Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown
Опубликована: Дек. 20, 2024
A schematic representation of preparation genetically modified dedifferentiated chondrocytes and porous double network hydrogels for their application in constructing tissue-engineered auricular cartilage scaffolds.
Язык: Английский
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101596 - 101596
Опубликована: Фев. 18, 2025
Язык: Английский
Процитировано
5
Gels, Год журнала: 2024, Номер 10(11), С. 703 - 703
Опубликована: Окт. 30, 2024
Hyaluronic acid (HA), an important natural polysaccharide and meanwhile, essential component of extracellular matrix (ECM), has been widely used in tissue repair regeneration due to its high biocompatibility, biodegradation, bioactivity, the versatile chemical groups for modification. Specially, HA-based dynamic hydrogels, compared with conventional offer adaptable network biomimetic microenvironment optimize process a striking resemblance ECM. Herein, this review comprehensively summarizes recent advances hydrogels focuses on their applications articular cartilage repair. First, fabrication methods advantages HA are presented. Then, illustrated from perspective cell-free cell-encapsulated and/or bioactive molecules (drugs, factors, ions). Finally, current challenges prospective directions outlined.
Язык: Английский
Процитировано
8
Biomimetics, Год журнала: 2024, Номер 9(7), С. 418 - 418
Опубликована: Июль 8, 2024
Biomimetic gels are synthetic materials designed to mimic the properties and functions of natural biological systems, such as tissues cellular environments. This manuscript explores advancements future directions injectable biomimetic in biomedical applications highlights significant potential hydrogels wound healing, tissue regeneration, controlled drug delivery due their enhanced biocompatibility, multifunctionality, mechanical properties. Despite these advancements, challenges resilience, degradation rates, scalable manufacturing remain. discusses ongoing research optimize properties, develop cost-effective production techniques, integrate emerging technologies like 3D bioprinting nanotechnology. Addressing through collaborative efforts is essential for unlocking full engineering regenerative medicine.
Язык: Английский
Процитировано
4
Frontiers in Chemistry, Год журнала: 2024, Номер 12
Опубликована: Ноя. 20, 2024
The extensive utilization of natural polymers in tissue engineering is attributed to their excellent biocompatibility, degradability, and resemblance the extracellular matrix. These have a wide range applications such as delivering therapeutic medicine, detecting diseases, sensing biological substances, promoting regeneration, treating diseases. This brief review current developments properties uses widely used biomedical derived from nature. Additionally, it explores correlation between characteristics functions these materials different highlights prospective direction for advancement polymer engineering.
Язык: Английский
Процитировано
4
Chem & Bio Engineering, Год журнала: 2024, Номер 1(11), С. 916 - 933
Опубликована: Окт. 8, 2024
The extracellular matrix (ECM) performs both as a static scaffold and dynamic, viscoelastic milieu that actively participates in cell signaling mechanical feedback loops. Recently, biomaterials with tunable properties have been utilized to mimic the native ECM fields of tissue engineering regenerative medicines. These materials can be designed support attachment, proliferation, differentiation, facilitating repair or replacement damaged tissues. Moreover, viscoelasticity modulation mimicry helps develop therapeutic strategies for diseases involving altered tissues such fibrosis cancer. study biomaterial thus intersects broad spectrum biological medical disciplines, offering insights into fundamental biology practical solutions improving human health. This review delves design fabrication hydrogels, focusing particularly on two major parameters, strength stress relaxation, how hydrogel mechanics influence interactions between living cells surrounding microenvironments. Meanwhile, this discusses current bottlenecks hydrogel-cell studies, highlighting challenges parameter decoupling, long-term stable maintenance microenvironment, general applicability testing standards conversion protocols.
Язык: Английский
Процитировано
3
Carbohydrate Polymer Technologies and Applications, Год журнала: 2025, Номер unknown, С. 100815 - 100815
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
MedComm, Год журнала: 2025, Номер 6(5)
Опубликована: Апрель 24, 2025
ABSTRACT Hydrogels have emerged as dependable candidates for tissue repair because of their exceptional biocompatibility and tunable mechanical properties. However, conventional hydrogels are vulnerable to damage owing stress environmental factors that compromise structural integrity reduce lifespan. In contrast, self‐healing with inherent ability restore structure function autonomously offer prolonged efficacy enhanced appeal. These can be engineered into innovative forms including stimulus‐responsive, self‐degradable, injectable, drug‐loaded variants, thereby enhancing applicability in wound healing, drug delivery, engineering. This review summarizes the categories mechanisms hydrogels, along biomedical applications, repair, biosensing. Tissue includes bone‐related nerve cardiac repair. Additionally, we explored challenges continue face presented a forward‐looking perspective on development. Consequently, it is anticipated will progressively designed developed applications extend beyond broader range applications.
Язык: Английский
Процитировано
0
Journal of Bionic Engineering, Год журнала: 2025, Номер unknown
Опубликована: Апрель 25, 2025
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Май 26, 2025
Repairing chondral defects remains challenging due to the avascular and acellular nature of cartilage. Advances in tissue engineering based on hydrogels offer significant potential for high-quality chondrogenesis, with injectable emerging as a prominent area research, because they meet requirements minimally invasive administration. This review provides an overview recent progress cartilage repair regeneration summarizes synthesis strategies. We specifically focused key challenges including gelation techniques, robust bioadhesion, bioactive functionalization, which are primary obstacles achieving superior studies. By exploring current strategies address these their underlying mechanism, we aim inspire continuous advancements promoting application regeneration.
Язык: Английский
Процитировано
0
Journal of Colloid and Interface Science, Год журнала: 2024, Номер 683, С. 828 - 844
Опубликована: Дек. 26, 2024
Язык: Английский
Процитировано
1