Tumor-microenvironment-activatable organic phototheranostic agents for cancer therapy

Coordination Chemistry Reviews, Год журнала: 2024, Номер 509, С. 215786 - 215786

Опубликована: Март 20, 2024

Язык: Английский

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NIR-II Fluorescence Imaging for In Vivo Quantitative Analysis

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(22), С. 28011 - 28028

Опубликована: Май 24, 2024

In vivo real-time qualitative and quantitative analysis is essential for the diagnosis treatment of diseases such as tumors. Near-infrared-II (NIR-II, 1000-1700 nm) bioimaging an emerging visualization modality based on fluorescent materials. The advantages NIR-II region materials in terms reduced photon scattering low tissue autofluorescence enable with high resolution increasing depth penetration, thus have great potential analysis. this review, we first summarize recent advances imaging, including probe selection, strategies, imaging. Then, describe detail representative applications to illustrate how fluorescence imaging has become important tool Finally, future possibilities challenges

Язык: Английский

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Redox-activated photosensitizers for visualizing precise diagnosis and potentiating cancer therapy

Coordination Chemistry Reviews, Год журнала: 2024, Номер 507, С. 215734 - 215734

Опубликована: Март 5, 2024

Язык: Английский

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Mitochondria-Targetable Near-Infrared Fluorescent Probe for Visualization of Hydrogen Peroxide in Lung Injury, Liver Injury, and Tumor Models

Analytical Chemistry, Год журнала: 2024, Номер 96(26), С. 10488 - 10495

Опубликована: Июнь 20, 2024

Hydrogen peroxide (H2O2) overexpressed in mitochondria has been regarded as a key biomarker the pathological processes of various diseases. However, there is currently lack suitable mitochondria-targetable near-infrared (NIR) probes for visualization H2O2 multiple diseases, such PM2.5 exposure-induced lung injury, hepatic ischemia-reperfusion injury (HIRI), nonalcoholic fatty liver (NAFL), fibrosis (HF), and malignant tumor tissues containing clinical cancer patient samples. Herein, we conceived novel NIR fluorescent probe (HCy-H2O2) by introducing pentafluorobenzenesulfonyl sensing unit into hemicyanine platform. HCy-H2O2 exhibits good sensitivity selectivity toward H2O2, accompanied remarkable "turn-on" fluorescence signal at 720 nm. Meanwhile, stable ability permits monitoring up-generated level during mitophagy. Furthermore, using HCy-H2O2, have successfully observed an overproduced mitochondrial ambient HIRI, NAFL, HF models through imaging. Significantly, achieved both tumor-bear mice well surgical specimens patients, making promising tool diagnosis imaging-guided surgery.

Язык: Английский

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Homo‐Dyad with Outer Hydration Layer Approach for Developing NIR‐II Chromophore of High Stability and Water‐Solubility as Injectable and Sprayable Optical Probe

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(19)

Опубликована: Апрель 8, 2024

Dyes with extended conjugate structures are the focus of extensive design and synthesis efforts, aiming to confer unique improved optical electronic properties. Such advancements render these dyes applicable across a wide spectrum uses, ranging from second-window near-infrared (NIR-II) bioimaging organic photovoltaics. Nevertheless, inherent benefits long conjugation often accompanied by persistent challenges like aggregation, fluorescence quenching, absorption blueshift, low stability poor water solubility. Herein, structural strategy termed "homo-dyad outer hydration layer" is introduced address problems, tailored for development imaging probes exhibiting absorption/emission wavelengths. This approach involves bringing two heptamethine cyanines together through flexible linker, forming homo-dyad structure, while strategically attaching four polyethylene glycol (PEG9) chains terminal heterocycles. imparts excellent solubility, biocompatibility, enhanced chemical, photo-, spectral dyes. Utilizing this strategy, biomarker-activatable probe (HD-FL-4PEG9-N) NIR-II fluorescent 3D multispectral optoacoustic tomography developed, its effectiveness in disease visualization. It can not only serve as an injectable acute kidney injury due high but also sprayable bacterial-infected wounds.

Язык: Английский

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NIR-Absorbing Tetraphenylethene-Containing bisBODIPY Nanoplatforms Demonstrate Effective Lysosome-Targeting and Combinational Phototherapy

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(32), С. 41916 - 41926

Опубликована: Июль 31, 2024

Photosensitizer-based phototherapies, including photodynamic therapy (PDT) and photothermal (PTT), offer safe treatment modalities for tumor ablation with spatiotemporal precision. After photons are absorbed, PDT creates localized chemical damage by generating reactive oxygen species (ROS), while PTT induces thermal damage. However, still faces hypoxic challenges, encounters issues related to heat resistance potential overheating. The combination of shows great as an effective anticancer strategy. By targeting lysosomes carefully designed phototherapeutic reagents combined phototherapy, rapid dysfunction cell death in cancer cells can be induced, showing promise treatment. Herein, two α–α-linked bisBODIPYs tetraphenylethene (TPE) moieties synthesized. These TPE-substituted expand the absorption into NIR range (λmaxabs/λmaxem ∼ 740/810 nm) confer aggregation-induced emission (AIE) activity (λmaxem 912 nm). Moreover, these self-assemble surfactant F-127 nanoparticles (NPs), which efficiently generate ROS (1O2 •OH) both solution cellular environments demonstrate superior conversion efficiencies (η 68.3%) along exceptional stability. More importantly, NPs showed lysosomal remarkable murine models, indicating their precision therapy.

Язык: Английский

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Dual-Locked Enzyme-Activatable Fluorescence Probes for Precise Bioimaging

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Real-time visualization of endogenous enzymes not only helps reveal the underlying biological principles but also provides pathological information for cancer/disease diagnosis and even treatment guidance. To this end, enzyme-activatable fluorescence probes are frequently fabricated that turn their signals "on" exclusively at enzyme-rich region, thus enabling noninvasive real-time imaging interest molecular level with superior sensitivity selectivity. However, in a complex context, commonly used single (i.e., single-locked) may suffer from "false positive" healthy tissues be insufficient to accurately indicate occurrence certain diseases. Therefore, dual-locked have been promoted address these issues. Using dual (or an enzyme another stimulus) as "keys", they permit simultaneous detection distinct biomarkers, offering significantly enhanced precision toward events. Considering recent reviews on remain scarce, we provide review. We summarize progress, particularly highlighting breakthroughs last three years, discuss challenges field.

Язык: Английский

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pH-/Viscosity-Activatable NIR Fluorescent Probes via Acceptor Engineering of Hemicyanine Dyes for High-Contrast Bioimaging

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 15, 2025

Real-time monitoring of the lysosomal microenvironment using small-molecule probes is critical for understanding complex interactions between organelles and diseases associated with dysfunction. Most traditional fluorescent-dye-based lysosome rely on protonation nitrogen atom in morpholine unit to visualize by inhibiting photoinduced electron transfer (PET) effect. However, these often face selectivity issues within cellular microenvironment. For instance, classic hemicyanine dyes (HD) show nonspecific fluorescence responses liver due inappropriate pKa value, leading low imaging contrast risk false positives. Herein, a series novel pH/viscosity-activatable, lysosomal-targeted near-infrared (NIR) fluorescent were developed incorporating naphthalimide dye dyes. These exhibit no at physiological pH weak under acidic conditions (key 1), substantial activation triggered abnormal viscosity pathological tissues 2). Notably, NpCy-4 demonstrated superior signal-to-background ratio (SBR) proved effective real-time situ diagnosis acute gastritis.

Язык: Английский

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Logic-gated approach for targeted delivery and site-selective activation of photothermal agents in precision cancer treatment

Chemical Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Logic-gated strategies represent a promising approach to achieving highly selective cancer therapies. In this work, we present LG-AB (Logic-Gated Aza-BODIPY), an OFF-ON photothermal therapy (PTT) agent designed selectively target cells. undergoes red-shift in its maximum absorbance wavelength when activated the tumor microenvironment, enabling molecule precisely generate heat cancerous tissue upon light irradiation. Unlike conventional activatable agents that rely on single biomarker, employs AND logic-gated design, where glucose transporter 1 (GLUT1) overexpression facilitates targeted cellular uptake cells, followed by activation through elevated glutathione (GSH) levels. Beyond demonstrating efficacy human lung and murine breast show effectively attenuates progression heat-induced apoptosis, with minimal off-target effects surrounding tissues. The versatility of strategy is further demonstrated development application LG-CPT Camptothecin), which utilizes same design. Our results enhancing specificity limiting collateral damage can be broadly applied across different therapeutic agents.

Язык: Английский

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Development of small-molecule NIR-II photothermal agents for image-guided tumor therapy

Coordination Chemistry Reviews, Год журнала: 2025, Номер 533, С. 216549 - 216549

Опубликована: Фев. 27, 2025

Язык: Английский

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