Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 5, 2024
Abstract
Nanomedicine
has
shown
great
anticancer
potential
by
disrupting
redox
homeostasis
and
increasing
the
levels
of
oxidative
stress,
but
therapeutic
effect
is
limited
factors
including
intrinsic
self‐protection
mechanism
tumors.
Cancer
cell
death
can
be
induced
exploration
different
mechanisms,
such
as
apoptosis,
pyroptosis,
necroptosis,
cuproptosis,
ferroptosis.
The
merging
nanotechnology
with
biomedicine
provided
tremendous
opportunities
to
construct
death‐based
nanomedicine
for
innovative
cancer
therapy.
Nanocarriers
are
not
only
used
targeted
delivery
inducers,
also
components
induce
achieve
efficient
tumor
treatment.
This
review
focuses
on
seven
modalities
mediated
nanomaterials,
ferroptosis,
cuprotosis,
immunogenic
death,
autophagy.
mechanisms
these
described
in
detail,
well
preparation
nanomaterials
that
them
they
exert
their
effects.
Finally,
this
work
describes
future
development
based
current
knowledge
related
nanomaterials.
Ferroptosis
is
a
distinct
form
of
iron-dependent
programmed
cell
death
characterized
primarily
by
intracellular
iron
accumulation
and
lipid
peroxidation.
Multiple
cellular
processes,
including
amino
acid
metabolism,
various
signaling
pathways,
autophagy,
have
been
demonstrated
to
influence
the
induction
progression
ferroptosis.
Recent
investigations
elucidated
that
ferroptosis
plays
crucial
role
in
pathogenesis
pulmonary
disorders,
lung
injury,
chronic
obstructive
disease,
fibrosis,
asthma.
increasingly
recognized
as
promising
novel
strategy
for
cancer
treatment.
Various
immune
cells
within
tumor
microenvironment,
CD8+
T
cells,
macrophages,
regulatory
natural
killer
dendritic
shown
induce
modulate
process
through
regulation
metabolism
pathways.
Conversely,
can
reciprocally
alter
metabolic
environment,
leading
activation
or
inhibition
functions,
thereby
modulating
responses.
This
paper
reviews
molecular
mechanism
describes
discusses
connection
between
microenvironment
diseases,
development
prospect
their
interaction
treatment
diseases.
The
design
of
nanozymes
with
controlled
properties
and
well-defined
mechanisms
holds
significant
promise
for
advancing
next-generation
functional
biomaterials
tumor
theranostics.
Here,
we
develop
a
metal-organic
framework
(MOF)-derived
bimetallic
sulfide
nanozyme,
FCS,
ferrotherapy
via
combined
photothermal
catalytic
therapies.
FCS
is
synthesized
by
vulcanizing
the
zeolitic
imidazolate
framework-67
(ZIF-67)
into
cobalt
(Co3S4,
CS),
followed
ferrous
cation
exchange,
resulting
in
enhanced
near-infrared
II
conversion
superior
Fenton-like
activity.
Theoretical
calculations
attribute
these
enhancements
to
Fe
doping,
which
narrows
band
gap,
promotes
electron
transfer
H2O2,
lowers
energy
barrier
active
oxygen
species
generation.
effectively
induces
ferroptosis
through
lipid
peroxidation,
while
supporting
T2-weighted
magnetic
resonance
imaging.
This
study
presents
robust
strategy
MOF
transformation
multifunctional
theranostic
agents,
highlighting
role
metal
ion
doping
optimizing
nanozyme
performance.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 14, 2025
Abstract
Tuning
the
oxidative
stress‐defense
system
plays
a
vital
role
in
treatment
of
breast
tumors.
In
this
study,
pyropheophorbide‐a
(PPa)‐based
prodrug
nanoassembly
is
constructed
by
linking
PPa
with
furoxan,
cysteine‐depleting
nitric
oxide
(NO)
donor,
through
disulfide
bond.
The
as‐prepared
(NOSP)
can
assemble
distearoyl
phosphoethanolamine‐PEG
2000
(DSPE‐PEG
)
to
form
nanoassemblies
aqueous
media.
Following
internalization
tumor
cells,
NOSP
respond
cysteine
(Cys)
and
induce
NO
release
activate
endogenous
matrix
metalloproteinases
(MMP‐1,
‐2),
leading
collagen
degradation
improved
drug
delivery.
addition,
Cys
consumption
impede
biosynthesis
glutathione
(GSH),
while
react
high
levels
intracellular
GSH
within
seconds,
thus
synergizing
photodynamic
therapy
against
tumors
distant
metastasis.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 7367 - 7381
Опубликована: Июль 1, 2024
Chemotherapy
remains
the
primary
therapeutic
approach
for
advanced
Hepatocellular
Carcinoma
(HCC).
The
effect
of
chemotherapy
is
limited
and
toxic
side
effects
are
serious.
aim
this
study
to
develop
a
nanobubble
that
ultrasonically
responsive
reduce
direct
chemotherapy.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 5, 2024
Abstract
Nanomedicine
has
shown
great
anticancer
potential
by
disrupting
redox
homeostasis
and
increasing
the
levels
of
oxidative
stress,
but
therapeutic
effect
is
limited
factors
including
intrinsic
self‐protection
mechanism
tumors.
Cancer
cell
death
can
be
induced
exploration
different
mechanisms,
such
as
apoptosis,
pyroptosis,
necroptosis,
cuproptosis,
ferroptosis.
The
merging
nanotechnology
with
biomedicine
provided
tremendous
opportunities
to
construct
death‐based
nanomedicine
for
innovative
cancer
therapy.
Nanocarriers
are
not
only
used
targeted
delivery
inducers,
also
components
induce
achieve
efficient
tumor
treatment.
This
review
focuses
on
seven
modalities
mediated
nanomaterials,
ferroptosis,
cuprotosis,
immunogenic
death,
autophagy.
mechanisms
these
described
in
detail,
well
preparation
nanomaterials
that
them
they
exert
their
effects.
Finally,
this
work
describes
future
development
based
current
knowledge
related
nanomaterials.
