Advanced Healthcare Materials,
Год журнала:
2024,
Номер
14(4)
Опубликована: Дек. 23, 2024
Abstract
The
discovery
of
nanozymes
has
opened
new
possibilities
for
tumor
therapy.
However,
their
reliance
on
the
microenvironment
and
limited
catalytic
efficiency
hinder
broader
applications.
In
this
study,
ruthenium‐phenanthroline
nanoparticles
(Ru‐Phs)
are
synthesized
by
combining
ruthenium
with
phenanthroline
subsequently
coloaded
proton
pump
inhibitor
(PPI)
pantoprazole
into
sodium
alginate
(ALG)
to
form
a
Ru‐Phs‐PPI‐ALG
hydrogel
in
situ
This
demonstrates
excellent
chemodynamic
properties,
forming
gel
within
tissues
gradually
releasing
Ru‐Phs,
which
generates
highly
toxic
reactive
oxygen
species
(ROS)
via
peroxidase‐like
(POD‐like)
activity.
inclusion
PPI
reduced
intracellular
pH
cells,
accelerating
Fenton
reaction
ROS
accumulation.
Additionally,
high
photothermal
conversion
enables
heat
generation
under
near‐infrared
(NIR)
irradiation,
not
only
disrupts
cell
structures
but
also
further
enhances
POD‐like
activity
Ru‐Phs.
effectively
killed
4T1
cells
vitro,
transcriptomic
analysis
confirms
its
potent
efficacy.
vivo
experiments
demonstrate
significant
ablation
biocompatibility.
multipathway
strategy
increase
enzyme
improve
effects
provides
promising
approach
advancing
nanozyme
applications
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(23)
Опубликована: Апрель 5, 2024
Abstract
Reactive
oxygen
species
(ROS)
have
become
an
effective
tool
for
tumor
treatment.
The
combination
of
photodynamic
therapy
(PDT)
and
chemodynamic
(CDT)
takes
advantage
various
ROS
enhances
therapeutic
effects.
However,
the
activation
CDT
usually
occurs
before
PDT,
which
hinders
sustained
maintenance
hydroxyl
radicals
(⋅OH)
reduces
treatment
efficiency.
Herein,
we
present
a
light‐triggered
nano‐system
based
on
molecular
aggregation
regulation
converting
cancer
from
PDT/photothermal
(PTT)
to
long‐lasting
CDT.
ordered
J‐aggregation
properties
cyanine
moiety
while
simultaneously
suppressing
capabilities
copper‐porphyrin
moiety.
Upon
light
irradiation,
Cu‐PCy
JNPs
demonstrate
strong
photothermal
Meanwhile,
triggers
rapid
degradation
backbone,
leading
destruction
J‐aggregation.
As
result,
is
sequentially
activated,
generation
⋅OH
observed
up
48
hours,
causing
potent
cellular
oxidative
stress
apoptosis.
Due
their
excellent
accumulation,
exhibit
in
vivo
ablation
through
therapy.
This
work
provides
new
approach
effectively
prolonging
activity
ROS‐based
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(23)
Опубликована: Апрель 2, 2024
We
present
herein
the
synthesis
of
novel
pseudo-metalla-carbaporphyrinoid
species
(1M:
M=Pd
and
Pt)
achieved
through
inner
coordination
palladium(II)
platinum(II)
with
an
acyclic
N-confused
tetrapyrrin
analogue.
Despite
their
tetrapyrrole
frameworks
being
small,
akin
to
well-known
porphyrins,
these
exhibit
unusually
narrow
HOMO-LUMO
gap,
resulting
in
unprecedentedly
low-energy
absorption
second
near-infrared
(NIR-II)
region.
Density
functional
theory
(DFT)
calculations
revealed
unique
d
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
19(4)
Опубликована: Янв. 17, 2024
Abstract
Malignant
tumors
seriously
threaten
human
life
and
well‐being.
Emerging
Near‐infrared
II
(NIR‐II,
1000–1700
nm)
phototheranostic
nanotechnology
integrates
diagnostic
treatment
modalities,
offering
merits
including
improved
tissue
penetration
enhanced
spatiotemporal
resolution.
This
remarkable
progress
has
opened
promising
avenues
for
advancing
tumor
theranostic
research.
The
microenvironment
(TME)
differs
from
normal
tissues,
exhibiting
distinct
attributes
such
as
hypoxia,
acidosis,
overexpressed
hydrogen
peroxide,
excess
glutathione,
other
factors.
Capitalizing
on
these
attributes,
researchers
have
developed
TME‐activatable
NIR‐II
agents
with
therapeutic
concurrently.
Therefore,
developing
activation
holds
significant
research
importance.
Currently,
is
still
in
its
preliminary
stages.
review
examines
the
recent
advances
dual‐functional
activatable
over
past
years.
It
systematically
presents
activated
by
various
TME
factors
acidity
(pH),
peroxide
(H
2
O
),
glutathione
(GSH),
sulfide
S),
enzymes,
their
hybrid.
encompasses
fluorescence
photoacoustic
imaging
diagnostics,
along
photothermal,
photodynamic,
chemodynamic,
gas
therapies
triggered
Lastly,
difficulties
opportunities
confronting
simultaneous
diagnosis
field
are
highlighted.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(22)
Опубликована: Июнь 11, 2024
Abstract
Calcium
overload
can
lead
to
tumor
cell
death.
However,
because
of
the
powerful
calcium
channel
excretory
system
within
cells,
simplistic
overloads
do
not
allow
for
an
effective
antitumor
therapy.
Hence,
nanoparticles
are
created
with
polyethylene
glycol
(PEG)
donor‐modified
phosphate
(CaP)‐coated,
manganese‐doped
hollow
mesopores
Prussian
blue
(MMPB)
encapsulating
glucose
oxidase
(GOx),
called
GOx@MMPB@CaP‐PEG
(GMCP).
GMCP
a
three‐mode
enhancement
intratumor
reactive
oxygen
species
(ROS)
levels
is
designed
increase
efficiency
intracellular
in
cells
enhance
its
anticancer
efficacy.
The
released
exogenous
Ca
2+
and
production
cytotoxic
ROS
resulting
from
perfect
circulation
outbreak
generation
that
Fenton/Fenton‐like
reaction
consumption
glutathione
Fe
/Fe
3+
Mn
/Mn
circle,
amelioration
hypoxia
MMPB‐guided
GOx‐mediated
starvation
Photothermal
efficacy‐induced
heat
owing
MMPB
accelerates
above
reactions.
Furthermore,
abundant
contribute
damage
mitochondria,
channels
efflux
inhibited,
overload.
further
increases
promotes
apoptosis
achieve
excellent
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 30, 2024
Photothermal
therapy
(PTT)
is
a
promising
approach
for
treating
tumors
that
offers
multiple
advantages.
Nevertheless,
its
practical
use
in
clinical
settings
faces
several
limitations,
such
as
suboptimal
delivery
efficiency,
uneven
heat
distribution,
and
challenges
predicting
optimal
treatment
duration.
In
addition,
the
localized
hyperthermia
generated
by
PTT
method
to
induce
cell
apoptosis
can
result
production
of
excessive
reactive
oxygen
species
(ROS)
release
inflammatory
cytokines,
which
pose
threat
healthy
tissues
surrounding
tumor.
To
address
above
challenges,
this
work
designs
an
integrated
H
Materials & Design,
Год журнала:
2024,
Номер
240, С. 112815 - 112815
Опубликована: Март 12, 2024
Establishing
a
phototheranostic
platform
constructed
by
the
second
near-infrared
(NIR-II)
region
has
proved
revolutionary
and
promising
strategy
for
cancer
treatment.
However,
antitumor
effectiveness
is
severely
limited
monotonicity
of
NIR-photothermal
therapy
(HPTT)
modality
tumor
thermotolerance
caused
production
heat
shock
proteins
(HSPs).
Here,
minimalistic
approach
used
to
construct
an
organic
nanoplatform
(IFT@PEG-GOX
NPs)
with
reciprocal
cyclic
promotion
hypothermia
starvation
treatments
NIR-II
imaging-guided
therapy.
After
enhanced
permeability
retention
(EPR)
effect
causes
IFT@PEG-GOX
NPs
accumulate
in
tumors,
glucose
oxidase
(GOx)-mediated
may
obstruct
adenosine
triphosphate
(ATP)
downregulation
(HSPs),
thereby
reducing
cells.
that,
sensitized
HPTT
was
activated
GOx's
catalytic
activity
increased
NIR
laser
irradiation.
Then,
there
would
be
subsequent,
intensified
inhibition
HSP
along
additional
amplification
GOx-mediated
starvation.
As
consequence,
HPTT/Starvation
(ST)
bidirectional
cycle
method
initiated,
leading
enhancing
impact
ST
significantly
better
suppression.
Angewandte Chemie,
Год журнала:
2024,
Номер
136(23)
Опубликована: Апрель 5, 2024
Abstract
Reactive
oxygen
species
(ROS)
have
become
an
effective
tool
for
tumor
treatment.
The
combination
of
photodynamic
therapy
(PDT)
and
chemodynamic
(CDT)
takes
advantage
various
ROS
enhances
therapeutic
effects.
However,
the
activation
CDT
usually
occurs
before
PDT,
which
hinders
sustained
maintenance
hydroxyl
radicals
(⋅OH)
reduces
treatment
efficiency.
Herein,
we
present
a
light‐triggered
nano‐system
based
on
molecular
aggregation
regulation
converting
cancer
from
PDT/photothermal
(PTT)
to
long‐lasting
CDT.
ordered
J‐aggregation
properties
cyanine
moiety
while
simultaneously
suppressing
capabilities
copper‐porphyrin
moiety.
Upon
light
irradiation,
Cu‐PCy
JNPs
demonstrate
strong
photothermal
Meanwhile,
triggers
rapid
degradation
backbone,
leading
destruction
J‐aggregation.
As
result,
is
sequentially
activated,
generation
⋅OH
observed
up
48
hours,
causing
potent
cellular
oxidative
stress
apoptosis.
Due
their
excellent
accumulation,
exhibit
in
vivo
ablation
through
therapy.
This
work
provides
new
approach
effectively
prolonging
activity
ROS‐based
