ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 30, 2025
Various
smart
scaffolds
have
recently
been
developed
to
address
the
regeneration
of
tumor
bone
defect.
However,
recurrence
residual
cells
poses
a
serious
challenge
postoperative
management,
highlighting
need
for
effective
therapeutic
interventions.
In
this
study,
multifunctional
antitumor
nanoplatform
(Ti3C2/CuO2)
synergistic
chemo-sonodynamic
therapy
was
and
then
rationally
integrated
into
poly(l-lactic
acid)
(PLLA)
scaffold
via
selective
laser
sintering.
CuO2
not
only
releases
Cu2+
ions
facilitate
chemodynamic
through
Fenton
reaction
but
also
generates
H2O2,
which
further
oxidizes
Ti3C2
produce
TiO2
sonosensitizers.
More
importantly,
carbon-based
substrates
after
oxidation
created
favorable
conditions
carrier
transmission
in
sonodynamic
process,
thereby
amplifying
therapy.
Additionally,
moderate
local
hyperthermia
form
periodic
produces
localized
heat
stimulate
tissue
regeneration.
Meanwhile,
sustained
release
bioactive
(such
as
Cu
Ti
ions)
from
fosters
vascularization,
accelerating
This
work
presents
viable
approach
developing
repairing
tumorous
defects.
Copper
(Cu),
a
crucial
trace
element
in
physiological
processes,
has
garnered
significant
interest
for
its
involvement
cancer
progression
and
potential
therapeutic
applications.
The
regulation
of
cellular
copper
levels
is
essential
maintaining
homeostasis,
as
imbalances
can
lead
to
toxicity
cell
death.
development
drugs
that
target
homeostasis
emerged
promising
strategy
anticancer
treatment,
with
particular
focus
on
chelators,
ionophores,
novel
complexes.
Recent
research
also
investigated
the
complexes
therapy.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
265, С. 130960 - 130960
Опубликована: Март 20, 2024
Tumors
remain
one
of
the
major
threats
to
public
health
and
there
is
an
urgent
need
design
new
pharmaceutical
agents
for
their
diagnosis
treatment.
In
recent
years,
due
rapid
development
nanotechnology,
biotechnology,
catalytic
science,
theoretical
computing,
subtlety
has
gradually
made
great
progress
in
research
related
tumor
Compared
conventional
drugs,
enzymes
can
improve
drug
distribution
enhance
enrichment
at
site,
thereby
reducing
side
effects
enhancing
efficacy.
Nanozymes
also
be
used
as
tracking
imaging
reshape
microenvironment,
providing
a
versatile
platform
treatment
malignancies.
this
paper,
we
review
current
status
on
oncology
analyze
novel
therapeutic
approaches
mechanisms.
To
date,
large
number
nanomaterials,
such
noble
metal
nonmetallic
carbon-based
have
been
shown
able
function
like
natural
enzymes,
particularly
with
significant
advantages
therapy.
light
this,
authors
systematically
summarized
evaluated
construction,
enzymatic
activity,
characteristics
nanozymes
respect
modalities
addition,
application
different
types
nicknames
features
years
are
detail.
We
conclude
summary
outlook
study
It
hoped
that
will
inspire
researchers
fields
chemistry,
biology,
materials
science
contribute
nano-enzymology.
ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
10(6), С. 3673 - 3692
Опубликована: Май 8, 2024
Copper
(Cu)
and
Cu-based
nanomaterials
have
received
tremendous
attention
in
recent
years
because
of
their
unique
physicochemical
properties
good
biocompatibility
the
treatment
various
diseases,
especially
cancer.
To
date,
researchers
designed
fabricated
a
variety
integrated
nanocomplexes
with
distinctive
nanostructures
applied
them
cancer
therapy,
mainly
including
chemotherapy,
radiotherapy
(RT),
photothermal
therapy
(PTT),
chemodynamic
(CDT),
photodynamic
(PDT),
cuproptosis-mediated
etc.
Due
to
limited
effect
single
method,
development
composite
diagnostic
nanosystems
that
integrate
PTT,
CDT,
PDT,
other
treatments
is
great
significance
offers
potential
for
next
generation
anticancer
nanomedicines.
In
view
rapid
field
this
review
focuses
on
current
state
research
nanomaterials,
followed
by
discussion
combined
therapy.
Moreover,
challenges
future
prospects
clinical
translation
are
proposed
provide
some
insights
into
design
nanotherapeutic
platforms.
Abstract
Chemodynamic
therapy
(CDT)
has
shown
promising
antitumor
effects
in
various
malignant
tumors.
However,
its
application
for
glioblastoma
(GBM)
is
significantly
hindered
by
the
challenge
of
delivering
CDT
agents
across
blood‐brain
barrier
(BBB)
and
achieving
efficient
tumor
targeting.
To
overcome
these
obstacles,
this
study
presents
a
novel
DNA
nanomachine
(Cu@tFNAs‐G‐A
NM)
loading
copper
ions
(Cu
2+
)
onto
tetrahedral
framework
nucleic
acids
(tFNAs)
functionalized
with
dual
aptamers.
The
aptamers
(GS24
BBB
penetration
AS1411
targeting)
empowered
Cu@tFNAs‐G‐A
NM
ability
to
effectively
penetrate
selectively
accumulate
cells.
Upon
internalization,
loaded
Cu
reacted
tumor‐overexpressed
reductive
glutathione
(GSH)
hydrogen
peroxide
(H
2
O
),
generating
hydroxyl
radicals
(·OH)
inducing
cell
death.
Additionally,
was
found
be
rapidly
cleared
from
brain
normal
tissues
within
24
h,
minimizing
potential
systemic
toxic
side
effects.
These
findings
demonstrate
effective
against
GBM
open
up
new
avenues
development
targeted
therapies
GBM.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 26, 2024
Abstract
Background
Hypoxia-activated
prodrugs
present
new
opportunities
for
safe
and
effective
tumor
drug
resistance
therapy
due
to
their
high
selectivity
hypoxic
cells.
However,
the
uneven
distribution
of
oxygen
in
solid
insufficient
hypoxia
microenvironment
greatly
limit
its
therapeutic
efficacy.
Results
In
this
paper,
a
novel
AQ4N-Mn(II)@PDA
coordination
nanoplatform
was
designed
functionalized
with
GMBP1
target
drug-resistant
Its
excellent
photothermal
conversion
efficiency
could
achieve
local
high-temperature
tumors,
which
not
only
effectively
exacerbate
thus
improve
efficacy
hypoxia-activated
chemotherapy
AQ4N
but
also
significantly
accelerate
Mn
2+
-mediated
Fenton-like
activity
enhance
chemodynamic
therapy.
Moreover,
real-time
monitoring
blood
saturation
through
photoacoustic
imaging
reflect
status
tumors
during
treatment.
Furthermore,
synergistic
treatment
inhibited
growth
improved
survival
rate
mice
bearing
orthotopic
tumors.
Conclusions
This
study
provided
idea
PTT
combined
CDT
explored
vital
theory
