Abstract
Osteoarthritis
(OA)
is
a
progressively
developing
condition
primarily
characterized
by
the
deterioration
of
articular
cartilage
and
proliferation
bone,
along
with
ongoing
inflammation.
Although
precise
pathogenesis
remains
somewhat
elusive,
restoring
homeostatic
balance
intra‐articular
microenvironment
crucial
for
management
OA.
Intra‐articular
injection
medication
one
most
direct
effective
treatment
methods;
however,
injectable
drugs
used
osteoarthritis
treatment,
due
to
their
rapid
breakdown,
quick
release,
poor
biological
activity,
frequent
injections,
leading
increased
risk
infection
suboptimal
therapeutic
outcomes.
In
this
study,
lubricating
dual‐responsive
hydrogel
based
on
zeolitic
imidazolate
frameworks‐8
(ZIF‐8)
impregnated
Quercetin
(Que)
designed,
which
can
facilitate
OA
remodeling
microenvironment.
The
prepared
nanocomposite
(MH/CCM@ZIF‐8@Que)
exhibits
pH
reactive
oxygen
species
(ROS)
responsiveness,
alongside
controllable
release
bioactive
substances
modulate
bone
tissue,
thereby
mitigating
synovitis
degeneration
matrix,
while
simultaneously
facilitating
repair.
This
developed
thermosensitive
hydrogel,
effectively
balances
lubrication
controlled
substances,
represents
highly
promising
approach
osteoarthritis.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(17)
Опубликована: Фев. 7, 2024
Abstract
Osteoarthritis
is
a
degenerative
joint
disease
characterized
by
cartilage
deterioration
and
subsequent
inflammatory
changes
in
the
underlying
bone.
Injectable
hydrogels
have
emerged
as
promising
approach
for
controlled
drug
delivery
therapies.
This
review
focuses
on
latest
developments
utilizing
injectable
vehicles
targeted
to
promote
repair
regeneration.
The
pathogenesis
of
osteoarthritis
discussed
provide
comprehensive
understanding
progression.
Subsequently,
various
types
used
intra‐articular
are
discussed.
Specifically,
physically
chemically
crosslinked
critically
analyzed,
with
an
emphasis
their
fabrication
strategies
capacity
encapsulate
release
therapeutic
agents
manner.
Furthermore,
potential
incorporating
growth
factors,
anti‐inflammatory
drugs,
cells
within
these
Overall,
this
offers
guide
navigating
landscape
hydrogel‐based
therapeutics
osteoarthritis.
Theranostics,
Год журнала:
2024,
Номер
14(11), С. 4198 - 4217
Опубликована: Янв. 1, 2024
The
utilization
of
extracellular
vesicles
(EVs)
in
wound
healing
has
been
well-documented.However,
the
direct
administration
free
EVs
via
subcutaneous
injection
at
sites
may
result
rapid
dissipation
bioactive
components
and
diminished
therapeutic
efficacy.Functionalized
hydrogels
provide
effective
protection,
as
well
ensure
sustained
release
bioactivity
during
process,
making
them
an
ideal
candidate
material
for
delivering
EVs.In
this
review,
we
introduce
mechanisms
by
which
accelerate
healing,
then
elaborate
on
construction
strategies
engineered
EVs.Subsequently,
discuss
synthesis
application
delivery
systems
to
enhance
complicated
healing.Furthermore,
face
wounds,
functionalized
with
specific
microenvironment
regulation
capabilities,
such
antimicrobial,
anti-inflammatory,
immune
regulation,
used
loading
EVs,
potential
approaches
addressing
these
challenges.Ultimately,
deliberate
future
trajectories
outlooks,
offering
a
fresh
viewpoint
advancement
artificial
intelligence
(AI)-energized
materials
3D
bio-printed
multifunctional
hydrogel-based
dressings
biomedical
applications.
Bioactive Materials,
Год журнала:
2024,
Номер
41, С. 61 - 82
Опубликована: Июль 12, 2024
Despite
numerous
studies
on
chondrogenesis,
the
repair
of
cartilage-particularly
reconstruction
cartilage
lacunae
through
an
all-in-one
advanced
drug
delivery
system
remains
limited.
In
this
study,
we
developed
a
lacuna-like
hydrogel
microsphere
endowed
with
integrated
biological
signals,
enabling
sequential
immunomodulation
and
endogenous
articular
regeneration.
We
first
chondrogenic
growth
factor
transforming
factor-β3
(TGF-β3)
into
mesoporous
silica
nanoparticles
(MSNs).
Then,
TGF-β3@MSNs
insulin-like
1
(IGF-1)
were
encapsulated
within
microspheres
made
polydopamine
(pDA).
final
step,
factor-loaded
MSN@pDA
chitosan
(CS)
containing
platelet-derived
factor-BB
(PDGF-BB)
blended
to
produce
factors
loaded
composite
(GFs@μS)
using
microfluidic
technology.
The
presence
pDA
reduced
initial
acute
inflammatory
response,
early,
robust
release
PDGF-BB
aided
in
attracting
stem
cells.
Over
subsequent
weeks,
continuous
IGF-1
TGF-β3
amplified
chondrogenesis
matrix
formation.
μS
incorporated
acellular
extracellular
(ACECM)
combined
polydopamine-modified
polycaprolactone
(PCL)
structure
tissue-engineered
scaffold
that
mimicked
evenly
distributed
matrix,
resulting
enhanced
patellar
protection.
This
research
provides
strategic
pathway
for
optimizing
ensuring
prolonged
microenvironmental
remodeling,
leading
efficient
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Май 28, 2024
The
repair
of
irregular
bone
tissue
suffers
severe
clinical
problems
due
to
the
scarcity
an
appropriate
therapeutic
carrier
that
can
match
dynamic
and
complex
damage.
Fortunately,
stimuli-responsive
in
situ
hydrogel
systems
are
triggered
by
a
special
microenvironment
could
be
ideal
method
regenerating
because
injectability,
gelatin,
spatiotemporally
tunable
drug
release.
Herein,
we
introduce
two
main
stimulus-response
approaches,
exogenous
endogenous,
forming
hydrogels
engineering.
First,
summarize
specific
distinct
responses
extensive
range
external
stimuli
(e.g.,
ultraviolet,
near-infrared,
ultrasound,
etc.)
form
created
from
biocompatible
materials
modified
various
functional
groups
or
hybrid
nanoparticles.
Furthermore,
“smart”
hydrogels,
which
respond
endogenous
physiological
environmental
temperature,
pH,
enzyme,
etc.),
achieve
gelation
one
injection
vivo
without
additional
intervention.
Moreover,
mild
chemistry
response-mediated
also
offer
fascinating
prospects
engineering,
such
as
Diels–Alder,
Michael
addition,
thiol-Michael
Schiff
reactions,
etc.
recent
developments
challenges
smart
their
application
administration
engineering
discussed
this
review.
It
is
anticipated
advanced
strategies
innovative
ideas
will
exploited
field
increase
quality
life
for
patients
with
Engineered
biomaterials
are
materials
specifically
designed
to
interact
with
biological
systems
for
biomedical
applications.
This
paper
offers
the
comprehensive
analysis
of
global
clinical
trial
trends
involving
such
materials.
We
surveyed
834
studies
in
ClinicalTrials.gov
database
and
explored
biomaterial
types,
their
initiation
points,
durations
trials.
Predominantly,
synthetic
natural
polymers,
particularly
silicone
collagen,
used.
Trials,
focusing
on
ophthalmology,
dentistry,
vascular
medicine,
primarily
conducted
United
States,
Canada,
Italy.
These
trials
encompass
a
broad
demographic,
enrolled
fewer
than
100
participants.
The
study
duration
varied
ranging
from
0.5
4.5
years.
mainly
bioresorbable
or
bioinert,
integration
cells
remaining
an
underexplored
area.
Our
findings
shed
light
current
practices
future
potentials
engineered
research,
offering
insights
advancing
this
dynamic
field
globally.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(17), С. 4148 - 4161
Опубликована: Янв. 1, 2024
Cyaonoside
A
(CyA),
derived
from
the
natural
Chinese
medicine,
Cyathula
officinalis
Kuan,
which
was
for
a
long
time
used
to
treat
knee
injuries
and
relieve
joint
pain
in
traditional
showed
an
unclear
mechanism
protecting
cartilage.
In
addition,
CyA
poorly
hydrosoluble
incapable
of
being
injected
directly
into
cavity,
limited
its
clinical
application.
This
study
reveals
that
resisted
IL-1β-mediated
chondrogenic
inflammation
apoptosis.
Next,
transcriptome
sequencing
is
explore
potential
mechanisms
underlying
regulation
MSC
differentiation.
Based
on
these
findings,
CyA-loaded
composite
hydrogel
microspheres
(HLC)
were
developed
they
possessed
satisfactory
loading
efficiency,
suitable
degradation
rate
good
biocompatibility.
HLC
increased
anabolic
gene
(Acan,
COL2A,
SOX9)
expression,
while
downregulating
expression
catabolic
marker
MMP13
vitro.
osteoarthritis
mouse
model,
demonstrated
promising
therapeutic
capabilities
by
integrity
articular
conclusion,
this
provides
insights
regulatory
chondrocytes
proposes
microsphere-based
advanced
strategy
osteoarthritis.
Abstract
Minerals
play
a
vital
role,
working
synergistically
with
enzymes
and
other
cofactors
to
regulate
physiological
functions
including
tissue
healing
regeneration.
The
bioactive
characteristics
of
mineral‐based
nanomaterials
can
be
harnessed
facilitate
in
situ
regeneration
by
attracting
endogenous
progenitor
stem
cells
subsequently
directing
tissue‐specific
differentiation.
Here,
cellular
responses
human
mesenchymal
stem/stromal
traditional
nanomaterials,
such
as
hydroxyapatite,
whitlockite,
silicon‐dioxide,
the
emerging
synthetic
2D
nanosilicates
are
investigated.
Transcriptome
sequencing
is
utilized
probe
response
determine
significantly
affected
signaling
pathways
due
exposure
these
inorganic
nanomaterials.
profiles
treated
reveals
stabilized
skeletal
state
suggestive
endochondral
This
observation
bolstered
enhanced
deposition
matrix
mineralization
nanosilicate
compared
control
or
treatments.
Specifically,
use
directs
osteogenic
differentiation
via
activation
bone
morphogenetic
proteins
hypoxia‐inducible
factor
1‐alpha
pathway.
study
provides
insight
into
impact
on
gene
expression
profile
predicts
downstream
effects
nanomaterial
induction
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 10, 2025
Bacterial
infection,
a
complex
wound
microenvironment,
and
persistent
inflammatory
response
in
acute
wounds
can
result
delayed
healing
abnormal
scar
formation,
thereby
compromising
the
normal
function
aesthetic
appearance
of
skin
tissue.
This
issue
represents
one
most
challenging
problems
clinical
practice.
study
aims
to
develop
hydrogel
dressing
specifically
designed
for
treatment
wounds,
providing
immediate
effective
protection
affected
areas.
innovation
seeks
offer
novel
advanced
solution
management
wounds.
In
this
study,
composite
scaffold
was
synthesized
through
reaction
between
oxidized
glycyrrhizic
acid
carboxymethyl
chitosan
Schiff
base.
The
material
properties
were
systematically
characterized,
its
biocompatibility
antibacterial
efficacy
rigorously
evaluated.
A
rat
model
established
compare
multiple
groups,
assessing
impact
on
microenvironment
repair.
results
demonstrated
that
OGA-CMCS
exhibited
excellent
injectability,
biocompatibility,
properties.
It
capable
enhancing
which
turn
influenced
polarization
macrophages
from
M1
M2
phenotype,
mitigating
response,
promoting
angiogenesis
granulation
tissue
regeneration,
accelerating
healing.
successfully
developed
glycyrrhizin-based
dressing,
not
only
introduces
innovative
approaches
emergency
surface
defects
but
also
provides
an
experimental
foundation.
is
anticipated
contribute
significantly
addressing
relevant
challenges.
