Biomaterials Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Natural
small-molecule
drugs
have
been
used
for
thousands
of
years
the
prevention
and
treatment
human
diseases.
Most
natural
products
available
on
market
modified
into
various
polymer
materials
improving
solubility,
stability,
targeted
delivery
drugs.
However,
these
nanomedicines
formed
based
carriers
would
produce
severe
problems
such
as
systemic
toxicity
kidney
metabolic
stress.
In
contrast,
carrier-free
by
their
self-assembly
in
water
inherent
advantages
low
toxicity,
good
biocompatibility,
biodegradability.
This
review
summarizes
assembly
process
application
products,
which
are
mainly
driven
multiple
non-covalent
interactions,
includes
single-molecule
assembly,
bimolecular
drug-modified
organogels.
Meanwhile,
molecular
mechanism
involved
different
processes
is
also
discussed.
Self-assembly
simulation
structural
modification
or
traditional
Chinese
medicine
molecules
using
dynamics
computer-assisted
methods
proposed,
will
lead
to
discovery
more
nanomedicine
drug
systems.
Overall,
this
provides
an
important
understanding
strategy
study
multi-molecule
nanomedicines.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
Abstract
The
emergence
of
nanotechnology
has
significantly
promoted
the
development
medical
field,
and
nanomedicines
broadened
application
potential
existing
drugs.
However,
at
present,
many
new
types
suffer
from
poor
stability,
uncertain
safety,
complex
preparation
processes,
high
costs.
nano‐
Chinese
herbal
medicines
(CHMs)
provided
ideas
for
nanomedicines.
Nano‐CHMs
are
simple
to
prepare,
easily
accessible,
possess
stable
reliable
safety.
This
review
highlighted
nanoparticles
with
pharmacological
activities
important
material
basis
CHM
formula
decoctions.
Given
composition
formulas,
article
further
presented
nanoaggregates
exosome‐like
vesicle
nanostructures
in
single
herbs,
self‐assembly
effect
natural
compounds.
For
first
time,
this
systematically
introduced
characteristics
formulas
herbs
then
compounds,
nano‐aggregates
unclear
components
structures
self‐assembled
supramolecular
materials.
It
also
summarized
problems
be
solved
research
CHMs
applications,
aiming
provide
guidance
modernization
‐related
nanoparticles.
Giant,
Год журнала:
2024,
Номер
18, С. 100256 - 100256
Опубликована: Март 26, 2024
In
recent
years,
significant
advancements
in
nanotechnology
have
yielded
remarkable
improvements
biomedical
applications.
Nanocarriers,
harnessed
from
the
principles
of
nanotechnology,
garnered
widespread
utilization
medicine
delivery
and
diagnostics.
However,
progression
nanocarriers
has
been
hindered
by
two
key
challenges:
low
drug
loading
capacity
potential
for
carrier-induced
toxicity.
To
surmount
these
obstacles,
rapid
development
expansion
carrier-free
systems
(CFDDSs)
composed
pure
drugs
prodrugs
emerged
as
a
promising
solution.
Extensive
endeavors
undertaken
to
explore
novel
excipients,
therapeutic
agents,
self-assembly
processes,
mechanisms,
aimed
at
expanding
horizons
CFDDSs
enhancing
their
efficacy.
This
comprehensive
review
provides
an
overview
CFDDSs,
elucidating
mechanisms.
Additionally,
we
examine
diverse
applications
while
shedding
light
on
challenges
ahead
future
clinical
implementation
CFDDSs.
serves
enhance
our
understanding
intricate
mechanisms
governing
nanoassembly
formation
fosters
advancement
expansive
realm
research.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 27, 2024
Abstract
Background
Ulcerative
colitis
(UC)
is
a
chronic
intestinal
inflammation,
resulting
in
global
healthcare
challenge
with
no
real
specific
medicine.
Natural
medicines
are
recognized
as
potential
clinical
alternative
therapy,
but
their
applications
limited
by
poor
solubility
and
low
bioavailability.
Results
In
this
work,
inspired
the
natural
of
ancient
China,
novel
functional
carbon
dots
derived
from
Magnetite
Medicated
Leaven
(MML-CDs)
were
synthesized
hydrothermal
method,
confirmed
ultrasmall
nano-size
(3.2
±
0.6
nm)
Fe
doped
surface
structure,
thereby
excellent
gastrointestinal
stability,
remarkable
capabilities
eliminating
ROS,
highly
biocompatibility.
With
external
stimuli,
oral
administration
MML-CDs
demonstrated
obvious
alleviation
to
UC.
Further
experiments
pointed
that
could
improve
hemostasis
capability,
suppress
inflammation
reactions
oxidative
stress,
up-regulate
expression
tight
junction
proteins.
Furthermore,
also
showed
well
regulation
dysbiosis
flora.
Conclusion
Overall,
above
evidence
reveals
green-synthesized
can
significantly
alleviate
bleeding,
inhibit
colon
repair
colonic
barrier
damage,
further
regulating
flora
microenvironment.
Our
findings
provide
an
efficient
therapy
strategy
for
ulcerative
colitis.
Graphical
Biomaterials Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Natural
small-molecule
drugs
have
been
used
for
thousands
of
years
the
prevention
and
treatment
human
diseases.
Most
natural
products
available
on
market
modified
into
various
polymer
materials
improving
solubility,
stability,
targeted
delivery
drugs.
However,
these
nanomedicines
formed
based
carriers
would
produce
severe
problems
such
as
systemic
toxicity
kidney
metabolic
stress.
In
contrast,
carrier-free
by
their
self-assembly
in
water
inherent
advantages
low
toxicity,
good
biocompatibility,
biodegradability.
This
review
summarizes
assembly
process
application
products,
which
are
mainly
driven
multiple
non-covalent
interactions,
includes
single-molecule
assembly,
bimolecular
drug-modified
organogels.
Meanwhile,
molecular
mechanism
involved
different
processes
is
also
discussed.
Self-assembly
simulation
structural
modification
or
traditional
Chinese
medicine
molecules
using
dynamics
computer-assisted
methods
proposed,
will
lead
to
discovery
more
nanomedicine
drug
systems.
Overall,
this
provides
an
important
understanding
strategy
study
multi-molecule
nanomedicines.
