Cited by Double Network Hydrogels Encapsulating Genetically Modified Dedifferentiated Chondrocytes for Auricular Cartilage Regeneration

Hyaluronic acid as a versatile building block for the development of biofunctional hydrogels: in vitro models and preclinical innovations DOI

Noémie Petit,

Yu-Ming Chang,

Franz Acker Lobianco

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101596 - 101596

Published: Feb. 18, 2025

Language: Английский

Citations

Hyaluronic Acid-Based Dynamic Hydrogels for Cartilage Repair and Regeneration DOI

Mingshuo Zhang,

Qianwen Ye, Zhanghua Zhu

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 703 - 703

Published: Oct. 30, 2024

Hyaluronic acid (HA), an important natural polysaccharide and meanwhile, essential component of extracellular matrix (ECM), has been widely used in tissue repair regeneration due to its high biocompatibility, biodegradation, bioactivity, the versatile chemical groups for modification. Specially, HA-based dynamic hydrogels, compared with conventional offer adaptable network biomimetic microenvironment optimize process a striking resemblance ECM. Herein, this review comprehensively summarizes recent advances hydrogels focuses on their applications articular cartilage repair. First, fabrication methods advantages HA are presented. Then, illustrated from perspective cell-free cell-encapsulated and/or bioactive molecules (drugs, factors, ions). Finally, current challenges prospective directions outlined.

Language: Английский

Citations

Advances of naturally derived biomedical polymers in tissue engineering DOI

Tao Hu, Jie Fang,

Yang Shen

et al.

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 20, 2024

The extensive utilization of natural polymers in tissue engineering is attributed to their excellent biocompatibility, degradability, and resemblance the extracellular matrix. These have a wide range applications such as delivering therapeutic medicine, detecting diseases, sensing biological substances, promoting regeneration, treating diseases. This brief review current developments properties uses widely used biomedical derived from nature. Additionally, it explores correlation between characteristics functions these materials different highlights prospective direction for advancement polymer engineering.

Language: Английский

Citations

Modeling of Molecular Weight Changes of Polysaccharides Subjected to Irradiation DOI

Li Wang,

Peiling Huang,

Jianyong Huang

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100815 - 100815

Published: April 1, 2025

Language: Английский

Citations

Self‐Healing Hydrogels: Mechanisms and Biomedical Applications DOI

Lingling Xue,

Ran An,

Junqi Zhao

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(5)

Published: April 24, 2025

ABSTRACT Hydrogels have emerged as dependable candidates for tissue repair because of their exceptional biocompatibility and tunable mechanical properties. However, conventional hydrogels are vulnerable to damage owing stress environmental factors that compromise structural integrity reduce lifespan. In contrast, self‐healing with inherent ability restore structure function autonomously offer prolonged efficacy enhanced appeal. These can be engineered into innovative forms including stimulus‐responsive, self‐degradable, injectable, drug‐loaded variants, thereby enhancing applicability in wound healing, drug delivery, engineering. This review summarizes the categories mechanisms hydrogels, along biomedical applications, repair, biosensing. Tissue includes bone‐related nerve cardiac repair. Additionally, we explored challenges continue face presented a forward‐looking perspective on development. Consequently, it is anticipated will progressively designed developed applications extend beyond broader range applications.

Language: Английский

Citations

Current Status of Research on Biomimetic Hydrogels for Articular Cartilage DOI

Kuishun Ma,

Fei Wang,

Tingxin Liang

et al.

Journal of Bionic Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

Citations

Injectable Biomimetic Gels for Biomedical Applications DOI

Hossein Omidian,

Renae L. Wilson,

Sumana Dey Chowdhury

et al.

Biomimetics, Journal Year: 2024, Volume and Issue: 9(7), P. 418 - 418

Published: July 8, 2024

Biomimetic gels are synthetic materials designed to mimic the properties and functions of natural biological systems, such as tissues cellular environments. This manuscript explores advancements future directions injectable biomimetic in biomedical applications highlights significant potential hydrogels wound healing, tissue regeneration, controlled drug delivery due their enhanced biocompatibility, multifunctionality, mechanical properties. Despite these advancements, challenges resilience, degradation rates, scalable manufacturing remain. discusses ongoing research optimize properties, develop cost-effective production techniques, integrate emerging technologies like 3D bioprinting nanotechnology. Addressing through collaborative efforts is essential for unlocking full engineering regenerative medicine.

Language: Английский

Citations

Design and Fabrication of Viscoelastic Hydrogels as Extracellular Matrix Mimicry for Cell Engineering DOI

Zi-Yuan Li,

Tianyue Li,

Hao-Chen Yang

et al.

Chem & Bio Engineering, Journal Year: 2024, Volume and Issue: 1(11), P. 916 - 933

Published: Oct. 8, 2024

The extracellular matrix (ECM) performs both as a static scaffold and dynamic, viscoelastic milieu that actively participates in cell signaling mechanical feedback loops. Recently, biomaterials with tunable properties have been utilized to mimic the native ECM fields of tissue engineering regenerative medicines. These materials can be designed support attachment, proliferation, differentiation, facilitating repair or replacement damaged tissues. Moreover, viscoelasticity modulation mimicry helps develop therapeutic strategies for diseases involving altered tissues such fibrosis cancer. study biomaterial thus intersects broad spectrum biological medical disciplines, offering insights into fundamental biology practical solutions improving human health. This review delves design fabrication hydrogels, focusing particularly on two major parameters, strength stress relaxation, how hydrogel mechanics influence interactions between living cells surrounding microenvironments. Meanwhile, this discusses current bottlenecks hydrogel-cell studies, highlighting challenges parameter decoupling, long-term stable maintenance microenvironment, general applicability testing standards conversion protocols.

Language: Английский

Citations

Multi-crosslinking nanoclay/oxidized cellulose hydrogel bandage with robust mechanical strength, antibacterial and adhesive properties for emergency hemostasis DOI

Tiange Zhao,

Ruyi Ren,

Sheng Ru Qiao

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 683, P. 828 - 844

Published: Dec. 26, 2024

Language: Английский

Citations

Double Network Hydrogels Encapsulating Genetically Modified Dedifferentiated Chondrocytes for Auricular Cartilage Regeneration DOI

Yang Liu, Xiaoting Chen,

Tan Xue-qin

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

A schematic representation of preparation genetically modified dedifferentiated chondrocytes and porous double network hydrogels for their application in constructing tissue-engineered auricular cartilage scaffolds.

Language: Английский

Citations