ACS Omega,
Год журнала:
2024,
Номер
9(49), С. 48642 - 48649
Опубликована: Ноя. 25, 2024
Oxidative
stress
and
inflammation
are
key
pathological
features
of
atherosclerotic
plaques.
Numerous
nanomedicines
have
been
developed
to
alleviate
oxidative
reduce
within
However,
nonbioactive
carrier
materials
the
bioavailability
may
pose
potential
biological
toxicity.
In
this
study,
we
utilized
unique
amphiphilic
chemical
structure
lipoic
acid
(LA)
prepare
LA
nanoparticles
(LA
NPs)
via
a
self-assembly
method.
Leveraging
inherent
anti-inflammatory
antioxidant
properties
LA,
these
NPs
were
used
for
treatment
atherosclerosis.
an
inflammatory
macrophage
model,
exhibited
superior
activity
compared
free
LA.
Through
ultrasound
imaging
methods,
discovered
that
demonstrated
nice
antiatherosclerotic
effects
in
mice
model.
Immunofluorescence
analysis
further
indicated
associated
with
alleviation
plaques,
reduced
infiltration,
downregulation
cytokine
levels.
Therefore,
offer
promising
therapeutic
strategy
Biomedical Technology,
Год журнала:
2024,
Номер
7, С. 1 - 14
Опубликована: Июнь 5, 2024
Cardiovascular
disease
(CVD)
remains
a
leading
cause
of
mortality
worldwide,
claiming
countless
lives
and
posing
formidable
health
challenge.
Extensive
efforts
have
been
dedicated
to
combating
this
disease,
including
the
development
innovative
biomaterials
for
blood
vessel
stents,
drug
delivery
imaging
diagnosis.
These
advancements
substantially
addressed
issues
such
as
patient
rejection
contamination.
In
review,
we
begin
by
outlining
prevalence
various
forms
CVD.
Subsequently,
delve
into
advanced
biomaterials—including
synthetic
biomaterials,
natural
hybrid
biomaterials—and
medical
instruments
used
in
treatment
or
alleviation
CVD,
discussing
their
advantages
limitations.
Finally,
offer
insights
future
prospects
strategies
refining
these
technologies
moving
forward.
Polymers,
Год журнала:
2025,
Номер
17(5), С. 625 - 625
Опубликована: Фев. 26, 2025
Atherosclerosis
(AS)
is
an
important
causative
agent
of
cardiovascular
diseases,
and
the
occurrence
development
AS
accompanied
by
oxidative
stress,
so
antioxidant
therapy
has
become
one
strategies
for
treatment
AS.
This
study
aimed
to
design
construct
apolipoprotein
ApoA1-modified
inorganic-organic
composite
nanosystem
therapy,
in
which
ApoA1
was
modified
onto
carboxylated
CeO2/Mn3O4
covalent
bonding,
resulting
nanocomplex
with
a
structure
similar
that
high-density
lipoprotein.
The
could
effectively
deliver
nanoparticles
plaque
through
specific
recognition
between
macrophage
at
lesion
site.
For
thing,
alleviate
stress
environment
site
highly
efficient
effect
CeO2/Mn3O4,
played
therapeutic
role
another,
it
eliminate
formed
lipid
plaques
maximally
treat
utilizing
cholesterol
efflux
ApoA1.
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 13
Опубликована: Март 20, 2025
Atherosclerosis
is
the
leading
cause
of
cardiovascular
disease
worldwide,
posing
not
only
a
significant
threat
to
health
but
also
impairing
function
multiple
organs,
with
severe
cases
potentially
being
life-threatening.
Consequently,
effective
treatment
atherosclerosis
paramount
importance
in
reducing
mortality
associated
diseases.
With
advancement
nanomedicine
and
deeper
understanding
pathological
mechanisms
underlying
atherosclerosis,
nanomaterials
have
emerged
as
promising
platforms
for
precise
diagnosis
targeted
therapeutic
strategies.
These
materials
offer
notable
advantages,
including
drug
delivery,
enhanced
bioavailability,
improved
stability,
controlled
release.
This
review
provides
an
overview
atherosclerotic
plaque
development
examines
nanomaterial-based
approaches
managing
plaques,
therapies
targeting
cholesterol
metabolism,
anti-inflammatory
strategies,
macrophage
clearance,
immunotherapy.
Additionally,
paper
discusses
current
technical
challenges
clinical
transformation
these
therapies.
Finally,
potential
future
integration
nanomaterials,
smart
artificial
intelligence
explored.
Pharmaceutics,
Год журнала:
2025,
Номер
17(2), С. 240 - 240
Опубликована: Фев. 12, 2025
Atherosclerosis
is
a
chronic
progressive
disease
which
known
to
cause
acute
cardiovascular
events
as
well
cerebrovascular
with
high
mortality.
Unlike
many
other
diseases,
atherosclerosis
often
diagnosed
only
after
an
or
fatal
event.
At
present,
the
clinical
problems
of
mainly
involve
difficulty
in
confirming
plaques
identifying
stability
early
phase.
In
recent
years,
development
nanotechnology
has
come
various
advantages
including
non-invasive
imaging
enhancement,
can
be
studied
for
atherosclerosis.
For
targeted
and
treatment,
nanoliposomes
provide
enhanced
stability,
drug
administration,
extended
circulation,
less
toxicity.
This
review
discusses
current
advances
tailored
liposomal
nano-radiopharmaceutical-based
techniques
their
applications
atherosclerotic
plaque
diagnosis.
further
highlights
nano-radiopharmaceutical
localisation
biodistribution-key
processes
pathophysiology
Finally,
this
direction
future
nano-radiopharmaceuticals
potential
tool
assessment
diagnosis
plaque.
Timely
detection
of
early
atherosclerosis
(AS)
is
crucial
for
improving
cardiovascular
outcomes,
creating
a
growing
demand
diagnostic
tools
that
are
simple,
sensitive,
and
cost-effective.
Here,
we
introduce
synthetic
nanosensor
AS
leverages
the
fluorescence
renal
clearance
properties
carbon
quantum
dots
(CQDs).
This
nanosensor,
designed
to
respond
proteolytic
activity
AS-associated
dysregulated
enzymes,
entails
CQDs
as
signal
reporters
convert
fluorometric
readings
enabling
sensitive
cost-effective
urine-based
assay
detection.
Our
findings
demonstrated
provided
distinct
signals
in
atherosclerotic
versus
healthy
mice
at
stages,
indicating
its
potential.
Moreover,
toxicity
tests
showed
no
notable
adverse
effects,
supporting
safety
applications.
minimally
invasive
approach
could
facilitate
personalized
therapy
design
continuous
efficacy
assessment.
It
expected
such
modular
platform
can
be
integrated
with
simple
urine
offer
various
diseases.
Molecular Pharmaceutics,
Год журнала:
2024,
Номер
21(10), С. 4804 - 4826
Опубликована: Сен. 3, 2024
Atherosclerosis
is
a
vascular
intima
condition
in
which
any
part
of
the
circulatory
system
affected,
including
aorta
and
coronary
arteries.
Indocyanine
green
(ICG),
theranostic
compound
approved
by
FDA,
has
shown
promise
treatment
atherosclerosis
after
incorporation
into
nanoplatforms.
By
integration
ICG
with
targeting
agents
such
as
peptides
or
antibodies,
it
feasible
to
increase
its
concentration
damaged
arteries,
hence
increasing
detection.
Nanotheranostics
offers
cutting-edge
techniques
for
clinical
diagnosis
therapy
atherosclerotic
plaques.
Combining
optical
properties
those
nanocarriers
enables
improved
imaging
plaques
targeted
therapeutic
interventions.
Several
ICG-based
nanotheranostics
platforms
have
been
developed
polymeric
nanoparticles,
iron
oxide
biomimetic
systems,
liposomes,
peptide-based
etc.
Theranostics
use
magnetic
resonance
(MRI),
computed
tomography
(CT),
near-infrared
fluorescence
(NIRF)
imaging,
photoacoustic/ultrasound
positron
emission
(PET),
single
photon
(SPECT)
techniques.
In
addition
there
growing
interest
employing
treat
atherosclerosis.
this
review,
we
provide
conceptual
explanation
Moreover,
advancements
modalities
MRI,
CT,
PET,
SPECT,
ultrasound/photoacoustic
discussed.
Furthermore,
highlight
applications
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(37), С. 9144 - 9154
Опубликована: Янв. 1, 2024
Cardiovascular
disease
(CVD)
is
a
global
health
concern,
presenting
significant
risks
to
human
health.
Atherosclerosis
among
the
most
prevalent
CVD,
impacting
medium
and
large
arteries
in
kidneys,
brain,
heart,
other
vital
organs,
as
well
lower
limbs.
As
progresses,
arterial
obstruction
can
result
heart
attacks
strokes.
Therefore,
patients
with
atherosclerosis
should
receive
accurate
diagnosis
timely
therapeutic
intervention.
With
advancements
nanomedicine,
researchers
have
proposed
new
research
strategies
methods
for
imaging.
This
paper
summarizes
some
current
findings
on
use
of
nanomaterials
diagnosing
offers
insights
optimizing
imaging
applications
future.
