ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(24), С. 28876 - 28884
Опубликована: Дек. 10, 2024
Cell
redox
homeostasis
plays
an
important
role
in
mediating
cellular
reactions
and
regulating
biological
responses.
Up
to
now,
numerous
methods
based
on
disrupting
have
been
developed
for
cancer
therapy,
but
the
treatment
efficacy
remains
a
challenges.
Thioredoxin
reductase
(TrxR)
is
highly
overexpressed
cells,
promoting
malignant
tumor
survival.
Inhibiting
TrxR
activity
presents
promising
approach
perturbing
chemotherapy.
Herein,
we
reported
novel
strategy
utilizing
multifunctional
biomimetic
hollow
nanoparticles
(IrSe2)
that
effectively
inhibit
activity,
exhibit
high
reactive
oxygen
species
(ROS)
generation
capacity,
catalyze
cascade
of
intracellular
biochemical
breast
cancer.
In
this
system,
IrSe2
could
deplete
glutathione
(GSH),
thereby
antioxidant
defense
system
further
improving
ROS
levels.
Furthermore,
are
simultaneously
featured
with
peroxidase-
oxidase-like
activities,
generating
increased
ROS.
Both
vitro
vivo
experimental
results
reveal
anticancer
mediated
by
its
nanozyme
inhibition
both
GSH
leading
apoptosis.
This
work
not
only
paves
new
way
designing
high-performance
nanozymes
nanocatalysts
practical
applications
also
underscores
potential
combining
disrupt
enhance
release
as
therapy.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 1868 - 1868
Опубликована: Фев. 21, 2025
The
phosphoinositide
3-kinase
(PI3K)/AKT/mammalian
target
of
the
rapamycin
(mTOR)
pathway
plays
a
crucial
role
in
regulation
autophagy,
cellular
mechanism
vital
for
homeostasis
through
degradation
damaged
organelles
and
proteins.
dysregulation
this
is
significantly
associated
with
cancer
progression,
metastasis,
resistance
to
therapy.
Targeting
PI3K/AKT/mTOR
signaling
presents
promising
strategy
treatment;
however,
traditional
therapeutics
frequently
encounter
issues
related
nonspecific
distribution
systemic
toxicity.
Nanoparticle-based
drug
delivery
systems
represent
significant
advancement
addressing
these
limitations.
Nanoparticles
enhance
bioavailability,
stability,
targeted
therapeutic
agents,
facilitating
precise
modulation
autophagy
cells.
Functionalized
nanoparticles,
such
as
liposomes,
polymeric
metal-based
nanocarriers,
facilitate
tumor
tissues,
minimizing
off-target
effects
improving
efficacy.
These
can
deliver
multiple
agents
concurrently,
enhancing
PI3K/AKT/mTOR-mediated
oncogenic
pathways.
This
review
examines
advancements
nanoparticle-mediated
that
pathway,
emphasizing
their
contribution
precision
side
integration
nanotechnology
molecularly
therapies
substantial
potential
resistance.
Future
initiatives
must
prioritize
optimization
clinical
translation
patient
outcomes.
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 12, 2025
The
continuous
destruction
of
the
global
ecological
environment
has
led
to
increased
natural
disasters
and
adverse
weather,
severely
affecting
crop
yields
quality,
particularly
due
abiotic
stress.
Nanase,
a
novel
artificial
enzyme,
simulates
various
enzyme
activities,
is
renewable,
shows
significant
potential
in
promoting
growth
mitigating
This
study
reviews
classification
nanoenzymes
into
carbon-based,
metal-based,
metal
oxide-based,
others
based
on
synthesis
materials.
catalytic
mechanisms
these
are
discussed,
encompassing
such
as
oxidases,
peroxidases,
catalases,
superoxide
dismutases.
alleviating
salt,
drought,
high-temperature,
low-temperature,
heavy
metal,
other
stresses
crops
also
highlighted.
Furthermore,
challenges
faced
by
especially
sustainable
agricultural
development.
review
provides
insights
applying
agriculture
offers
theoretical
guidance
for
stress
crops.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Abstract
Bone
defects
caused
by
trauma,
infection,
or
tumors
pose
significant
clinical
challenges,
particularly
in
large
with
poor
healing
outcomes.
Traditional
repair
methods
often
fail
to
address
the
complex
regenerative
microenvironment.
This
study
introduces
a
novel
biomimetic
piezoelectric
periosteum‐bone
bilayer
implant
designed
remodel
osteogenic
microenvironment
and
enhance
bone
defect
repair.
The
comprises
an
upper
electrospun
polyvinylidene
fluoride‐curcumin‐loaded
magnesium
metal–organic
framework
(PVDF‐MOF/Cur,
PMC)
periosteum
scaffold
lower
hydroxyapatite@gelatin
methacrylate
(HA@GelMA)
(PMC+HA@GelMA,
PMCG).
In
whole
PMCG
implant,
PMC
improves
properties
of
PVDF
enables
sustained
drug
release
via
Mg‐MOF
loaded
Cur.
Meanwhile,
HA@GelMA
facilitates
marrow
mesenchymal
stem
cells
differentiation
regeneration.
Additionally,
further
accelerates
promoting
neuronal
differentiation,
as
well
enhancing
angiogenesis
regulating
macrophage
polarization.
Transcriptome
sequencing
reveals
that
activates
key
signaling
pathways
associated
angiogenesis,
neurogenesis,
inflammation
regulation,
osteogenesis,
including
HIF‐1α,
PI3K‐Akt,
JAK‐STAT,
TGF‐β
pathways.
Thus,
this
work
highlights
multifunctional
capabilities
remodify
accelerate
repair,
which
offers
promising
platform
for
advancing
tissue
Materials Today Bio,
Год журнала:
2025,
Номер
32, С. 101773 - 101773
Опубликована: Апрель 17, 2025
Bone
and
joint
diseases
are
debilitating
conditions
that
can
result
in
significant
functional
impairment
or
even
permanent
disability.
Multiscale
metal-based
nanocomposites,
which
integrate
hierarchical
structures
ranging
from
the
nanoscale
to
macroscale,
have
emerged
as
a
promising
solution
this
challenge.
These
materials
combine
unique
properties
of
nanoparticles
(MNPs),
such
enzyme-like
activities,
stimuli
responsiveness,
photothermal
conversion,
with
advanced
manufacturing
techniques,
3D
printing
biohybrid
systems.
The
integration
MNPs
within
polymer
ceramic
matrices
offers
degree
control
over
mechanical
strength,
antimicrobial
efficacy,
manner
drug
delivery,
whilst
concomitantly
promoting
processes
osteogenesis
chondrogenesis.
This
review
highlights
breakthroughs
stimulus-responsive
(e.g.,
photo-,
magnetically-,
pH-activated
systems)
for
on-demand
therapy
their
biocomposite
hybrids
containing
cells
extracellular
vesicles
mimic
native
tissue
microenvironment.
applications
these
composites
extensive,
bone
defects,
infections,
tumors,
degenerative
diseases.
emphasizes
enhanced
load-bearing
capacity,
bioactivity,
be
achieved
through
designs.
Notwithstanding
potential
applications,
barriers
progress
persist,
including
challenges
related
long-term
biocompatibility,
regulatory
hurdles,
scalable
manufacturing.
Finally,
we
propose
future
directions,
machine
learning-guided
design
patient-specific
biomanufacturing
accelerate
clinical
translation.
bridge
innovations
macroscale
functionality,
revolutionary
force
field
biomedical
engineering,
providing
personalized
regenerative
solutions
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
Abstract
Pathological
cardiac
hypertrophy,
often
triggered
by
the
excessive
production
and
accumulation
of
reactive
oxygen
nitrogen
species
(RONS),
may
ultimately
lead
to
heart
failure.
The
treatment
myocardial
hypertrophy
involves
antioxidant
stress
therapy.
In
this
study,
coordinating
curcumin
with
ferric
ions
during
synthesis
Prussian
blue
nanoparticles,
a
blue‐curcumin
(PB‐Cur)
nanozyme
is
successfully
engineered
exceptional
(RONS)
elimination
capabilities.
Following
PVP
modification,
PB‐Cur
exhibited
favorable
biocompatibility
stability
in
aqueous
solutions.
Furthermore,
shows
remarkable
reversible
efficacy
against
both
vitro
vivo
models.
After
one
week
treatment,
group
transverse
aortic
constriction
(TAC)‐induced
models
displayed
notable
decrease
fibrosis.
Echocardiographic
findings
also
revealed
substantial
improvement
function
among
TAC
mice
following
administration.
Mechanistically,
through
(ROS)
elimination,
effectively
downregulated
oxidative
stress‐related
pathways,
including
MAPK
PI3K‐Akt,
which
hold
promise
for
treating
diseases.
