Injectable Self-Assembling Procyanidin Nanospheres for Effective Osteoarthritis Treatment
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 1133 - 1145
Опубликована: Янв. 1, 2025
Osteoarthritis
(OA),
a
prevalent
joint
disease,
causes
immense
suffering
to
thousands
of
patients,
impairing
their
mobility
and
diminishing
quality
life.
Current
treatment
methods
primarily
rely
on
analgesics
or
anti-inflammatory
drugs
alleviate
symptoms
but
fail
achieve
the
desired
therapeutic
outcome.
To
better
realize
effects
OA,
procyanidins
(PAs),
as
type
plant
flavonoids
with
strong
antioxidant
activities,
were
designed
self-assembly
well-dispersible
Pluronic
F127
(PF127)
through
hydrogen-bond
interaction
present
an
injectable,
biocompatibility
PA
nanospheres.
These
nanospheres
significantly
increased
cell
viability
in
mouse
L929
fibroblasts
ADTC5
chondrocytes
compared
unassembled
PAs.
In
addition,
self-assembling
PAs/PF127
enhanced
protein
expression
collagen
(COL1A1
COL3A1)
fibroblasts,
glycosaminoglycan
COL2A1
was
also
higher
than
PAs
chondrocytes,
this
heralded
potential
OA
repair
strategies
at
cellular
level.
enzymolysis
model
rat
reduce
space
swelling
early
stages
cartilage
destruction
accelerate
formation
subchondral
bone
cartilaginous
surface.
This
study
offers
valuable
insights
into
preparation
novel
for
effective
OA.
Язык: Английский
Application and progress of smart hydrogel microspheres for regulating oxidative stress in osteoarthritis
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 160620 - 160620
Опубликована: Фев. 1, 2025
Язык: Английский
Targeting inflammation with hyaluronic acid-based micro- and nanotechnology: A disease-oriented review
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
280, С. 135923 - 135923
Опубликована: Сен. 23, 2024
Язык: Английский
Suppressive effect of curcumin on apoptosis of articular chondrocytes via regulation on NF-κB pathway and NLRP3 inflammasome
Cytotechnology,
Год журнала:
2025,
Номер
77(2)
Опубликована: Янв. 31, 2025
Язык: Английский
Exploration of scientific connotation of “Yin-Jing” medical properties of Cyathula Officinalis via potentiating therapeutic effect, guidance and targetability
Journal of Ethnopharmacology,
Год журнала:
2025,
Номер
unknown, С. 119629 - 119629
Опубликована: Март 1, 2025
Язык: Английский
Current Status and Perspectives of Research on Polymer Hydrogels in the Treatment and Protection of Osteoarthritis
Macromolecular Bioscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
Abstract
Arthritis
is
a
degenerative
disease
characterized
by
chronic
cartilage
degeneration.
It
affects
hundreds
of
millions
people
worldwide
and
often
has
serious
consequences
such
as
joint
pain
swelling,
limited
mobility,
deformity.
However,
conventional
treatments
still
struggle
to
achieve
satisfactory
results.
Finding
more
effective
for
arthritis
remains
an
important
clinical
challenge.
As
hydrogels
have
unique
3D
spatial
mesh
structure,
significant
material
interaction
ability,
adjustable
mechanical
properties,
good
biodegradability,
they
can
provide
suitable
cellular
or
tissue
microenvironment,
their
potential
in
scaffolding
effect,
lubrication,
anti‐inflammatory
drug
delivery
expected
be
potent
therapeutic
approach
the
treatment
osteoarthritis.
In
this
review,
three
aspects
hydrogel
products
osteoarthritis
are
comprehensively
summarized
discussed,
namely,
selection
gel
design,
exploration
cross‐linking
mechanisms,
mechanisms
therapy
osteoarthritis,
focus
on
advantages
limitations
applications,
which
point
out
direction
development
strategy
innovative
field,
applied
research,
transformation.
Язык: Английский