Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 6, 2024
Abstract
Bone
marrow
stem
cells
(BMSCs)‐engineered
cartilage
(BEC)
shows
promise
for
clinically
repairing
defects.
However,
when
implanted
in
immunocompetent
large
animals,
BEC
becomes
susceptible
to
ossification
due
inflammatory
infiltration.
To
address
this,
a
nanofilm
isolation
approach
is
developed
enhance
BEC's
chondrogenic
stability.
Tacrolimus
(FK506),
known
its
immunosuppressive
effect,
integrated
into
adipic
dihydrazide
(ADH)‐modified
hyaluronic
acid
(HA),
creating
an
acid‐responsive
macromolecular
prodrug
called
FK506@HA‐ADH.
This
then
blended
with
poly(lactic‐co‐glycolic
acid)
(PLGA)
form
electrospun
FK506@HA/PLGA
nanofilm.
Goat‐derived
BMSCs
are
induced
vitro
BEC,
which
enclosed
within
the
and
subcutaneously
autologous
goats.
The
acted
as
physical
barrier,
preventing
immunocyte
Additionally,
response
acidic
environment
triggered
by
inflammation
gradual
degradation
of
PLGA,
FK506@HA‐ADH
cleaved,
releasing
FK506
needed.
released
effectively
countered
cytokines
promoted
cartilaginous
maturity.
These
combined
mechanisms
significantly
inhibited
hypertrophy
improved
stability
goat
model.
nanofilm‐based
strategy
established
niche,
successfully
endochondral
promoting
stable
formation
BEC.
advancements
crucial
translating
cell‐based
therapies
clinical
use
repair.
Journal of Polymer Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
ABSTRACT
Skin
defects
caused
by
injuries
such
as
burns
that
exceed
a
certain
diameter
no
longer
heal
spontaneously
and
require
more
complex
interventions.
Hydrogels
have
received
special
attention
due
to
their
unique
ability
block
the
penetration
of
bacteria
into
wounds
they
can
absorb
contaminated
exudates
exhibit
high
degree
flexibility.
This
study
is
focused
on
preparation
characterization
novel
antibacterial
biocomposite
hydrogels
based
two
carbohydrates,
alginate
hyaluronic
acid
(HA),
with
immobilized
ZnO
NPs
curcumin‐loaded
electrospun
nanofibers
improve
efficacy
wound
healing
process.
The
hydrogel
matrix
was
obtained
after
crosslinking
HA
in
presence
DMT‐MM
activator.
were
physicochemically
characterized
FT‐IR,
scanning
electron
microscopy
(SEM),
UV–Vis
spectroscopy,
swelling
also
investigated.
It
appeared
behavior
influenced
amount
nanofibers.
Biodegradability,
hemolysis,
cell
viability,
antimicrobial,
vitro
irritability
tests
carried
out
assess
biological
properties.
results
highlighted
these
are
biodegradable,
hemocompatible,
non‐cytotoxic,
non‐irritating
good
antimicrobial
activity.
Based
results,
materials
might
be
interesting
candidates
for
treatment.
ACS Omega,
Год журнала:
2025,
Номер
10(13), С. 13570 - 13582
Опубликована: Март 27, 2025
Tissue-engineered
cartilage,
supported
by
advancements
in
photo-cross-linkable
hydrogels,
offers
a
promising
solution
for
the
repair
and
regeneration
of
damaged
cartilage
anatomically
complex
mechanically
demanding
sites.
Low-temperature
soluble
GelMA
(LT-GelMA)
remains
liquid
state
at
room
temperature,
allowing
easier
handling;
however,
it
has
limitations
mechanical
strength
structural
stability.
To
address
these
limitations,
we
developed
novel
dual-network
hydrogel
combining
LT-GelMA
with
Pluronic
F127-diacrylate
(F127DA).
The
resulting
uniquely
integrates
low-temperature
solubility
enhanced
provided
F127DA
nanomicelles.
Additionally,
exhibits
controlled
swelling
biodegradation
rates.
In
vitro
studies
revealed
significant
increase
chondrocyte
viability
day
7
formulations
higher
concentrations.
vivo,
demonstrated
superior
neo-cartilage
formation
subcutaneous
nude
mouse
model,
as
indicated
increased
deposition
cartilage-specific
extracellular
matrix
components
4
8
weeks.
summary,
fluidity
temperature
performance.
These
results
indicate
that
LT-GelMA/F127DA
effectively
addresses
current
gaps
tissue
engineering.
hydrogel's
performance,
especially
promoting
regeneration,
positions
alternative
reconstructive
surgery,
representing
improvement
over
existing
strategies.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 30, 2024
Abstract
Mechanical
force
is
essential
for
bone
development,
homeostasis,
and
fracture
healing.
In
the
past
few
decades,
various
biomaterials
have
been
developed
to
provide
mechanical
signals
that
mimic
natural
microenvironment,
thereby
promoting
regeneration.
Bone
organoids,
emerging
as
a
novel
research
approach,
are
3D
micro‐bone
tissues
possess
ability
self‐renew
self‐organize,
exhibiting
biomimetic
spatial
characteristics.
Incorporating
mechano‐responsive
in
construction
of
organoids
presents
promising
avenue
simulating
microenvironment.
Therefore,
this
review
commences
by
elucidating
impact
on
health,
encompassing
both
cellular
interactions
alterations
structure.
Furthermore,
most
recent
applications
within
realm
tissue
engineering
highlighted.
Three
different
types
introduced
with
focus
their
responsive
mechanisms,
strategies,
efficacy
facilitating
Based
comprehensive
overview,
prospective
utilization
future
challenges
discussed.
As
organoid
technology
advances,
these
poised
become
powerful
tools
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 30, 2024
Abstract
Large
segmental
bone
defects
often
lead
to
nonunion
and
dysfunction,
posing
a
significant
challenge
for
clinicians.
Inspired
by
the
intrinsic
defect
repair
logic
of
“vascularization
then
osteogenesis”,
this
study
originally
reports
smart
implantable
hydrogel
(PDS‐DC)
with
high
mechanical
properties,
controllable
scaffold
degradation,
timing
drug
release
that
can
proactively
match
different
healing
cycles
efficiently
promote
regeneration.
The
main
PDS‐DC
consists
polyacrylamide,
polydopamine,
silk
fibroin,
which
endows
it
superior
interfacial
adhesion,
structural
toughness,
stiffness.
In
particular,
adjustment
cross‐linking
agent
mixing
ratio
effectively
regulate
in
vivo
degradation
rate
intelligently
satisfy
requirements
cycles.
Ultimately,
PDS
loaded
free
desferrioxamine
(DFO)
CaCO
3
mineralized
ZIF‐90
morphogenetic
protein‐2
(BMP‐2)
stimulate
efficient
angiogenesis
osteogenesis.
Notably,
DFO
is
released
rapidly
diffusion,
whereas
BMP‐2
slowly
pH‐dependent
layer‐by‐layer
disintegration,
resulting
difference
time,
thus
matching
repair.
vitro
results
confirm
realize
high‐quality
generation
adapt
demands
defects.
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2024,
Номер
unknown, С. 1 - 23
Опубликована: Окт. 10, 2024
Damage
to
articular
cartilage
is
irreversible
and
its
ability
heal
minimal.
The
development
of
in
tissue
engineering
requires
suitable
biomaterials
as
scaffolds
that
provide
a
3D
natural
microenvironment
for
the
growth
cartilage.
This
study
aims
investigate
applicability
printed
CSH
(collagen
type
II/silk
fibroin/hyaluronic
acid)
scaffold
constructing
engineering.
results
showed
composite
had
three-dimensional
porous
network
structure
with
uniform
pore
sizes
good
connectivity.
hydrophilicity
was
1071.7
±
131.6%,
porosity
85.12
1.6%,
compressive
elastic
modulus
36.54
2.28
kPa.
creep
stress
relaxation
constitutive
models
were
also
established,
which
could
well
describe
visco-elastic
mechanical
behavior
scaffold.
biocompatibility
experiments
very
adhesion
proliferation
chondrocytes.
Under
dynamic
loading
conditions,
it
able
promote
cell
on
surface.
expected
be
ideal
promoting
regeneration.
