Advanced Materials,
Год журнала:
2023,
Номер
35(24)
Опубликована: Март 5, 2023
Allosteric
transitions
can
modulate
the
self-assembly
and
biological
function
of
proteins.
It
remains,
however,
tremendously
challenging
to
design
synthetic
allosteric
polymeric
assemblies
with
spatiotemporally
switchable
hierarchical
structures
functionalities.
Here,
a
photoallosteric
polymersome
is
constructed
that
undergoes
rapid
conformational
transition
from
β-sheet
α-helix
upon
exposure
near-infrared
light
irradiation.
In
addition
improving
nanoparticle
cell
penetration
lysosome
escape,
photoinduced
behavior
reconstructs
vesicular
membrane
structure,
which
stimulates
release
hydrophilic
cytolytic
peptide
melittin
hydrophobic
kinase
inhibitor
sorafenib.
Combining
on-demand
delivery
multiple
therapeutics
phototherapy
results
in
apoptosis
immunogenic
death
tumor
cells,
remold
immune
microenvironment
achieve
an
excellent
synergistic
anticancer
efficacy
vivo
without
recurrence
metastasis.
Such
light-modulated
non-photosensitive
polymers
provides
new
insight
into
development
smart
nanomaterials
for
biosensing
drug
applications.
Abstract
Glutathione
(GSH)
is
the
primary
antioxidant
in
cells,
and
GSH
consumption
will
break
redox
balance
cells.
Based
on
this,
a
method
that
uses
high
concentrations
of
tumor
microenvironment
to
trigger
reaction
Cu(II)
generate
copper
nanoprobes
with
fluorescence
growth
inhibition
properties
proposed.
The
nanoprobe
mainly
exists
form
Cu(I)
catalyzes
decomposition
hydrogen
peroxide
into
hydroxyl
radicals.
At
same
time,
simple
controllable
carbon
micro‐nano
electrode
used
construct
single‐cell
sensing
platform,
which
enable
detection
glutathione
content
single
living
cells
after
treatment,
providing
an
excellent
example
for
detecting
biomolecules.
Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(43), С. 19884 - 19895
Опубликована: Окт. 2, 2022
Abnormal
metabolic
symbiosis
is
a
typical
characteristic
that
differentiates
the
tumor
regions
from
healthy
tissues
and
meanwhile
maintains
survival.
It
of
great
potential
to
disrupt
intratumoral
in
therapy.
Herein,
we
report
specific
therapy
strategy
through
inducing
acidosis
for
elimination,
which
based
on
carbonic
anhydrase
inhibitor
(CAI)-modified
ferrous
sulfide
nanoparticles
(FeS-PEG-CAI
NPs).
The
FeS-PEG-CAI
NPs
show
acid-responsive
degradation
capacity
release
functional
components,
including
CAI,
Fe2+,
H2S,
while
remaining
quite
stable
under
normal
physiological
conditions.
generated
CAI
H2S
gas
can
not
only
intracellular
induce
but
also
provide
suitable
circumstances
Fe2+-mediated
Fenton
reaction,
producing
abundant
toxic
hydroxyl
radicals.
Meanwhile,
these
dual-mode
imaging
with
photoacoustic
magnetic
resonance
imaging,
dynamically
monitor
location
process
synergistic
chemodynamic/photothermal/gas
Overall,
developed
exert
their
role
disrupting
other
effects,
further
enrich
treatment
strategies.
ACS Nano,
Год журнала:
2023,
Номер
17(12), С. 11290 - 11308
Опубликована: Июнь 5, 2023
Cancer
phototheranostics
have
the
potential
for
significantly
improving
therapeutic
effectiveness,
as
it
can
accurately
diagnose
and
treat
cancer.
However,
current
phototheranostic
platforms
leave
much
to
be
desired
are
often
limited
by
tumor
hypoxia.
Herein,
a
Schottky
junction
nanozyme
has
been
established
between
manganese-bridged
cobalt-phthalocyanines
complex
Ti3C2Tx
MXene
nanosheets
(CoPc-Mn/Ti3C2Tx),
which
serve
an
integrative
type
I
II
photosensitizer
enhancing
cancer
efficacy
via
photoacoustic
imaging-guided
multimodal
chemodynamic/photothermal/photodynamic
therapy
strategy
under
near-infrared
(808
nm)
light
irradiation.
The
not
only
possessed
narrow-bandgap,
enhanced
electron-hole
separation
ability
exhibited
potent
redox
but
also
enabled
improved
H2O2
O2
supplying
performances
in
vitro.
Accordingly,
AS1411
aptamer-immobilized
CoPc-Mn/Ti3C2Tx
illustrated
high
accuracy
excellent
anticancer
efficiency
through
vitro
vivo
experiments.
This
work
presents
valuable
method
designing
constructing
multifunctional
nanocatalytic
medicine
platform
synergistic
of
solid
tumors.
Cascade
hydroxyl
radical
generating
hydrogel
reactor
structures
including
a
chemotherapeutic
agent
are
invented
for
multiple
treatment
of
breast
cancer.
Glucose
oxidase
(GOx)
and
cupric
sulfate
(Cu)
introduced
transforming
accumulated
glucose
(in
cancer
cells)
to
radicals
starvation/chemodynamic
therapy.
Cu
may
also
suppress
cell
growth
via
cuproptosis-mediated
death.
Berberine
hydrochloride
(BER)
is
engaged
as
in
the
combining
with
starvation/chemodynamic/cuproptosis
therapeutic
modalities.
Moreover,
participated
gel
crosslinker
by
coordinating
catechol
groups
hyaluronic
acid-dopamine
(HD)
polymer.
Controlling
viscoelasticity
can
extend
retention
time
following
local
injection
provide
sustained
drug
release
patterns.
Low
biodegradation
rate
designed
HD/BER/GOx/Cu
reduce
dosing
frequency
therapy
avoid
invasiveness-related
inconveniences.
Especially,
it
anticipated
that
system
be
applied
reducing
size
prior
surgery
well
tumor
suppression
clinical
application.
The
wide
and
frequent
use
of
antibiotics
in
the
treatment
bacterial
infection
can
cause
occurrence
multidrug-resistant
bacteria,
which
becomes
a
serious
health
threat.
Therefore,
it
is
necessary
to
develop
antibiotic-independent
modalities.
Chemodynamic
therapy
(CDT)
defined
as
approach
employing
Fenton
and/or
Fenton-like
reactions
for
generating
hydroxyl
radical
(•OH)
that
kill
target
cells.
Recently,
CDT
has
been
successfully
employed
antibacterial
applications.
Apart
from
common
Fe-mediated
strategy,
strategies
mediated
by
other
metal
elements
such
copper,
manganese,
cobalt,
molybdenum,
platinum,
tungsten,
nickel,
silver,
ruthenium,
zinc
have
also
proposed.
Furthermore,
different
types
materials
like
nanomaterials
hydrogels
be
adopted
constructing
CDT-involved
platforms.
Besides,
introduce
some
toxic
then
achieve
synergistic
effects
together
with
reactive
oxygen
species.
Finally,
combined
therapies
starvation
therapy,
phototherapy,
sonodynamic
achieving
improved
performance.
This
review
first
summarizes
advancements
discusses
present
limitations
future
research
directions
this
field,
hoping
promote
development
more
effective
potentiated
CDT.
