Biomimetic metal-phenolic network with cyclolactam hydrogel coating on PPENK implant facilitate bone repair
Chemical Engineering Journal,
Год журнала:
2024,
Номер
486, С. 150234 - 150234
Опубликована: Март 7, 2024
Язык: Английский
Engineering tunable dual peptide hybrid coatings promote osseointegration of implants
Materials Today Bio,
Год журнала:
2023,
Номер
24, С. 100921 - 100921
Опубликована: Дек. 16, 2023
Utilizing
complementary
bioactive
peptides
is
a
promising
surface
engineering
strategy
for
bone
regeneration
on
osteogenesis.
In
this
study,
we
designed
block
peptides,
(Lysine)
Язык: Английский
Cbfβ: A key regulator in skeletal stem cell differentiation, bone development, and disease
Chenggong Zheng,
Chenyang Zhang,
Y.L. He
и другие.
The FASEB Journal,
Год журнала:
2025,
Номер
39(4)
Опубликована: Фев. 25, 2025
Abstract
The
skeletal
system
comprises
closely
related
yet
functionally
distinct
bone
and
cartilage
tissues,
regulated
by
a
complex
network
of
transcriptional
factors
signaling
molecules.
Among
these,
core‐binding
factor
subunit
beta
(Cbfβ)
emerges
as
critical
co‐transcriptional
that
stabilizes
Runx
proteins,
playing
indispensable
roles
in
development
homeostasis.
Emerging
evidence
from
genetic
mouse
models
has
highlighted
the
essential
role
Cbfβ
directing
lineage
commitment
mesenchymal
stem
cells
(MSCs)
their
differentiation
into
osteoblasts
chondrocytes.
Notably,
deficiency
is
strongly
associated
with
severe
dysplasia,
affecting
both
endochondral
intramembranous
ossification
during
embryonic
postnatal
development.
In
this
review,
we
synthesize
recent
advancements
understanding
structural
molecular
functions
Cbfβ,
particular
focus
on
its
interactions
key
pathways,
including
BMP/TGF‐β,
Wnt/β‐catenin,
Hippo/YAP,
IHH/PTHrP.
These
pathways
converge
Cbfβ/RUNX2
complex,
which
orchestrates
gene
expression
program
for
osteogenesis,
formation,
integration
these
networks
ensures
precise
regulation
development,
remodeling,
repair.
Furthermore,
successful
local
delivery
to
address
abnormalities
underscores
potential
novel
therapeutic
target
disorders
such
cleidocranial
osteoarthritis,
metastases.
By
elucidating
mechanisms
underlying
function
insights
not
only
advance
our
biology
but
also
offer
promising
avenues
clinical
intervention,
ultimately
improving
outcomes
patients
disorders.
Язык: Английский
Targeting TYROBP to influence the immune microenvironment and osteogenic differentiation of mesenchymal stem cells
Journal of Orthopaedic Surgery and Research,
Год журнала:
2025,
Номер
20(1)
Опубликована: Май 28, 2025
Язык: Английский
Enhanced Multi-Enzyme Activity and Bone-Targeted Phosphorus-Doped Carbon Dots for Precise Antioxidant Therapy of Rheumatoid Arthritis
Carbon,
Год журнала:
2025,
Номер
unknown, С. 120514 - 120514
Опубликована: Июнь 1, 2025
Язык: Английский
Sequentially Releasing Aspirin and Osteogenic Growth Peptide Scaffold Modulates Immunity and Bone Homeostasis to Enhance Periodontal Bone Regeneration
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 5, 2025
Язык: Английский
Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration
Advanced Therapeutics,
Год журнала:
2024,
Номер
8(1)
Опубликована: Ноя. 15, 2024
Abstract
Tissue
regeneration
involves
dynamic
dialogue
between
and
among
different
cells
their
surrounding
matrices.
Bone
is
specifically
governed
by
reciprocity
osteoblasts
osteoclasts
within
the
bone
microenvironment.
Osteoclast‐directed
resorption
osteoblast‐directed
formation
of
are
essential
to
remodeling,
crosstalk
these
vital
curating
a
sequence
events
that
culminate
in
creation
tissue.
Among
biomaterial
strategies,
many
have
investigated
use
material
cues
direct
development
activity
osteoblasts.
However,
less
attention
has
been
given
exploring
features
similarly
target
osteoclast
activity,
with
even
fewer
strategies
demonstrating
or
integrating
biomaterial‐directed
modulation
osteoblast‐osteoclast
coupling.
This
review
aims
describe
various
demonstrated
influence
osteoclastogenesis
function,
emphasizing
those
enhance
construct's
ability
achieve
healing
regeneration.
Additionally
discussed
approaches
communication
osteoblasts,
particularly
manner
takes
advantage
Deepening
understanding
how
may
dictate
differentiation,
on
microenvironment
enable
realization
bone‐replacement
interventions
enhanced
integrative
regenerative
capacities.
Язык: Английский
Histatin 1-modified SIS hydrogels enhance the sealing of peri-implant mucosa to prevent peri-implantitis
iScience,
Год журнала:
2023,
Номер
26(11), С. 108212 - 108212
Опубликована: Окт. 14, 2023
Dental
implants
make
it
possible
to
replace
teeth
in
more
sophisticated
ways.
Nevertheless,
peri-implantitis
is
one
of
the
leading
causes
implant
failure,
which
can
be
avoided
with
proper
soft
tissue
sealing.
The
aim
this
study
was
achieve
promotion
synthesis
peri-implant
epithelial
hemidesmosome
through
Histatin
1
and
porcine
small
intestinal
submucosa
(SIS)
hydrogel
form
a
good
seal.
results
show
that
improve
biological
barrier
function
around
by
combining
antibacterial,
promoting
healing
bonding.
This
means
morphology
anti-infection
ability
are
enhanced,
ensures
long-term
stability
implant.SIS-Hst1
has
certain
clinical
application
prevention
early
treatment
peri-implantitis.
In
conclusion,
Hst1-SIS
hydrogel,
as
local
administration
system,
provides
experimental
evidence
for
disease.
Язык: Английский