Advanced Materials,
Год журнала:
2023,
Номер
35(24)
Опубликована: Март 5, 2023
Allosteric
transitions
can
modulate
the
self-assembly
and
biological
function
of
proteins.
It
remains,
however,
tremendously
challenging
to
design
synthetic
allosteric
polymeric
assemblies
with
spatiotemporally
switchable
hierarchical
structures
functionalities.
Here,
a
photoallosteric
polymersome
is
constructed
that
undergoes
rapid
conformational
transition
from
β-sheet
α-helix
upon
exposure
near-infrared
light
irradiation.
In
addition
improving
nanoparticle
cell
penetration
lysosome
escape,
photoinduced
behavior
reconstructs
vesicular
membrane
structure,
which
stimulates
release
hydrophilic
cytolytic
peptide
melittin
hydrophobic
kinase
inhibitor
sorafenib.
Combining
on-demand
delivery
multiple
therapeutics
phototherapy
results
in
apoptosis
immunogenic
death
tumor
cells,
remold
immune
microenvironment
achieve
an
excellent
synergistic
anticancer
efficacy
vivo
without
recurrence
metastasis.
Such
light-modulated
non-photosensitive
polymers
provides
new
insight
into
development
smart
nanomaterials
for
biosensing
drug
applications.
Advanced Materials,
Год журнала:
2023,
Номер
36(10)
Опубликована: Фев. 16, 2023
Abstract
The
growing
interest
in
nanomedicine
over
the
last
20
years
has
carved
out
a
research
field
called
“nanocatalytic
therapy,”
where
catalytic
reactions
mediated
by
nanomaterials
are
employed
to
intervene
disease‐critical
biomolecular
processes.
Among
many
kinds
of
catalytic/enzyme‐mimetic
investigated
thus
far,
ceria
nanoparticles
stand
from
others
owing
their
unique
scavenging
properties
against
biologically
noxious
free
radicals,
including
reactive
oxygen
species
(ROS)
and
nitrogen
(RNS),
exerting
enzyme
mimicry
nonenzymatic
activities.
Much
effort
been
made
utilize
as
self‐regenerating
antioxidative
anti‐inflammatory
agents
for
various
diseases,
given
detrimental
effects
ROS
RNS
therein
that
need
alleviation.
In
this
context,
review
is
intended
provide
an
overview
what
makes
merit
attention
disease
therapy.
introductory
part
describes
characteristics
oxygen‐deficient
metal
oxide.
pathophysiological
roles
then
presented,
well
mechanisms
nanoparticles.
Representative
examples
recent
ceria‐nanoparticle‐based
therapeutics
summarized
categorization
into
organ
types,
followed
discussion
on
remaining
challenges
future
directions.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(22), С. 7707 - 7736
Опубликована: Янв. 1, 2023
This
review
summarizes
the
strategies
to
engineer
CDT
nanocatalysts
based
on
diverse
nanocarriers,
especially
those
with
intrinsic
therapeutic
activities.
Cancer
is
a
complex
disease
associated
with
combination
of
abnormal
physiological
process
and
exhibiting
dysfunctions
in
multiple
systems.
To
provide
effective
treatment
diagnosis
for
cancer,
current
strategies
simultaneously
focus
on
various
tumor
targets.
Based
the
rapid
development
nanotechnology,
nanocarriers
have
been
shown
to
exhibit
excellent
potential
cancer
therapy.
Compared
nanoparticles
single
functions,
multifunctional
are
believed
be
more
aggressive
potent
context
targeting.
However,
not
simply
an
upgraded
version
original
function,
but
involves
sophisticated
system
proper
backbone,
optimized
modification
sites,
simple
preparation
method,
efficient
function
integration.
Despite
this,
many
well-designed
promising
therapeutic
emerged
recently.
Here,
give
detailed
understanding
analyzation
currently
developed
nanoparticles,
their
platform
structures
organic
or
inorganic
backbones
were
systemically
generalized.
We
emphasized
functionalization
strategies,
which
additional
functions
nanoparticle.
also
discussed
application
that
involved
nanoformulations
functional
crosstalk.
This
review
thus
provides
overview
construction
advances
nanoparticles.
ACS Nano,
Год журнала:
2023,
Номер
17(13), С. 12544 - 12562
Опубликована: Июнь 24, 2023
To
achieve
the
maximum
therapeutic
effects
and
minimize
adverse
of
trimodal
synergistic
tumor
therapies,
a
cost-effective
programmed
photothermal
(PTT)-chemodynamic
(CDT)-coordinated
dual
drug
chemotherapy
(CT)
therapy
strategy
in
chronological
order
is
proposed.
According
to
status
or
volumes
tumors,
intensity
time
each
modality
are
optimized,
three
modalities
combined
programmatically
work
order.
The
optimal
begins
with
high-intensity
PTT
for
10
min
ablate
larger
followed
by
medium-intensity
CDT
several
hours
eliminate
medium-sized
then
low-intensity
coordinated
drugs
CT
lasts
over
48
h
clear
smaller
residual
tumors.
Composite
nanoparticles,
made
Fe-coordinated
polydopamine
mixed
copper
peroxide
as
cores
their
surface
dotted
lots
doxorubicin-Fe(III)-gossypol
infinite
coordination
polymers
(ICPs),
have
been
developed
implement
strategy.
These
composite
nanoparticles
show
excellent
minimum
dose
agents
result
nearly
100%
inhibition
mice
bearing
PC-3
tumors
no
observed
recurrence
within
60
days
treatment.
ratios
different
can
be
adjusted
accommodate
types
this
Advanced Materials,
Год журнала:
2023,
Номер
35(51)
Опубликована: Май 5, 2023
Abstract
Recently,
2D
transition
metal
carbide,
nitride,
and
carbonitrides
(MXenes)
materials
stand
out
in
the
field
of
tumor
therapy,
particularly
construction
functional
platforms
for
optimal
antitumor
therapy
due
to
their
high
specific
surface
area,
tunable
performance,
strong
absorption
near‐infrared
light
as
well
preferable
plasmon
resonance
effect.
In
this
review,
progress
MXene‐mediated
is
summarized
after
appropriate
modifications
or
integration
procedures.
The
enhanced
treatments
directly
performed
by
MXenes,
significant
improving
effect
MXenes
on
different
therapies,
imaging‐guided
strategies
are
discussed
detail.
Moreover,
existing
challenges
future
development
directions
presented.
