Hydrogel-exosome system in tissue engineering: A promising therapeutic strategy
Bioactive Materials,
Год журнала:
2024,
Номер
38, С. 1 - 30
Опубликована: Апрель 23, 2024
Characterized
by
their
pivotal
roles
in
cell-to-cell
communication,
cell
proliferation,
and
immune
regulation
during
tissue
repair,
exosomes
have
emerged
as
a
promising
avenue
for
"cell-free
therapy"
clinical
applications.
Hydrogels,
possessing
commendable
biocompatibility,
degradability,
adjustability,
physical
properties
akin
to
biological
tissues,
also
found
extensive
utility
engineering
regenerative
repair.
The
synergistic
combination
of
hydrogels
holds
the
potential
not
only
enhance
efficiency
but
collaboratively
advance
repair
process.
This
review
has
summarized
advancements
made
over
past
decade
research
hydrogel-exosome
systems
regenerating
various
tissues
including
skin,
bone,
cartilage,
nerves
tendons,
with
focus
on
methods
encapsulating
releasing
within
hydrogels.
It
critically
examined
gaps
limitations
current
research,
whilst
proposed
future
directions
applications
this
innovative
approach.
Язык: Английский
Polypropylene Mesh Coated with Dual Cross‐Linked Hyaluronic Acid/Polyvinyl Alcohol Composite Hydrogel with Antiadhesion and Angiogenesis Properties for Abdominal Wall Repair
Advanced Materials Technologies,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 22, 2025
Abstract
Development
of
an
antiadhesion
polypropylene
(PP)
mesh
in
hernia
repair
is
a
recognized
need
because
its
efficacy
limited
by
severe
abdominal
adhesions.
The
porous
structure
PP
can
facilitate
the
integration
between
prosthetic
material
and
tissue
promote
wall
defect.
Herein,
composite
hydrogel
coating
composed
polyvinyl
alcohol
(PVA)
hyaluronic
acid
methacrylate
(HAMA)
fabricated
on
surface
through
ultraviolet
photopolymerization
combined
with
freezing–thawing
method.
resulted
coated
retain
43.33%
pore
this
way.
In
vitro
tests
proved
as‐prepared
exhibit
excellent
hydrophilicity
biocompatibility.
Meanwhile,
shows
good
stability
phosphate
buffered
saline
medium.
After
implantation
rat
defect
model,
modified
effectively
prevents
formation
adhesion
reducing
inflammatory
response
suppressing
excessive
deposition
collagen
fiber.
Immunohistochemical
staining
results
demonstrate
that
not
only
decrease
expression
IL‐6,
TNF‐α,
CD68
but
also
CD31.
Thus,
type
preventing
postoperative
adhesions
improving
angiogenesis
may
be
promising
clinical
material.
Язык: Английский
Prevascularized Hydrogel Enhancing Innervation and Repair of Full‐Thickness Volumetric Muscle Loss in Abdominal Wall Defects
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 9, 2025
Current
materials
for
repairing
abdominal
peritoneal
defects
face
rapid
degradation,
infection
risk,
insufficient
vascular
ingrowth,
slow
muscle
regeneration,
and
suboptimal
postoperative
integration,
often
causing
fibrotic
healing
hindering
volumetric
loss
(VML)
repair
exceeding
30%.
To
address
these
issues,
photo-cross-linkable
gelatin
hydrogels
are
combined
with
blood
vessel-forming
cells
to
reconstruct
networks,
providing
temporary
nutrient
gas
channels
that
support
cell
repair.
By
developing
a
polymer-chain
propagation
time
technique,
hydrogel
properties
optimized,
avoiding
limitations
of
conventional
light
exposure.
These
gels
guide
blood-vessel
formation
in
vitro
promote
robust
microvessel
neural
development
vivo.
Precise
control
exposure
times
balances
cross-linking
fostering
vessel
growth
host
motor
neuron
ingrowth.
In
55%
VML,
enable
full-thickness
restoring
up
70%
lost
while
mimicking
healthy
tissue's
strength
structure.
Achieving
higher
degradation
rates
density
50
vessels/mm-2
is
essential
functional
strategies
effectively
bridge
current
clinical
gaps,
advancing
regenerative
medicine.
The
ability
fine-tune
stiffness
underscores
hydrogels'
potential
as
carriers,
allowing
the
reconstruction
at
injury
sites
significantly
enhancing
tissue
regeneration.
Язык: Английский
De Novo Amyloid Peptide–Polymer Blends with Enhanced Mechanical and Biological Properties
ACS Applied Polymer Materials,
Год журнала:
2025,
Номер
7(6), С. 3739 - 3751
Опубликована: Март 12, 2025
Amyloid
peptides
are
structurally
diverse
materials
that
exhibit
different
properties
depending
on
their
self-assembly.
While
they
often
associated
with
neurodegenerative
diseases,
functional
amyloids
play
important
roles
in
nature
and
high
relevance
for
biomedical
applications,
including
remarkable
strength,
mechanical
stability,
antimicrobial
antioxidant
properties,
low
cytotoxicity,
adhesion
to
biotic
abiotic
surfaces.
Challenges
developing
amyloid
biomaterials
include
the
complexity
of
peptide
chemistry
practical
techniques
required
processing
into
bulk
materials.
In
this
work,
two
de
novo
decapeptides
fibrillar
globular
morphologies
were
synthesized,
blended
poly(ethylene
oxide),
fabricated
composite
mats
via
electrospinning.
Notable
enhancements
observed,
attributed
uniform
distribution
assemblies
within
PEO
matrix
interactions
between
Morphological
differences,
such
as
production
thinner
nanofibers,
increased
conductivity
from
zwitterionic
decapeptides.
Blend
rheology
postprocessing
analysis
revealed
how
might
affect
aggregation
secondary
structure
peptides.
Both
demonstrated
cytotoxicity
strong
activity,
indicating
potential
safe
effective
use
biomaterials.
This
research
lays
foundation
designing
specific
applications
by
defining
structure-property-processing
relationships
peptide-polymer
blends.
Язык: Английский
A Biodegradable Shape Memory Polyurethane Film as a Postoperative Anti-adhesion Barrier for Minimally Invasive Surgery
Xiwan Wang,
Febyana Noor Fadlilah,
Qian Yang
и другие.
Acta Biomaterialia,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Amyloid peptide – synthetic polymer blends with enhanced mechanical and biological properties
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 30, 2024
ABSTRACT
Interest
in
utilizing
amyloids
to
develop
biomaterials
is
increasing
due
their
potential
for
biocompatibility,
unique
assembling
morphology,
mechanical
stability,
and
biophysical
properties.
However,
challenges
include
the
complexity
of
peptide
chemistry
practical
techniques
required
processing
into
bulk
materials.
In
this
work,
two
decapeptides
with
fibrillar
globular
morphologies
were
selected,
blended
poly(ethylene
oxide),
fabricated
composite
mats
via
electrospinning.
Notable
enhancements
properties
observed,
attributed
uniform
distribution
decapeptide
assemblies
within
PEO
matrix.
Morphological
differences,
such
as
production
thinner
nanofibers,
are
increased
conductivity
from
zwitterionic
nature
decapeptides.
Blend
rheology
post-processing
analysis
revealed
how
might
affect
amyloid
aggregation
secondary
structure
peptides.
Both
demonstrated
good
biocompatibility
strong
antioxidant
activity,
indicating
safe
effective
use
biomaterials.
By
evaluating
these
interdependencies,
research
lays
foundation
understanding
structure-property-processing
relationships
peptide-polymer
blends
highlights
developing
applications
biotechnology.
Язык: Английский
A “Janus” Zwitterionic Hydrogel Patch for Tissue Repair and Prevention of Post‐Operative Adhesions
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 6, 2024
Abstract
Anti‐peritoneal
adhesions
(PA)
are
very
important
after
abdominal
surgery
for
that
PA
often
leads
to
other
medical
problems
and
imposes
a
huge
financial
burden
on
the
national
healthcare
system.
In
this
work,
“Janus”
zwitterionic
hydrogel
patch
where
one
side
can
adhere
firmly
tissue,
while
has
anti‐fouling
properties
little
interaction
with
surrounding
tissue
been
developed.
The
is
prepared
by
in
situ
formation
of
bonding
polymer
layer
poly(acrylic‐co‐N‐hydroxysuccinimide
acrylate)
hydrogel.
mechanical,
swelling,
adhesion,
biodegradability
biocompatibility
tests
performed
study
function
prevent
wound
adhesion
rapid
repair.
It
found
adhesive
stable
tissues,
avoiding
slippage
faced
many
commercial
anti‐adhesion
gels
body.
resist
proteins
fibroblasts
external
interactions
or
tissues.
This
convenient
effective
method
provides
new
idea
design
postoperative
materials
broadens
application
hydrogels
biomedical
field.
Язык: Английский