Applications and Prospects of Micro/nanoelectrodes in Single-cell Imaging and Electrochemical Detection

TrAC Trends in Analytical Chemistry, Год журнала: 2025, Номер unknown, С. 118161 - 118161

Опубликована: Янв. 1, 2025

Язык: Английский

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Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Abstract Designing drugs to intelligently respond different ratio of biological electron donors/receptors in cancer cells and normal is a promising strategy achieve highly effective less toxic chemotherapy. Herein by employing metal center active the selenium‐containing electrophilic drug Ru(phtpy‐NO 2 )(phenSe)Cl ( RuSe ) with strongly polarization characteristics are synthesized which can efficiently shuttle electrons from donors convert oxidative stress. The rate transfer at selenium 1.81 times higher cell environments compared environments. This results being 14.98 more lethal than cells. Experimental demonstrate that transport process carried out via radicals intermediate positively correlated properties atoms. transports bioactive generate large number superoxide anions leading DNA damage decrease mitochondrial membrane potential further activates p53 signaling pathway amplifies cell‐killing effect after transporting electrons. work provides new avenue for design efficient chemotherapeutic agents.

Язык: Английский

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Versatile Nanomaterials That Interfere with Ferroptosis in the Tumor Microenvironment

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 2461 - 2473

Опубликована: Фев. 1, 2025

Ferroptosis is a type of iron-dependent programmed cell death characterized by depletion glutathione. Although generally less harmful to normal cells, in tumor the high demand for iron ions provides conditions conducive ferroptosis. In this review, we provide an overview recent progress research on regulation ferroptosis summarizing and assessing current state, trends, applications nanomaterials cells. Given advantages terms targeting, safety, improved drug efficacy, reduced side effects, these materials are considered have potential therapeutic value modulating cells via different mechanisms. respect, describe methods modifying interfering with glutathione activity lipid peroxidation. The development that can be applied induce or inhibit anticipated new options treatment diverse range diseases.

Язык: Английский

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Intelligent responsive nanogels: New Horizons in cancer therapy

International Journal of Pharmaceutics, Год журнала: 2024, Номер 669, С. 125050 - 125050

Опубликована: Дек. 5, 2024

Язык: Английский

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Homogeneous electrochemiluminescence sensor based on novel Ru-MOF nanosheets for highly sensitive and efficient detection of glutathione without immobilization

Microchimica Acta, Год журнала: 2025, Номер 192(5)

Опубликована: Апрель 12, 2025

Язык: Английский

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A CuS/Ag/Pt@ICG/DOX nanoplatform with cascaded nanozyme catalysis for tumor microenvironment remodeling and synergistic photodynamic/photothermal/chemodynamic therapy

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 253, С. 114743 - 114743

Опубликована: Апрель 29, 2025

Язык: Английский

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A bifunctional drug delivery system with targeting and glutathione-responsivity amphiphiles for effective tumor therapy

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 107041 - 107041

Опубликована: Май 1, 2025

Язык: Английский

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Glutathione: A Naturally-occurring Tripeptide for Functional Metal Nanomaterials

Chemical Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Glutathione's role in synthesizing functional metal nanomaterials with unique optical properties and nanobiomedical applications.

Язык: Английский

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Tumor Microenvironment-Responsive Lipid Peroxidation Amplifier: Harnessing Ferroptosis Resistance to Devastate the Ferroptosis Defense System

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Amplification of lipid peroxidation with tumor specificity represents a new avenue to boost ferroptosis-mediated anticancer therapeutics but remains challenging. Herein, we proposed metal-phenolic-network (MPN)-coated nanohybrid as microenvironment-responsive amplifier, consisting reactive oxygen species generator MPN, glutathione (GSH) scavenger GSH-P, and peroxidase 4 (GPX4) mRNA gene silencing sequence. The protective MPN shell this amplifier can be specifically disintegrated by acidic adenosine triphosphate (ATP)-rich microenvironments induce oxidative stress through the dual disruption redox homeostasis (Fenton-catalytic accumulation GSH depletion). Furthermore, stress-induced upregulation ferroptosis resistance-related apurinic/apyrimidinic endonuclease 1 (APE1) is further ingeniously employed an amplification element prompt release (AP) site-embedded GPX4 sequence which downregulate level. Based on tandem depletion substrate GPX4, defense system GPX4/GSH heavily devastated enable for effectively improving efficiency. We expect strategy expanded other important regulatory proteins provide mechanism study therapy.

Язык: Английский

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Application of zeolitic imidazolate frameworks-8 in drug delivery and disease therapy: A review

Inorganic Chemistry Communications, Год журнала: 2024, Номер unknown, С. 113835 - 113835

Опубликована: Дек. 1, 2024

Язык: Английский

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