A prospects tool in virus research: Analyzing the applications of organoids in virus studies DOI
Qi Shen, Yuhan Zhou, Yanqiu Zhou

и другие.

Acta Tropica, Год журнала: 2024, Номер 254, С. 107182 - 107182

Опубликована: Март 11, 2024

Язык: Английский

Organoids as complex (bio)systems DOI Creative Commons
Tiago G. Fernandes

Frontiers in Cell and Developmental Biology, Год журнала: 2023, Номер 11

Опубликована: Авг. 25, 2023

Organoids are three-dimensional structures derived from stem cells that mimic the organization and function of specific organs, making them valuable tools for studying complex systems in biology. This paper explores application theory to understand characterize organoids as exemplars intricate biological systems. By identifying analyzing common design principles observed across diverse natural, technological, social systems, we can gain insights into underlying mechanisms governing organoid behavior function. review outlines general found demonstrates how these manifest within organoids. acknowledging representations illuminate our understanding their normal physiological alterations lead disease. Therefore, incorporating study may foster novel perspectives biology pave way new avenues research therapeutic interventions improve human health wellbeing.

Язык: Английский

Процитировано

7
Recent advances in micro-physiological systems for investigating tumor metastasis and organotropism DOI
Heejeong Yoon, Jonathan Sabaté del Río,

Seung Woo Cho

и другие.

Lab on a Chip, Год журнала: 2024, Номер 24(5), С. 1351 - 1366

Опубликована: Янв. 1, 2024

MPS technology holds great potential for studying complex metastasis organotropism. It effectively simulates the dynamic interactions between distinct organ environments and tumor cells, capturing both their inter- intra-tumor heterogeneity.

Язык: Английский

Процитировано

2
The ethical landscape of human brain organoids and a mindful innovation framework DOI
Nathan A. Shlobin, Julian Savulescu, Matthew L. Baum

и другие.

Nature Reviews Bioengineering, Год журнала: 2024, Номер 2(9), С. 785 - 796

Опубликована: Июль 11, 2024

Язык: Английский

Процитировано

2
Integration of Patient-Derived Organoids and Organ-on-Chip Systems: Investigating Colorectal Cancer Invasion within the Mechanical and GABAergic Tumor Microenvironment DOI Creative Commons
Carly Strelez, Rachel Perez,

John S. Chlystek

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Сен. 17, 2023

Three-dimensional (3D) in vitro models are essential cancer research, but they often neglect physical forces. In our study, we combined patient-derived tumor organoids with a microfluidic organ-on-chip system to investigate colorectal (CRC) invasion the microenvironment (TME). This allowed us create patient-specific and assess impact of forces on biology. Our findings showed that organoid-on-chip more closely resembled patient tumors at transcriptional level, surpassing alone. Using 'omics' methods live-cell imaging, observed heightened responsiveness KRAS mutant TME mechanical These also utilized γ-aminobutyric acid (GABA) neurotransmitter as an energy source, increasing their invasiveness. bioengineered model holds promise for advancing understanding progression improving CRC treatments.

Язык: Английский

Процитировано

5
A prospects tool in virus research: Analyzing the applications of organoids in virus studies DOI
Qi Shen, Yuhan Zhou, Yanqiu Zhou

и другие.

Acta Tropica, Год журнала: 2024, Номер 254, С. 107182 - 107182

Опубликована: Март 11, 2024

Язык: Английский

Процитировано

1