Journal of Photochemistry and Photobiology B Biology, Год журнала: 2024, Номер 262, С. 113078 - 113078
Опубликована: Дек. 9, 2024
Язык: Английский
Coordination Chemistry Reviews, Год журнала: 2024, Номер 506, С. 215710 - 215710
Опубликована: Фев. 20, 2024
Язык: Английский
Процитировано
25
Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12
Опубликована: Май 7, 2024
Immunotherapy has emerged as a promising cancer treatment option in recent years. In immune “hot” tumors, characterized by abundant cell infiltration, immunotherapy can improve patients’ prognosis activating the function of cells. By contrast, “cold” tumors are often less sensitive to owing low immunogenicity tumor cells, an inhibitory microenvironment, and series immune-escape mechanisms. Immunogenic death (ICD) is cellular process facilitate transformation eliciting innate adaptive responses through release (or exposure to) damage-related molecular patterns. Accumulating evidence suggests that various traditional therapies induce ICD, including chemotherapy, targeted therapy, radiotherapy, photodynamic therapy. this review, we summarize biological mechanisms hallmarks ICD introduce some newly discovered technologically innovative inducers activate system at level. Furthermore, also discuss clinical applications combing with immunotherapy. This review will provide valuable insights into future development ICD-related combination therapeutics potential management for tumors.
Язык: Английский
Процитировано
9
Chemical Engineering Journal, Год журнала: 2024, Номер 485, С. 150047 - 150047
Опубликована: Фев. 27, 2024
Язык: Английский
Процитировано
8
Bioorganic Chemistry, Год журнала: 2025, Номер 157, С. 108282 - 108282
Опубликована: Фев. 16, 2025
Язык: Английский
Процитировано
0
Chemical Society Reviews, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Intracellular metal ions play essential roles in multiple physiological processes, including catalytic action, diverse cellular intracellular signaling, and electron transfer. It is crucial to maintain ion homeostasis which achieved by the subtle balance of storage release intracellularly along with influx efflux at interface cell membrane. Dysregulation has been identified as a key mechanism triggering programmed death (PCD). Despite importance initiating PCD, molecular mechanisms within these processes are infrequently discussed. An in-depth understanding review role PCD may better uncover novel tools for cancer diagnosis therapy. Specifically, calcium (Ca
Язык: Английский
Процитировано
0
Small, Год журнала: 2024, Номер unknown
Опубликована: Сен. 11, 2024
Abstract Porphyrins, known for generating toxic singlet oxygen ( 1 O 2 ) to combat bacteria, face challenges such as hydrophilicity and limited lifespan yield. Conversely, triterpenoid compounds like ammonium glycyrrhizinate (AG) offer antioxidative antibacterial properties but lack efficacy stability. Combining them in Metal‐Organic Frameworks (MOFs) yields dual‐ligand zirconium (Zr)‐basedMOFs (M‐TG), capitalizing on porphyrins' membrane‐disrupting ability AG's inhibition of bacterial membrane synthesis a synergistic effect. M‐TG resolves activity loss, enhances reactive species (ROS) yield, extends stability, achieving remarkable 99.999% sterilization rate. This innovative approach maximizes ligand through effects, promising significant advancements material design.
Язык: Английский
Процитировано
3
Microchimica Acta, Год журнала: 2024, Номер 191(5)
Опубликована: Апрель 16, 2024
Язык: Английский
Процитировано
1
Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер unknown, С. 135436 - 135436
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
1
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 26, 2024
Abstract Poly(ADP‐ribose) polymerase (PARP) inhibitors are commonly utilized in the clinical management of patients with platinum‐sensitive recurrent and late‐stage ovarian cancer, which constitutes a significant proportion gynecological cancer‐related mortality. Nonetheless, constraints their monofunctional properties limited therapeutic efficacy observed advanced cancer cases necessitate exploration more potent strategies for cancer. The present study describes development QTABI, PARP‐targeting photosensitizer capable producing reactive oxygen species light irradiation. Simultaneously, it exhibits inhibition PARP activity, induction deoxyribonucleic acid (DNA) damage, consequent synthetic lethality. Furthermore, QTABI can effectively promote accumulation cytosolic DNA activate cyclicGMP‐AMP synthase (cGAS)‐stimulator interferon gene (STING) pathway under irradiation, thereby eliciting anti‐tumor immune responses ultimately boosting anti‐cancer efficacy. Collectively, these findings suggest that is multi‐functional photosensitizer, targets DNA‐damaging repair system activates cGAS‐STING pathway, offering promising combination photo‐immunotherapy strategy treating
Язык: Английский
Процитировано
1
Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)
Опубликована: Сен. 26, 2024
The escalating incidence of breast cancer (BC) in women underscores its grave health threat. Current molecular insights into BC's post-adjuvant therapy cure remain elusive, necessitating active treatment explorations. Immunotherapy, notably chemotherapy-induced immunogenic cell death (ICD), has emerged as a promising BC therapy. ICD harnesses chemotherapeutics to activate anti-tumor immunity via DAMPs, fostering long-term T-cell memory and primary cure. Besides chemotherapy drugs, Nanodrugs, traditional Chinese medicine (TCM) ICIs also induce ICD, boosting immune response. ICIs, like PD-1/PD-L1 inhibitors, revolutionize but face limited success cold tumors. Thus, induction combined with is studied extensively for immunotherapy. This article reviews the mechanism related drugs provides reference research development treatment, order explore more effective clinical BC, we hope inducers make vaccines.
Язык: Английский
Процитировано
0