Nanomaterials evoke pyroptosis boosting cancer immunotherapy DOI Creative Commons
Zhenhua Li,

Ziyue Xi,

Chuanyong Fan

и другие.

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 15(2), С. 852 - 875

Опубликована: Ноя. 23, 2024

Cancer immunotherapy is currently a very promising therapeutic strategy for treating tumors. However, its effectiveness restricted by insufficient antigenicity and an immunosuppressive tumor microenvironment (ITME). Pyroptosis, unique form of programmed cell death (PCD), causes cells to swell rupture, releasing pro-inflammatory factors that can enhance immunogenicity remodel the ITME. Nanomaterials, with their distinct advantages different techniques, are increasingly popular, nanomaterial-based delivery systems demonstrate significant potential potentiate, enable, augment pyroptosis. This review summarizes discusses emerging field nanomaterials-induced pyroptosis, focusing on mechanisms pyroptosis pathways strategies activate or specific Additionally, we provide perspectives development this field, aiming accelerate further clinical transition.

Язык: Английский

Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication DOI Creative Commons
Hua Wang, Tao Wang, Shuxiang Yan

и другие.

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Ноя. 30, 2024

In the realm of cancer research, tumor microenvironment (TME) plays a crucial role in initiation and progression, shaped by complex interactions between cells surrounding non-cancerous cells. Cytokines, as essential immunomodulatory agents, are secreted various cellular constituents within TME, including immune cells, cancer-associated fibroblasts, themselves. These cytokines facilitate intricate communication networks that significantly influence initiation, metastasis, suppression. Pyroptosis contributes to TME remodeling promoting release pro-inflammatory sustaining chronic inflammation, impacting processes such escape angiogenesis. However, challenges remain due interplay among cytokines, pyroptosis, along with dual effects pyroptosis on progression therapy-related complications like cytokine syndrome. Unraveling these complexities could strategies balance inflammatory responses while minimizing tissue damage during therapy. This review delves into crosstalk elucidating their contribution metastasis. By synthesizing emerging therapeutic targets innovative technologies concerning this aims provide novel insights enhance treatment outcomes for patients.

Язык: Английский

Процитировано

15

Manipulating the cGAS-STING Axis: advancing innovative strategies for osteosarcoma therapeutics DOI Creative Commons
Bingbing Li, Cheng Zhang,

Xiao-juan Xu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 7, 2025

This paper explored the novel approach of targeting cyclic guanosine monophosphate (GMP)-adenosine (AMP) synthase-stimulator interferon genes (cGAS-STING) pathway for treatment osteosarcoma (OS). Osteosarcoma is a common malignancy in adolescents. Most patients die from lung metastasis. It reviewed epidemiology and pathological characteristics OS, highlighting its highly malignant nature tendency pulmonary metastasis, underscoring importance identifying new therapeutic targets. The cGAS-STING was closely associated with biological behaviors OS cells, suggesting that this could be promising strategy. Currently, research on role has been limited, underlying mechanisms remain unclear. Therefore, further investigation into exploration strategies based are great significance developing more effective treatments OS. offered fresh perspective providing hope options by pathway.

Язык: Английский

Процитировано

1

An Injectable Multifunctional Nanosweeper Eliminates Cardiac Mitochondrial DNA to Reduce Inflammation DOI Open Access

Yi‐Jing Li,

Xiumeng Hua, Yahui Zhao

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Myocarditis, a leading cause of sudden cardiac death and heart transplantation, poses significant treatment challenges. The study clinical samples from myocarditis patients reveals correlation between the pathogenesis cardiomyocyte mitochondrial DNA (mtDNA). During inflammation, concentration mtDNA in cardiomyocytes increases. Hence, it is hypothesized that combined clearance its downstream STING pathway can treat myocarditis. However, clearing problematic. An innovative scavenger introduced, Nanosweeper (NS), which utilizes nanostructure to facilitate transport NS-mtDNA co-assemblies for degradation, achieving clearance. fluorescent probe on NS, bound functional peptides, enhances stability NS. NS also exhibits robust human plasma with half-life up 10 hours. In murine model, serves as drug delivery vehicle, targeting inhibitor C-176 myocardium. This approach synergistically modulates cGAS-STING axis effectively attenuating myocarditis- associated inflammatory cascade. evaluation porcine models corroborated superior biosafety profile capability. strategic targeted couple inhibition, significantly augments therapeutic efficacy against myocarditis, outperforming conventional C-176, indicating potential.

Язык: Английский

Процитировано

0

Insights on the interactions between functionalized metal-polyphenol nanocarriers and human serum albumin via spectroscopic analysis DOI

Ning Hao,

Ruihong Lv,

Shanshan Gao

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106757 - 106757

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

Amplification of cGAS-STING Pathway with “Single-molecule Multitarget” Nanoparticles for Chemo-immunotherapy of Ovarian Cancer DOI

Huijiao Fu,

Xue Liu,

Fang Feng

и другие.

Biomaterials, Год журнала: 2025, Номер 323, С. 123434 - 123434

Опубликована: Май 24, 2025

Язык: Английский

Процитировано

0

Pyroptosis induced by natural products and their derivatives for cancer therapy DOI

Yingfei Wen,

You Li, Binbin Li

и другие.

Biomaterials Science, Год журнала: 2024, Номер 12(22), С. 5656 - 5679

Опубликована: Янв. 1, 2024

This review is focused on using natural products for cancer therapy by inducing pyroptosis-related signaling pathways. Natural product-based compounds can also be combined with other antitumor therapies a synergistic effect.

Язык: Английский

Процитировано

2

Nanomaterials evoke pyroptosis boosting cancer immunotherapy DOI Creative Commons
Zhenhua Li,

Ziyue Xi,

Chuanyong Fan

и другие.

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 15(2), С. 852 - 875

Опубликована: Ноя. 23, 2024

Cancer immunotherapy is currently a very promising therapeutic strategy for treating tumors. However, its effectiveness restricted by insufficient antigenicity and an immunosuppressive tumor microenvironment (ITME). Pyroptosis, unique form of programmed cell death (PCD), causes cells to swell rupture, releasing pro-inflammatory factors that can enhance immunogenicity remodel the ITME. Nanomaterials, with their distinct advantages different techniques, are increasingly popular, nanomaterial-based delivery systems demonstrate significant potential potentiate, enable, augment pyroptosis. This review summarizes discusses emerging field nanomaterials-induced pyroptosis, focusing on mechanisms pyroptosis pathways strategies activate or specific Additionally, we provide perspectives development this field, aiming accelerate further clinical transition.

Язык: Английский

Процитировано

1