Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Сен. 4, 2024
Although guidelines support the efficacy of Modified Qing' E Formula (MQEF) in treating postmenopausal osteoporosis (PMOP), its underlying mechanisms remain incompletely understood. This retrospective investigation aims to elucidate MQEF's impact on serum exosomal miRNA expression patients and explore potential therapeutic mechanisms.
Язык: Английский
Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13
Опубликована: Март 27, 2025
Osteoarthritis (OA) and type 2 diabetes mellitus (T2DM) often coexist due to shared risk factors high prevalence, but effective treatment methods are currently lacking. Mesenchymal stromal/stem cell-derived exosomes (MSC-Exos) have regenerative properties that can repair cartilage damage, lower blood sugar levels, improve pancreatic β cell function, showing great potential in tissue repair. This review primarily explores the application of MSC-Exos OA T2DM, mechanisms MSC-Exos, therapeutic strategies engineered exosomes. Although MSC-Exo therapy shows promising potential, further research is needed validate its safety feasibility.
Язык: Английский
Процитировано
0
Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)
Опубликована: Апрель 11, 2025
Язык: Английский
Процитировано
0
Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)
Опубликована: Ноя. 9, 2024
Bone regeneration is a complex biological process that relies on the orchestrated interplay of various cellular and molecular events. tissue engineering currently most promising method for treating bone regeneration. However, immunogenicity, stable cell quantity seed cells limited their application. Recently, exosomes, which are small extracellular vesicles released by cells, have been found to effectively address these problems better induce Meanwhile, growing line research has shown cargos exosomes may provide effective therapeutic biomarker tools repair, including miRNA, lncRNA, proteins. Moreover, engineered scaffolds loaded with can offer cell-free repair strategy, addressing immunogenicity concerns providing more functional performance. Herein, we comprehensive summary role played in regeneration, drawing systematic analysis relevant literature available PubMed, Scopus, Google Scholar database.
Язык: Английский
Процитировано
3
MedComm – Biomaterials and Applications, Год журнала: 2024, Номер 3(3)
Опубликована: Сен. 1, 2024
Abstract The rapid evolution of clinical medicine, materials science, and regenerative medicine has rendered traditional implantable scaffolds inadequate for addressing the complex therapeutic demands various diseases. Currently, in practice are mainly made metal, with disadvantages high stiffness, poor toughness, low deformation. This paper offers a thorough review shape memory (SMSs), emphasizing their distinctive self‐recovery adaptive functionalities that enhance compatibility injured tissues, surpassing capabilities conventional metallic biomaterials. It delves into limitations current requisite performance metrics effective implants outlines essential fabrication methods SMSs. Moreover, we enumerate biomedical applications SMMs different response types, including thermology‐responsive, water‐responsive, light‐responsive. discussion extends to burgeoning SMSs engineering, utility bone tissue cardiovascular stenting, tubular structures, cardiac patches, which underscore potential minimally invasive procedures dynamic interactions. concludes an analysis challenges prospects, providing valuable insights developing applying sector.
Язык: Английский
Процитировано
1
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 29, 2024
Abstract Persistent luminescence nanoparticles (PLNPs) can achieve autofluorescence‐free afterglow imaging, while near‐infrared (NIR) emission realizes deep tissue imaging. Nanozymes integrate the merits of nanomaterials and enzyme‐mimicking activities with simple preparation. Here PLNPs are prepared Zn 1.2 Ga 1.6 Ge 0.2 O 4 :Cr 0.0075 NIR at 700 nm. The then incubated IrCl 3 solution, collected annealed 750 °C to obtain iridium@PLNPs. Iridium is observed on atomic level as a single‐atom nanozyme peroxidase‐like catalytic activity, photothermal conversion, computed tomography (CT) contrast capability. After coating exosome membrane (EM), Ir@PLNPs@EM composite exhibits long‐lasting luminescence, CT capability, targeting capability biocompatibility from EM. Thus, afterglow/photothermal/CT trimodal imaging‐guided photothermal‐chemodynamic combination therapy realized validated in vitro vivo inhibition tumor growth, toxicity side effects avoided drug‐free treatment. This work offers promising avenue for advanced nanozyme@PLNPs promote development nanozymes clinical applications.
Язык: Английский
Процитировано
1
Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)
Опубликована: Окт. 19, 2024
Язык: Английский
Процитировано
1
Biomolecules, Год журнала: 2024, Номер 14(12), С. 1519 - 1519
Опубликована: Ноя. 27, 2024
Exosomes, nano-sized lipid bilayer vesicles, have garnered significant attention as mediators of cell communication, particularly within the central nervous system (CNS). Their unique properties, including high stability, low immunogenicity, and ability to traverse blood-brain barrier (BBB), position them promising tools for understanding addressing CNS diseases. This comprehensive review delves into biogenesis, composition, functions, isolation exosomes, with a particular focus on their roles in cerebrovascular diseases, neurodegenerative disorders, tumors. Exosomes are involved key pathophysiological processes CNS, angiogenesis, inflammation, apoptosis, cellular microenvironment modification. They demonstrate promise mitigating ischemic injury, regulating inflammatory responses, providing neuroprotection across various conditions. Furthermore, exosomes carry distinct biomolecules, offering novel method early diagnosis monitoring Despite potential, challenges such complex extraction processes, heterogeneity exosomal contents, targeted delivery limitations hinder clinical application. Nevertheless, hold advancing our diseases developing therapeutic strategies. manuscript significantly contributes field by highlighting exosomes’ potential underscoring value strategies mediating communication.
Язык: Английский
Процитировано
1
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Сен. 4, 2024
Although guidelines support the efficacy of Modified Qing' E Formula (MQEF) in treating postmenopausal osteoporosis (PMOP), its underlying mechanisms remain incompletely understood. This retrospective investigation aims to elucidate MQEF's impact on serum exosomal miRNA expression patients and explore potential therapeutic mechanisms.
Язык: Английский
Процитировано
0