Inorganic Chemistry Communications, Год журнала: 2024, Номер 170, С. 113214 - 113214
Опубликована: Сен. 23, 2024
Язык: Английский
Advanced Science, Год журнала: 2023, Номер 10(18)
Опубликована: Апрель 23, 2023
Dendritic cell (DC)-based cancer immunotherapy has exhibited remarkable clinical prospects because DCs play a central role in initiating and regulating adaptive immune responses. However, the application of traditional DC-mediated is limited due to insufficient antigen delivery, inadequate presentation, high levels immunosuppression. To address these challenges, engineered biomaterials have been exploited enhance immunotherapeutic effects. In this review, vital principal components that can effects are first introduced. The parameters considered rational design biomaterials, including targeting modifications, size, shape, surface, mechanical properties, which affect biomaterial optimization DC functions, further summarized. Moreover, recent applications various field reviewed, those serve as component delivery platforms, remodel tumor microenvironment, synergistically other antitumor therapies. Overall, present review comprehensively systematically summarizes related promotion functions; specifically focuses on advances designs for activation eradicate tumors. challenges opportunities treatment strategies designed amplify via discussed with aim inspiring translation future immunotherapies.
Язык: Английский
Процитировано
51
Advanced Functional Materials, Год журнала: 2024, Номер 34(44)
Опубликована: Май 20, 2024
Abstract Mild photothermal therapy (PTT) is an emerging and elegant approach with minimal adverse effects, demonstrating itself as effective treatment for cancer. However, potential challenges may arise from the overexpression of heat shock protein 90 (HSP90) reliance on monotherapy. Here, a near‐infrared (NIR) light‐triggered MXene nanocomposite (FA@MXene/CuO 2 /GA) developed to synergistically combine mild PTT chemodynamic (CDT) remarkably tumor eradication without any notable tissue damage. Under irradiation NIR light, effectively enhances by suppressing HSP90 expression through release gambogic acid (GA) due excellent performance Ti 3 C nanosheets well tumor‐targeting ability biocompatibility surface‐modified FA‐PEG‐SH. The copper‐based catalyst CuO in this system releases Cu 2+ acid‐triggered manner within microenvironment, activating Fenton‐like reaction generate hydroxyl radicals, simultaneous production H O serves alleviate deficiency endogenous tumor. Overall, current work showcases remarkable synergistic anticancer effect CDT, also proposes new avenues research utilizing nanomaterials treatment.
Язык: Английский
Процитировано
25
Molecular Cancer, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 18, 2025
Clinically, multimodal therapies are adopted worldwide for the management of cancer, which continues to be a leading cause death. In recent years, immunotherapy has firmly established itself as new paradigm in cancer care that activates body's immune defense cope with cancer. Immunotherapy resulted significant breakthroughs treatment stubborn tumors, dramatically improving clinical outcome patients. Multiple forms immunotherapy, including checkpoint inhibitors (ICIs), adoptive cell therapy and vaccines, have become widely available. However, effectiveness these immunotherapies is not much satisfying. Many patients do respond disease recurrence appears unavoidable because rapidly evolving resistance. Moreover, can give rise severe off-target immune-related adverse events. Strategies remove hindrances mainly focus on development combinatorial or exploitation novel immunotherapeutic mediations. Nanomaterials carrying anticancer agents target site considered practical approaches treatment. Nanomedicine combined offers possibility potentiate systemic antitumor immunity facilitate selective cytotoxicity against cells an effective safe manner. A myriad nano-enabled currently under investigation. Owing gaps between preclinical studies, nano-immunotherapy faces multiple challenges, biosafety nanomaterials trial design. this review, we provide overview summarize evidence indicating how nanomedicine-based increase efficacy immunotherapies. We also discuss key challenges emerged era nanotechnology-based immunotherapy. Taken together, combination drawing increasing attention, it anticipated will achieve desired success therapy.
Язык: Английский
Процитировано
15
Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)
Опубликована: Июль 23, 2023
Abstract Therapeutic tumor vaccines have attracted considerable attention in the past decade; they can induce regression, eradicate minimal residual disease, establish lasting immune memory and avoid non-specific adverse side effects. However, challenge field of therapeutic is ensuring delivery components to lymph nodes (LNs) activate cells. The clinical response rate traditional falls short expectations due inadequate node delivery. With rapid development nanotechnology, a large number nanoplatform-based LN-targeting nanovaccines been exploited for optimizing immunotherapies. In addition, some possess non-invasive visualization performance, which benefit understanding kinetics nanovaccine exposure LNs. Herein, we present parameters nanoplatforms, such as size, surface modification, shape, deformability, affect functions nanovaccines. recent advances nanoplatforms with different promoting are also summarized. Furthermore, emerging LNs-targeting nanoplatform-mediated imaging strategies both improve targeting performance enhance quality LN discussed. Finally, summarize prospects challenges /or strategies, optimize efficacy
Язык: Английский
Процитировано
34
Advanced Healthcare Materials, Год журнала: 2023, Номер 12(17)
Опубликована: Фев. 19, 2023
Traditional dendritic cell (DC)-mediated immunotherapy is usually suppressed by weak immunogenicity in tumors and generally leads to unsatisfactory outcomes. Synergistic exogenous/endogenous immunogenic activation can provide an alternative strategy for evoking a robust immune response promoting DC activation. Herein, Ti
Язык: Английский
Процитировано
25
International Immunopharmacology, Год журнала: 2024, Номер 128, С. 111548 - 111548
Опубликована: Янв. 19, 2024
Язык: Английский
Процитировано
15
BMEMat, Год журнала: 2024, Номер 2(2)
Опубликована: Янв. 10, 2024
Abstract Two‐dimensional (2D) nanomaterials, known for their unique atomic arrangements and exceptional physicochemical properties, have garnered significant attention in biomedical applications, particularly the realms of immunotherapy tissue engineering tumor therapy. These applications necessitate a thorough assessment potential influence 2D nanomaterials on immune cells. Notably, mononuclear phagocyte system (MPS) cells, which play pivotal roles both innate adaptive immunity, are essential maintaining organismal homeostasis. MPS cells with phagocytic capability contribute to prevention foreign body invasion elimination dead or senescent Furthermore, including macrophages dendritic serve as vital bridges between responses. Therefore, understanding nano‐bio interactions is imperative. cellular uptake, cytocompatibility, immunological impact invaluable purposeful design nanomaterials. Herein, we provide an overview latest advancements discuss current challenges future prospects employing field nanomedicine.
Язык: Английский
Процитировано
14
Nano TransMed, Год журнала: 2024, Номер 3, С. 100045 - 100045
Опубликована: Авг. 24, 2024
Язык: Английский
Процитировано
11
Chemical Engineering Journal, Год журнала: 2025, Номер 505, С. 159311 - 159311
Опубликована: Янв. 6, 2025
Язык: Английский
Процитировано
2
Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 184, С. 117897 - 117897
Опубликована: Фев. 7, 2025
Язык: Английский
Процитировано
2