Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 246, С. 114381 - 114381
Опубликована: Ноя. 15, 2024
Язык: Английский
Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150632 - 150632
Опубликована: Март 24, 2024
Язык: Английский
Процитировано
24
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Май 20, 2024
Skin wound healing is a complex and tightly regulated process. The frequent occurrence reoccurrence of acute chronic wounds cause significant skin damage to patients impose socioeconomic burdens. Therefore, there an urgent requirement promote interdisciplinary development in the fields material science medicine investigate novel mechanisms for healing. Cerium oxide nanoparticles (CeO 2 NPs) are type nanomaterials that possess distinct properties have broad application prospects. They recognized their capabilities enhancing closure, minimizing scarring, mitigating inflammation, exerting antibacterial effects, which has led prominence care research. In this paper, distinctive physicochemical CeO NPs most recent synthesis approaches discussed. It further investigates therapeutic process Following that, review critically examines previous studies focusing on effects Finally, it suggests potential cerium as innovative nanomaterial diverse discusses its prospects future advancements.
Язык: Английский
Процитировано
10
Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)
Опубликована: Март 7, 2025
Abstract Macrophages are immune cells belonging to the mononuclear phagocyte system. They play crucial roles in defense, surveillance, and homeostasis. This review systematically discusses types of hematopoietic progenitors that give rise macrophages, including primitive progenitors, erythro-myeloid stem cells. These have distinct genetic backgrounds developmental processes. Accordingly, macrophages exhibit complex diverse functions body, phagocytosis clearance cellular debris, antigen presentation, response, regulation inflammation cytokine production, tissue remodeling repair, multi-level regulatory signaling pathways/crosstalk involved homeostasis physiology. Besides, tumor-associated a key component TME, exhibiting both anti-tumor pro-tumor properties. Furthermore, functional status is closely linked development various diseases, cancer, autoimmune disorders, cardiovascular disease, neurodegenerative metabolic conditions, trauma. Targeting has emerged as promising therapeutic strategy these contexts. Clinical trials macrophage-based targeted drugs, immunotherapies, nanoparticle-based therapy were comprehensively summarized. Potential challenges future directions targeting also been discussed. Overall, our highlights significance this versatile cell human health which expected inform research clinical practice.
Язык: Английский
Процитировано
1
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Окт. 8, 2024
In diabetic wounds, hyperglycemia-induced cytotoxicity and impaired immune microenvironment plasticity directly hinder the wound healing process. Regulation of hyperglycemic remodeling are crucial.
Язык: Английский
Процитировано
5
Journal of Colloid and Interface Science, Год журнала: 2025, Номер unknown, С. 137401 - 137401
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Materials & Design, Год журнала: 2025, Номер unknown, С. 113714 - 113714
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 24, 2025
Abstract Pathological microenvironment of diabetes including hyperglycemia, excessive reactive oxygen species (ROS), and accumulation advanced glycation end products leads to high risk infection persistent inflammatory reaction, retarding biointegration implants. To address this issue, a dual‐catalysis system consisting Na 2 TiO 3 nanotubes with CeO nanodots polydopamine (PDA) cover is constructed on Ti implant manipulate ROS generation scavenging for antibiosis tissue regeneration. form heterojunction, in which vacancies (VOs) contribute the separation electron‐hole pairs under near‐infrared light (NIR) irradiation. In NIR mode, photocatalysis‐induced photothermal‐induced hyperthermia by ‐CeO heterojunction PDA synergistically kill bacteria efficiently. non‐NIR show excellent superoxide dismutase (SOD) catalases (CAT) like enzyme activities, they catalyze (e.g., ·O − H O ) thoroughly into benign O, relieving oxidative stress accelerating M2 macrophage phenotype. It helps biofunctional recovery endothelial cells fibroblasts, promoting regeneration around implants diabetic models. This work proposes promising approach manipulating treat regulate thereby improving performance microenvironment.
Язык: Английский
Процитировано
0
Carbohydrate Polymers, Год журнала: 2024, Номер 351, С. 122967 - 122967
Опубликована: Ноя. 13, 2024
Язык: Английский
Процитировано
1
ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(7), С. 4195 - 4226
Опубликована: Май 16, 2024
Diabetic foot ulcers (DFU) are chronic, refractory wounds caused by diabetic neuropathy, vascular disease, and bacterial infection, have become one of the most serious persistent complications diabetes mellitus because their high incidence difficulty in healing. Its malignancy results from a complex microenvironment that includes series unfriendly physiological states secondary to hyperglycemia, such as recurrent infections, excessive oxidative stress, inflammation, ischemia hypoxia. However, current common clinical treatments, antibiotic therapy, insulin surgical debridement, conventional wound dressings all drawbacks, suboptimal outcomes exacerbate financial physical burdens patients. Therefore, development new, effective affordable treatments for DFU represents top priority improve quality life In recent years, nanozymes-based therapy systems been attracting extensive interest integrating unique advantages nanomaterials natural enzymes. Compared with enzymes, nanozymes possess more stable catalytic activity, lower production cost greater maneuverability. Remarkably, many multienzyme activities can cascade multiple enzyme-catalyzed reactions simultaneously throughout recovery process DFU. Additionally, favorable photothermal-acoustic properties be exploited further enhancement therapeutic effects. this review we first describe characteristic pathological DFU, then discuss mechanisms applications healing, finally, highlight challenges perspectives nanozyme treatment.
Язык: Английский
Процитировано
0
Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 246, С. 114381 - 114381
Опубликована: Ноя. 15, 2024
Язык: Английский
Процитировано
0