Evaluation of the antineoplastic properties of the photosensitizer biscyanine in 2D and 3D tumor cell models and artificial skin models DOI
Paola Cristina Resende, Izabela Natália Faria Gomes,

Marta Peixoto

et al.

Journal of Photochemistry and Photobiology B Biology, Journal Year: 2024, Volume and Issue: 262, P. 113078 - 113078

Published: Dec. 9, 2024

Language: Английский

Recent advances in organelle-targeted organic photosensitizers for efficient photodynamic therapy DOI
Musa Dirak, Cansu M. Yenici, Safacan Kölemen

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215710 - 215710

Published: Feb. 20, 2024

Language: Английский

Citations

25
Clinical application of immunogenic cell death inducers in cancer immunotherapy: turning cold tumors hot DOI Creative Commons

Yiman Han,

Xin Tian,

Jiaqi Zhai

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: May 7, 2024

Immunotherapy has emerged as a promising cancer treatment option in recent years. In immune “hot” tumors, characterized by abundant cell infiltration, immunotherapy can improve patients’ prognosis activating the function of cells. By contrast, “cold” tumors are often less sensitive to owing low immunogenicity tumor cells, an inhibitory microenvironment, and series immune-escape mechanisms. Immunogenic death (ICD) is cellular process facilitate transformation eliciting innate adaptive responses through release (or exposure to) damage-related molecular patterns. Accumulating evidence suggests that various traditional therapies induce ICD, including chemotherapy, targeted therapy, radiotherapy, photodynamic therapy. this review, we summarize biological mechanisms hallmarks ICD introduce some newly discovered technologically innovative inducers activate system at level. Furthermore, also discuss clinical applications combing with immunotherapy. This review will provide valuable insights into future development ICD-related combination therapeutics potential management for tumors.

Language: Английский

Citations

9
Nb2CTx MXene coating with inhibition of oxidative stress prepared by Marangoni effect for hemodialysis therapy DOI
Yang He, Hanshu Sun, Yan Jie Wang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 485, P. 150047 - 150047

Published: Feb. 27, 2024

Language: Английский

Citations

8
Punicalagin as an Artemis inhibitor synergizes with photodynamic therapy in tumor suppression DOI

Chen Xue-ning,

C. H. Chen,

Zuoan Li

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 157, P. 108282 - 108282

Published: Feb. 16, 2025

Language: Английский

Citations

0
Intracellular metal ion-based chemistry for programmed cell death DOI
Y You, Zhongying Guo, Tyler Wolter

et al.

Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Intracellular metal ions play essential roles in multiple physiological processes, including catalytic action, diverse cellular intracellular signaling, and electron transfer. It is crucial to maintain ion homeostasis which achieved by the subtle balance of storage release intracellularly along with influx efflux at interface cell membrane. Dysregulation has been identified as a key mechanism triggering programmed death (PCD). Despite importance initiating PCD, molecular mechanisms within these processes are infrequently discussed. An in-depth understanding review role PCD may better uncover novel tools for cancer diagnosis therapy. Specifically, calcium (Ca

Language: Английский

Citations

0
Enhanced Stable and Efficient of Dual‐Ligand Zirconium‐Based Metal‐Organic Frameworks for Synergistic Photodynamic Inactivation DOI
Jin Xu, Zhaoyang Ding,

Mingying Wang

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Abstract Porphyrins, known for generating toxic singlet oxygen ( 1 O 2 ) to combat bacteria, face challenges such as hydrophilicity and limited lifespan yield. Conversely, triterpenoid compounds like ammonium glycyrrhizinate (AG) offer antioxidative antibacterial properties but lack efficacy stability. Combining them in Metal‐Organic Frameworks (MOFs) yields dual‐ligand zirconium (Zr)‐basedMOFs (M‐TG), capitalizing on porphyrins' membrane‐disrupting ability AG's inhibition of bacterial membrane synthesis a synergistic effect. M‐TG resolves activity loss, enhances reactive species (ROS) yield, extends stability, achieving remarkable 99.999% sterilization rate. This innovative approach maximizes ligand through effects, promising significant advancements material design.

Language: Английский

Citations

3
Sleep deprivation boosts O2·− levels in the brains of mice as visualized by a Golgi apparatus–targeted ratiometric fluorescence nanosensor DOI
Wei Song, Chunxia Yao, Yangyang Lu

et al.

Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(5)

Published: April 16, 2024

Language: Английский

Citations

1
“Lily of the valley”-like Au@RCA-AS1411 nanoplatforms polyvalent aptamers-targeted drug delivery system for combined photothermal and chemo-tumor cell therapy DOI
Liqian Wang, Fang Wang, Ruyan Zhang

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: unknown, P. 135436 - 135436

Published: Sept. 1, 2024

Language: Английский

Citations

1
A Molecular‐Targeting Photosensitizer to Inhibit DNA Damage Repair System and Induce cGAS‐STING Pathway Activation for Photo‐Immunotherapy of Ovarian Cancer DOI

Lianfeng Fan,

Peng Zhang, Youyu Gan

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Poly(ADP‐ribose) polymerase (PARP) inhibitors are commonly utilized in the clinical management of patients with platinum‐sensitive recurrent and late‐stage ovarian cancer, which constitutes a significant proportion gynecological cancer‐related mortality. Nonetheless, constraints their monofunctional properties limited therapeutic efficacy observed advanced cancer cases necessitate exploration more potent strategies for cancer. The present study describes development QTABI, PARP‐targeting photosensitizer capable producing reactive oxygen species light irradiation. Simultaneously, it exhibits inhibition PARP activity, induction deoxyribonucleic acid (DNA) damage, consequent synthetic lethality. Furthermore, QTABI can effectively promote accumulation cytosolic DNA activate cyclicGMP‐AMP synthase (cGAS)‐stimulator interferon gene (STING) pathway under irradiation, thereby eliciting anti‐tumor immune responses ultimately boosting anti‐cancer efficacy. Collectively, these findings suggest that is multi‐functional photosensitizer, targets DNA‐damaging repair system activates cGAS‐STING pathway, offering promising combination photo‐immunotherapy strategy treating

Language: Английский

Citations

1
Comprehensive review of drug-mediated ICD inhibition of breast cancer: mechanism, status, and prospects DOI Creative Commons
Yang Wang, Rui Yang, Ying Xie

et al.

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 26, 2024

The escalating incidence of breast cancer (BC) in women underscores its grave health threat. Current molecular insights into BC's post-adjuvant therapy cure remain elusive, necessitating active treatment explorations. Immunotherapy, notably chemotherapy-induced immunogenic cell death (ICD), has emerged as a promising BC therapy. ICD harnesses chemotherapeutics to activate anti-tumor immunity via DAMPs, fostering long-term T-cell memory and primary cure. Besides chemotherapy drugs, Nanodrugs, traditional Chinese medicine (TCM) ICIs also induce ICD, boosting immune response. ICIs, like PD-1/PD-L1 inhibitors, revolutionize but face limited success cold tumors. Thus, induction combined with is studied extensively for immunotherapy. This article reviews the mechanism related drugs provides reference research development treatment, order explore more effective clinical BC, we hope inducers make vaccines.

Language: Английский

Citations

0