A prospects tool in virus research: Analyzing the applications of organoids in virus studies DOI
Qi Shen, Yuhan Zhou, Yanqiu Zhou

et al.

Acta Tropica, Journal Year: 2024, Volume and Issue: 254, P. 107182 - 107182

Published: March 11, 2024

Language: Английский

Organoids as complex (bio)systems DOI Creative Commons
Tiago G. Fernandes

Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11

Published: Aug. 25, 2023

Organoids are three-dimensional structures derived from stem cells that mimic the organization and function of specific organs, making them valuable tools for studying complex systems in biology. This paper explores application theory to understand characterize organoids as exemplars intricate biological systems. By identifying analyzing common design principles observed across diverse natural, technological, social systems, we can gain insights into underlying mechanisms governing organoid behavior function. review outlines general found demonstrates how these manifest within organoids. acknowledging representations illuminate our understanding their normal physiological alterations lead disease. Therefore, incorporating study may foster novel perspectives biology pave way new avenues research therapeutic interventions improve human health wellbeing.

Language: Английский

Citations

7
Recent advances in micro-physiological systems for investigating tumor metastasis and organotropism DOI
Heejeong Yoon, Jonathan Sabaté del Río,

Seung Woo Cho

et al.

Lab on a Chip, Journal Year: 2024, Volume and Issue: 24(5), P. 1351 - 1366

Published: Jan. 1, 2024

MPS technology holds great potential for studying complex metastasis organotropism. It effectively simulates the dynamic interactions between distinct organ environments and tumor cells, capturing both their inter- intra-tumor heterogeneity.

Language: Английский

Citations

2
The ethical landscape of human brain organoids and a mindful innovation framework DOI
Nathan A. Shlobin, Julian Savulescu, Matthew L. Baum

et al.

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(9), P. 785 - 796

Published: July 11, 2024

Language: Английский

Citations

2
Integration of Patient-Derived Organoids and Organ-on-Chip Systems: Investigating Colorectal Cancer Invasion within the Mechanical and GABAergic Tumor Microenvironment DOI Creative Commons
Carly Strelez, Rachel Perez,

John S. Chlystek

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 17, 2023

Three-dimensional (3D) in vitro models are essential cancer research, but they often neglect physical forces. In our study, we combined patient-derived tumor organoids with a microfluidic organ-on-chip system to investigate colorectal (CRC) invasion the microenvironment (TME). This allowed us create patient-specific and assess impact of forces on biology. Our findings showed that organoid-on-chip more closely resembled patient tumors at transcriptional level, surpassing alone. Using 'omics' methods live-cell imaging, observed heightened responsiveness KRAS mutant TME mechanical These also utilized γ-aminobutyric acid (GABA) neurotransmitter as an energy source, increasing their invasiveness. bioengineered model holds promise for advancing understanding progression improving CRC treatments.

Language: Английский

Citations

5
A prospects tool in virus research: Analyzing the applications of organoids in virus studies DOI
Qi Shen, Yuhan Zhou, Yanqiu Zhou

et al.

Acta Tropica, Journal Year: 2024, Volume and Issue: 254, P. 107182 - 107182

Published: March 11, 2024

Language: Английский

Citations

1