Mesenchymal stem cell exosomes therapy for the treatment of traumatic brain injury: mechanism, progress, challenges and prospects
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 11, 2025
Язык: Английский
Exosomes to exosome-functionalized scaffolds: a novel approach to stimulate bone regeneration
Stem Cell Research & Therapy,
Год журнала:
2024,
Номер
15(1)
Опубликована: Ноя. 9, 2024
Bone
regeneration
is
a
complex
biological
process
that
relies
on
the
orchestrated
interplay
of
various
cellular
and
molecular
events.
tissue
engineering
currently
most
promising
method
for
treating
bone
regeneration.
However,
immunogenicity,
stable
cell
quantity
seed
cells
limited
their
application.
Recently,
exosomes,
which
are
small
extracellular
vesicles
released
by
cells,
have
been
found
to
effectively
address
these
problems
better
induce
Meanwhile,
growing
line
research
has
shown
cargos
exosomes
may
provide
effective
therapeutic
biomarker
tools
repair,
including
miRNA,
lncRNA,
proteins.
Moreover,
engineered
scaffolds
loaded
with
can
offer
cell-free
repair
strategy,
addressing
immunogenicity
concerns
providing
more
functional
performance.
Herein,
we
comprehensive
summary
role
played
in
regeneration,
drawing
systematic
analysis
relevant
literature
available
PubMed,
Scopus,
Google
Scholar
database.
Язык: Английский
Mesenchymal stromal/stem cell-derived exosomes as a potential therapeutic approach to osteoarthritis combined with type 2 diabetes mellitus
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Март 27, 2025
Osteoarthritis
(OA)
and
type
2
diabetes
mellitus
(T2DM)
often
coexist
due
to
shared
risk
factors
high
prevalence,
but
effective
treatment
methods
are
currently
lacking.
Mesenchymal
stromal/stem
cell-derived
exosomes
(MSC-Exos)
have
regenerative
properties
that
can
repair
cartilage
damage,
lower
blood
sugar
levels,
improve
pancreatic
β
cell
function,
showing
great
potential
in
tissue
repair.
This
review
primarily
explores
the
application
of
MSC-Exos
OA
T2DM,
mechanisms
MSC-Exos,
therapeutic
strategies
engineered
exosomes.
Although
MSC-Exo
therapy
shows
promising
potential,
further
research
is
needed
validate
its
safety
feasibility.
Язык: Английский
The extracellular vesicle-based treatment: a developing strategy for periodontal diseases
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Май 29, 2025
Periodontitis,
a
chronic
inflammatory
disease,
is
characterized
by
irreversible
bone
resorption,
persistent
attachment
loss,
and
even
ultimate
tooth
loss.
The
individual
quality
of
life
the
public
burden
health
are
greatly
impacted
destruction
periodontal
tissue
lack
effective
treatment.
Exploration
into
how
damaged
structure
changes
healthy
regenerative
one
most
fascinating
subjects
in
this
field.
A
novel
approach
application
nanoparticle,
extracellular
vesicle,
which
originates
from
natural
or
engineered
cells.
To
further
exploit
its
full
potential,
scientists
have
conducted
massive
studies
biological
functional
mechanisms.
This
review
provides
an
overview
current
vesicle-based
treatments
on
diseases.
It
begins
with
summarizing
history
regeneration.
Then,
article
takes
general
vesicle’s
characteristics,
structures
achievements.
After
that,
we
discussed
functions
periodontium.
In
addition,
study
also
embraces
diverse
range
strategies,
workflow
for
EVs’
application.
Finally,
challenges
prospects
extracellular-based
therapy
been
discussed.
Язык: Английский
Sea buckthorn-derived extracellular vesicles foster bone regeneration through aau-miR168-mediated pathways
Stem Cell Research & Therapy,
Год журнала:
2025,
Номер
16(1)
Опубликована: Июнь 3, 2025
Plant-derived
extracellular
vesicles
(P-EVs)
possess
remarkable
therapeutic
potential,
yet
the
regenerative
capabilities
of
sea
buckthorn-derived
(SAEVs)
remain
underexplored.
This
study
aims
to
elucidate
osteogenic
and
bone-healing
properties
SAEVs.
SAEVs
were
isolated
from
buckthorn
juice
via
differential
centrifugation
characterized
using
electron
microscopy
dynamic
light
scattering.
Bone
marrow
mesenchymal
stromal
cells
(BMSCs)
treated
with
SAEVs,
cellular
uptake
was
evaluated
through
fluorescence
flow
cytometry.
In
vivo,
DiD-labeled
orally
administered
mice
determine
biodistribution
IVIS
imaging.
A
murine
femoral
defect
model
employed
assess
bone
efficacy
delivered
or
without
GelMA
hydrogels,
analyzed
by
micro-CT
histological
staining.
Small
RNA
sequencing
identified
SAEV-derived
miRNAs,
luciferase
reporter
assays
validated
miRNA-mediated
regulation
genes.
efficiently
internalized
into
BMSCs
macropinocytosis,
promoting
expression
key
markers
such
as
Runx2
osteocalcin.
SAEV-GelMA
hydrogels
significantly
accelerated
regeneration
in
a
inducing
adverse
hematological
effects,
affirming
safety
SAEV
administration.
Mechanistic
investigations
revealed
an
enrichment
particularly
aau-miR168,
which
modulates
osteogenesis
aau-miR168/LBH/RUNX2
signaling
cascade.
highlights
transformative
biocompatible
strategy
for
fracture
healing
osteoporosis
management,
offering
novel
avenue
medicine.
Язык: Английский
The influence of modified Qing E Formula on the differential expression of serum exosomal miRNAs in postmenopausal osteoporosis patients
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 4, 2024
Although
guidelines
support
the
efficacy
of
Modified
Qing'
E
Formula
(MQEF)
in
treating
postmenopausal
osteoporosis
(PMOP),
its
underlying
mechanisms
remain
incompletely
understood.
This
retrospective
investigation
aims
to
elucidate
MQEF's
impact
on
serum
exosomal
miRNA
expression
patients
and
explore
potential
therapeutic
mechanisms.
Язык: Английский
Current status and challenges of shape memory scaffolds in biomedical applications
MedComm – Biomaterials and Applications,
Год журнала:
2024,
Номер
3(3)
Опубликована: Сен. 1, 2024
Abstract
The
rapid
evolution
of
clinical
medicine,
materials
science,
and
regenerative
medicine
has
rendered
traditional
implantable
scaffolds
inadequate
for
addressing
the
complex
therapeutic
demands
various
diseases.
Currently,
in
practice
are
mainly
made
metal,
with
disadvantages
high
stiffness,
poor
toughness,
low
deformation.
This
paper
offers
a
thorough
review
shape
memory
(SMSs),
emphasizing
their
distinctive
self‐recovery
adaptive
functionalities
that
enhance
compatibility
injured
tissues,
surpassing
capabilities
conventional
metallic
biomaterials.
It
delves
into
limitations
current
requisite
performance
metrics
effective
implants
outlines
essential
fabrication
methods
SMSs.
Moreover,
we
enumerate
biomedical
applications
SMMs
different
response
types,
including
thermology‐responsive,
water‐responsive,
light‐responsive.
discussion
extends
to
burgeoning
SMSs
engineering,
utility
bone
tissue
cardiovascular
stenting,
tubular
structures,
cardiac
patches,
which
underscore
potential
minimally
invasive
procedures
dynamic
interactions.
concludes
an
analysis
challenges
prospects,
providing
valuable
insights
developing
applying
sector.
Язык: Английский
Single‐Atom Iridium Nanozyme‐Based Persistent Luminescence Nanoparticles for Multimodal Imaging‐Guided Combination Tumor Therapy
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 29, 2024
Abstract
Persistent
luminescence
nanoparticles
(PLNPs)
can
achieve
autofluorescence‐free
afterglow
imaging,
while
near‐infrared
(NIR)
emission
realizes
deep
tissue
imaging.
Nanozymes
integrate
the
merits
of
nanomaterials
and
enzyme‐mimicking
activities
with
simple
preparation.
Here
PLNPs
are
prepared
Zn
1.2
Ga
1.6
Ge
0.2
O
4
:Cr
0.0075
NIR
at
700
nm.
The
then
incubated
IrCl
3
solution,
collected
annealed
750
°C
to
obtain
iridium@PLNPs.
Iridium
is
observed
on
atomic
level
as
a
single‐atom
nanozyme
peroxidase‐like
catalytic
activity,
photothermal
conversion,
computed
tomography
(CT)
contrast
capability.
After
coating
exosome
membrane
(EM),
Ir@PLNPs@EM
composite
exhibits
long‐lasting
luminescence,
CT
capability,
targeting
capability
biocompatibility
from
EM.
Thus,
afterglow/photothermal/CT
trimodal
imaging‐guided
photothermal‐chemodynamic
combination
therapy
realized
validated
in
vitro
vivo
inhibition
tumor
growth,
toxicity
side
effects
avoided
drug‐free
treatment.
This
work
offers
promising
avenue
for
advanced
nanozyme@PLNPs
promote
development
nanozymes
clinical
applications.
Язык: Английский
The role of biophysical cues and their modulated exosomes in dental diseases: from mechanism to therapy
Stem Cell Research & Therapy,
Год журнала:
2024,
Номер
15(1)
Опубликована: Окт. 19, 2024
Язык: Английский
Exosomes in Central Nervous System Diseases: A Comprehensive Review of Emerging Research and Clinical Frontiers
Biomolecules,
Год журнала:
2024,
Номер
14(12), С. 1519 - 1519
Опубликована: Ноя. 27, 2024
Exosomes,
nano-sized
lipid
bilayer
vesicles,
have
garnered
significant
attention
as
mediators
of
cell
communication,
particularly
within
the
central
nervous
system
(CNS).
Their
unique
properties,
including
high
stability,
low
immunogenicity,
and
ability
to
traverse
blood-brain
barrier
(BBB),
position
them
promising
tools
for
understanding
addressing
CNS
diseases.
This
comprehensive
review
delves
into
biogenesis,
composition,
functions,
isolation
exosomes,
with
a
particular
focus
on
their
roles
in
cerebrovascular
diseases,
neurodegenerative
disorders,
tumors.
Exosomes
are
involved
key
pathophysiological
processes
CNS,
angiogenesis,
inflammation,
apoptosis,
cellular
microenvironment
modification.
They
demonstrate
promise
mitigating
ischemic
injury,
regulating
inflammatory
responses,
providing
neuroprotection
across
various
conditions.
Furthermore,
exosomes
carry
distinct
biomolecules,
offering
novel
method
early
diagnosis
monitoring
Despite
potential,
challenges
such
complex
extraction
processes,
heterogeneity
exosomal
contents,
targeted
delivery
limitations
hinder
clinical
application.
Nevertheless,
hold
advancing
our
diseases
developing
therapeutic
strategies.
manuscript
significantly
contributes
field
by
highlighting
exosomes’
potential
underscoring
value
strategies
mediating
communication.
Язык: Английский