Advancements in strategies for overcoming the blood–brain barrier to deliver brain-targeted drugs

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Авг. 26, 2024

The blood-brain barrier is known to consist of a variety cells and complex inter-cellular junctions that protect the vulnerable brain from neurotoxic compounds; however, it also complicates pharmacological treatment central nervous system disorders as most drugs are unable penetrate on basis their own structural properties. This dramatically diminished therapeutic effect drug compromised its biosafety. In response, number often delivered lesions in invasive ways bypass obstruction barrier, such subdural administration, intrathecal convection-enhanced delivery. Nevertheless, these intrusive strategies introduce risk injury, limiting clinical application. recent years, intensive development nanomaterials science interdisciplinary convergence medical engineering have brought light penetration for brain-targeted drugs. this paper, we extensively discuss limitations delivery non-invasive nanomedicine disruption. meantime, analyze strengths provide outlooks further systems.

Язык: Английский

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Multifunctional Nanoassembly for MRI-Trackable Dendritic Cell Dependent and Independent Photoimmunotherapy

Nano Letters, Год журнала: 2023, Номер 23(19), С. 9133 - 9142

Опубликована: Сен. 28, 2023

Immunotherapy has emerged as a triumph in the treatment of malignant cancers. Nevertheless, current immunotherapeutics are insufficient addressing tumors characterized by tumor cells' inadequate antigenicity and microenvironment's low immunogenicity (TME). Herein, we developed novel multifunctional nanoassembly termed FMMC through self-assembly indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor 1-methyl-tryptophan prodrug (FM), Ce6, ionic manganese (Mn2+) via noncovalent interactions. The laser-ignited could induce effective immunogenic cell death activate STING/MHC-I signaling pathway, thus deeply sculpting tumor-intrinsic to achieve dendritic (DC)-dependent -independent T responses against tumors. Meanwhile, inhibiting IDO-1, lead immunosuppressive TME reversion an immunoactivated one. FMMC-based phototherapy led up-regulation programmed death-ligand (PD-L1), enhancing sensitivity anti-PD-1 therapy. Furthermore, incorporation Mn2+ into resulted augmented longitudinal relaxivity enhanced MRI for monitoring growth primary lung metastases. Collectively, superior reprogramming performance cells TME, combined with excellent anticancer efficacy capability, made promising immune nanosculptor cancer theranostics.

Язык: Английский

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Rational design of adjuvants boosts cancer vaccines

Progress in molecular biology and translational science, Год журнала: 2024, Номер unknown, С. 101 - 125

Опубликована: Янв. 1, 2024

Язык: Английский

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The cGAS/STING Pathway—A New Potential Biotherapeutic Target for Gastric Cancer?

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(7), С. 736 - 736

Опубликована: Июль 9, 2024

Gastric cancer ranks among the top five deadliest tumors worldwide, both in terms of prevalence and mortality rates. Despite mainstream treatments, efficacy treating gastric remains suboptimal, underscoring urgency for novel therapeutic approaches. The elucidation tumor immunosuppressive microenvironments has shifted focus towards biotherapeutics, which leverage patient’s immune system or biologics to target cells. Biotherapy emerged as a promising alternative resistant traditional chemotherapy, radiation, immunotherapy. Central this paradigm is cGAS-STING pathway, pivotal component innate system. This pathway recognizes aberrant DNA, such that from viral infections cells, triggers an response, thereby reshaping microenvironment into immune-stimulating milieu. In context cancer, harnessing holds significant potential biotherapeutic interventions. review provides comprehensive overview latest research on including insights clinical trials involving STING agonists. Furthermore, it assesses prospects targeting strategy cancer.

Язык: Английский

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Antigen self-presenting dendrosomes swallowing nanovaccines boost antigens and STING agonists codelivery for cancer immunotherapy

Biomaterials, Год журнала: 2024, Номер 316, С. 122998 - 122998

Опубликована: Дек. 9, 2024

Язык: Английский

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