Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Окт. 8, 2024
Metastatic
lung
cancer
remains
a
leading
cause
of
death
worldwide,
with
its
intricate
metastatic
cascade
posing
significant
challenges
to
researchers
and
clinicians.
Despite
substantial
progress
in
understanding
this
cascade,
many
aspects
remain
elusive.
Microfluidic-based
vasculature-on-chip
models
have
emerged
as
powerful
tools
research,
enabling
the
simulation
specific
stages
tumor
progression.
In
study,
we
investigate
extravasation
behaviors
A549
cell
subpopulations,
revealing
distinct
differences
based
on
their
phenotypes.
Our
results
show
that
holoclones,
which
exhibit
an
epithelial
phenotype,
do
not
undergo
extravasation.
contrast,
paraclones,
characterized
by
mesenchymal
demonstrate
notable
capacity
for
Furthermore,
observed
paraclones
migrate
significantly
faster
than
holoclones
within
microfluidic
model.
Importantly,
found
depletion
vascular
endothelial
growth
factor
(VEGF)
effectively
inhibits
paraclones.
These
findings
highlight
utility
microfluidic-based
replicating
key
cascade.
The
insights
gained
from
study
underscore
potential
these
advance
precision
medicine
facilitating
assessment
patient-specific
dynamics
drug
responses.
This
approach
could
lead
improved
strategies
predicting
risk
tailoring
personalized
therapies,
potentially
involving
sampling
cells
patients
during
resection
or
biopsies.
Cells,
Год журнала:
2024,
Номер
13(19), С. 1638 - 1638
Опубликована: Окт. 1, 2024
The
3D
bioprinting
technique
has
made
enormous
progress
in
tissue
engineering,
regenerative
medicine
and
research
into
diseases
such
as
cancer.
Apart
from
individual
cells,
a
collection
of
organoids,
can
be
printed
combination
with
various
hydrogels.
It
hypothesized
that
will
even
become
promising
tool
for
mechanobiological
analyses
organoids
their
matrix
environments
highly
defined
precisely
structured
environments,
which
the
mechanical
properties
cell
environment
individually
adjusted.
Mechanical
obstacles
or
bead
markers
integrated
bioprinted
samples
to
analyze
deformations
forces
within
these
constructs,
perform
biophysical
analysis
complex
systems,
are
still
not
standard
techniques.
review
highlights
advances
4D
printing
technologies
integrating
cues
so
next
step
detailed
key
future
directions
organoid
generation
development
disease
model
regeneration
drug
testing
perspective.
Finally,
hydrogels,
pure
natural
synthetic
hydrogels
mixtures,
organoid–cell
co-cultures,
organ-on-a-chip
systems
organoid-organ-on-a
chip
combinations
introduces
use
assembloids
determine
mutual
interactions
different
types
cell–matrix
interferences
specific
biological
environments.
ACS Applied Nano Materials,
Год журнала:
2025,
Номер
8(4), С. 2054 - 2061
Опубликована: Янв. 17, 2025
Diketopyrrolopyrrole
(DPP)
is
now
widely
used
in
the
phototherapy
of
tumors,
but
most
reported
DPP
molecules
have
no
absorption
near-infrared
(NIR)
region.
In
this
study,
3
derivatives
with
donor–acceptor–donor
(D-A-D)
structures
were
designed
and
synthesized,
which
named
OODPP,
OSDPP,
SSDPP
according
to
number
thione
groups.
Their
spectra
are
gradually
red-shifted
an
increase
However,
after
preparation
nanoparticles
(NPs),
OSDPP
NPs
show
maximum
red
shift
peak
at
786
nm
excellent
photothermal
performance
under
NIR
laser
irradiation.
addition,
could
more
effectively
inhibit
tumor
growth
Therefore,
work
provides
a
feasible
method
for
design
DPP-based
phototherapeutic
agents
therapy.
Advanced Therapeutics,
Год журнала:
2024,
Номер
7(6)
Опубликована: Фев. 22, 2024
Abstract
Vascularized
tumor
on
a
chip
(VToC)
entail
emulating
intricate
microvascular
networks
like
those
observed
in
tumors
through
microfluidic
devices,
which
are
meticulously
designed
to
offer
faithful
representation
of
cancer
vitro,
exploration
biology,
evaluation
drug
efficacy,
and
anticipation
patient
responses
therapies.
Compared
conventional
ones,
VToC
systems
hold
advantages
by
creating
milieu
where
physiological
conditions
for
investigating
tumor–host
interactions
pivotal
advancement/therapy
resilience.
Nevertheless,
models
confront
limitations
encompassing
vascular
network
replication,
biological
fidelity,
mechanical/chemical
integrity,
intricacies
architectural
design.
Thus,
drawbacks
inherent
prevailing
models’
intricacies,
attributes,
establishment
imperative.
This
systematic
review
focuses
the
recent
advancements,
technologies
explored
incorporating
models,
vascularization
approaches
investigation,
factors/parameters
affecting
complex
microenvironments
along
with
futuristic
approach
design
strategies,
fabrication
techniques,
understanding
network,
also
spheroid.
A
comprehensive
analysis
based
their
practical
highlights
promising
strategies
possible
applications.
will
be
essential
regarding
complete
overview
future
direction
toward
developing
efficient
compared
state‐of‐the‐art
VToC.
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Ноя. 19, 2024
Acute
and
requiring
attention
problem
of
oncotheranostics
is
a
necessity
for
the
urgent
development
operative
precise
diagnostics
methods,
followed
by
efficient
therapy,
to
significantly
reduce
disability
mortality
citizens.
A
perspective
way
achieve
personalized
treatment
use
methods
evaluation
individual
drug
load,
properties
specific
tumors
effectiveness
selected
other
actual
features
pathology.
Among
vast
diversity
tumor
types-brain
are
most
invasive
malignant
in
humans
with
poor
survival
after
diagnosis.
brain
glioblastoma
shows
exceptionally
high
mortality.
More
studies
urgently
needed
understand
risk
factors
improve
therapy
approaches.
One
actively
developing
approaches
tumor-on-a-chip
(ToC)
concept.
This
review
examines
achievements
recent
years
field
ToC
system
developments.
The
basics
microfluidic
chips
technologies
considered
context
their
applications
solving
oncological
problems.
Then
basic
principles
cultivation
evaluate
main
challengers
implementation
devices,
growing
cell
cultures
possibilities
observation.
culture
types
advantages
being
analyzed.
modeling
angiogenesis
blood-brain
barrier
(BBB)
on
chip,
principally
important
elements
life
system,
were
detail.
interesting
examples
developments
have
been
presented.
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Ноя. 26, 2024
Despite
extensive
efforts
to
unravel
tumor
behavior
and
develop
anticancer
therapies,
most
treatments
fail
when
advanced
clinical
trials.
The
main
challenge
in
cancer
research
has
been
the
absence
of
predictive
models,
accurately
mimicking
tumoral
processes
response
treatments.
microenvironment
(TME)
shows
several
human-specific
physical
chemical
properties,
which
cannot
be
fully
recapitulated
by
conventional
2D
cell
cultures
or
