International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125151 - 125151
Published: Dec. 1, 2024
Language: Английский
BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)
Published: July 11, 2024
Abstract Ulcerative colitis (UC) is a persistent inflammatory condition that specifically targets the colon and rectum. Existing therapies fail to adequately address clinical requirements of people suffering from this ailment. Despite acknowledged potential nanomedicines in field anti-inflammatory treatment, their widespread use settings impeded by expensive nature uncertainty surrounding safety profiles. This study illustrates two naturally occurring phytochemicals, Costunolide (COS) Glycyrrhizic acid (GA), form carrier-free, multifunctional spherical nanoparticles (NPs) through noncovalent interactions, such as π–π stacking hydrogen bonding. The COS-GA NPs displayed synergistic effect, providing much more evidently improved therapeutic benefits for dextran sodium sulfate (DSS)-induced UC mice due effective reduction inflammation oxidative stress than did equal dosages COS or GA used alone. In addition, have biocompatibility biosafety properties unique them. will serve affirmation innovative natural antioxidant activities also agents drug discovery UC, leading possibly better outcomes living with disabling condition.
Language: Английский
Citations
1
Highlights in Science Engineering and Technology, Journal Year: 2024, Volume and Issue: 99, P. 308 - 313
Published: June 18, 2024
Nanodrugs offer a means of delivering drugs that can enhance their bioavailability. However, the practical application nanomedicines is hindered by use carrier materials in construction, which make them potentially toxic. Carrier-free nanomaterials are currently receiving significant attention due to simple composition, high drug loading capacity, and low toxicity, making widely used medical applications. This paper outlines self-assembly mechanism carrierless nanomaterials, details applications antitumour, antibacterial, anti-inflammatory antioxidant applications, finally briefly discusses development nanomaterials.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Dec. 9, 2024
Ulcerative colitis (UC) is a chronic inflammatory condition of the intestinal tract in which mucosal healing crucial measure therapeutic efficacy. Quercetin, flavonoid prevalent various foods and traditional Chinese medicines, exhibits notable pharmacological properties, including antioxidant anti-inflammatory activities. Consequently, it warrants investigation to determine its potential effects on UC. The objective this study was investigate underlying mechanisms quercetin murine model
Language: Английский
Citations
0
Gels, Journal Year: 2024, Volume and Issue: 10(9), P. 569 - 569
Published: Aug. 31, 2024
Chinese herbs are a huge treasure trove of natural products and an important source many active molecules. The theory traditional medicine compatibility (TCMC) is widely applied in clinical practice, but its mechanism still ambiguous. This study aims to open new window for this predicament by studying the interaction between main ingredients from drug pair. Carrier-free assembly improves shortcomings nanodelivery systems opens path development nanomaterials. pair "
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125151 - 125151
Published: Dec. 1, 2024
Language: Английский
Citations
0