Acta Tropica, Год журнала: 2024, Номер 254, С. 107182 - 107182
Опубликована: Март 11, 2024
Язык: Английский
Acta Tropica, Год журнала: 2024, Номер 254, С. 107182 - 107182
Опубликована: Март 11, 2024
Язык: Английский
Frontiers in Cell and Developmental Biology, Год журнала: 2023, Номер 11
Опубликована: Авг. 25, 2023
Organoids are three-dimensional structures derived from stem cells that mimic the organization and function of specific organs, making them valuable tools for studying complex systems in biology. This paper explores application theory to understand characterize organoids as exemplars intricate biological systems. By identifying analyzing common design principles observed across diverse natural, technological, social systems, we can gain insights into underlying mechanisms governing organoid behavior function. review outlines general found demonstrates how these manifest within organoids. acknowledging representations illuminate our understanding their normal physiological alterations lead disease. Therefore, incorporating study may foster novel perspectives biology pave way new avenues research therapeutic interventions improve human health wellbeing.
Язык: Английский
Процитировано
7Lab on a Chip, Год журнала: 2024, Номер 24(5), С. 1351 - 1366
Опубликована: Янв. 1, 2024
MPS technology holds great potential for studying complex metastasis organotropism. It effectively simulates the dynamic interactions between distinct organ environments and tumor cells, capturing both their inter- intra-tumor heterogeneity.
Язык: Английский
Процитировано
2Nature Reviews Bioengineering, Год журнала: 2024, Номер 2(9), С. 785 - 796
Опубликована: Июль 11, 2024
Язык: Английский
Процитировано
2bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Сен. 17, 2023
Three-dimensional (3D) in vitro models are essential cancer research, but they often neglect physical forces. In our study, we combined patient-derived tumor organoids with a microfluidic organ-on-chip system to investigate colorectal (CRC) invasion the microenvironment (TME). This allowed us create patient-specific and assess impact of forces on biology. Our findings showed that organoid-on-chip more closely resembled patient tumors at transcriptional level, surpassing alone. Using 'omics' methods live-cell imaging, observed heightened responsiveness KRAS mutant TME mechanical These also utilized γ-aminobutyric acid (GABA) neurotransmitter as an energy source, increasing their invasiveness. bioengineered model holds promise for advancing understanding progression improving CRC treatments.
Язык: Английский
Процитировано
5Acta Tropica, Год журнала: 2024, Номер 254, С. 107182 - 107182
Опубликована: Март 11, 2024
Язык: Английский
Процитировано
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