strategies simultaneously focus on various tumor targets. Based the rapid development nanotechnology, nanocarriers have been shown to exhibit excellent potential cancer therapy. Compared nanoparticles single functions, multifunctional are believed be more aggressive potent context targeting. However, not simply an upgraded version original function, but involves sophisticated system proper backbone, optimized modification sites, simple preparation method, efficient function integration. Despite this, many well-designed promising therapeutic emerged recently. Here, give detailed understanding analyzation currently developed nanoparticles, their platform structures organic or inorganic backbones were systemically generalized. We emphasized functionalization strategies, which additional functions nanoparticle. also discussed application that involved nanoformulations functional crosstalk. This review thus provides overview construction advances nanoparticles.

Язык: Английский

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Doxorubicin-Fe(III)-Gossypol Infinite Coordination Polymer@PDA:CuO₂ Composite Nanoparticles for Cost-Effective Programmed Photothermal-Chemodynamic-Coordinated Dual Drug Chemotherapy Trimodal Synergistic Tumor Therapy

ACS Nano, Год журнала: 2023, Номер 17(13), С. 12544 - 12562

Опубликована: Июнь 24, 2023

To achieve the maximum therapeutic effects and minimize adverse of trimodal synergistic tumor therapies, a cost-effective programmed photothermal (PTT)-chemodynamic (CDT)-coordinated dual drug chemotherapy (CT) therapy strategy in chronological order is proposed. According to status or volumes tumors, intensity time each modality are optimized, three modalities combined programmatically work order. The optimal begins with high-intensity PTT for 10 min ablate larger followed by medium-intensity CDT several hours eliminate medium-sized then low-intensity coordinated drugs CT lasts over 48 h clear smaller residual tumors. Composite nanoparticles, made Fe-coordinated polydopamine mixed copper peroxide as cores their surface dotted lots doxorubicin-Fe(III)-gossypol infinite coordination polymers (ICPs), have been developed implement strategy. These composite nanoparticles show excellent minimum dose agents result nearly 100% inhibition mice bearing PC-3 tumors no observed recurrence within 60 days treatment. ratios different can be adjusted accommodate types this

Язык: Английский

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Glucose-Responsive hydrogel optimizing Fenton reaction to eradicate multidrug-resistant bacteria for infected diabetic wound healing

Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150545 - 150545

Опубликована: Март 19, 2024

Язык: Английский

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Research progress of organic photothermal agents delivery and synergistic therapy systems

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 234, С. 113743 - 113743

Опубликована: Янв. 5, 2024

Язык: Английский

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