Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication
Molecular Cancer,
Год журнала:
2024,
Номер
23(1)
Опубликована: Ноя. 30, 2024
In
the
realm
of
cancer
research,
tumor
microenvironment
(TME)
plays
a
crucial
role
in
initiation
and
progression,
shaped
by
complex
interactions
between
cells
surrounding
non-cancerous
cells.
Cytokines,
as
essential
immunomodulatory
agents,
are
secreted
various
cellular
constituents
within
TME,
including
immune
cells,
cancer-associated
fibroblasts,
themselves.
These
cytokines
facilitate
intricate
communication
networks
that
significantly
influence
initiation,
metastasis,
suppression.
Pyroptosis
contributes
to
TME
remodeling
promoting
release
pro-inflammatory
sustaining
chronic
inflammation,
impacting
processes
such
escape
angiogenesis.
However,
challenges
remain
due
interplay
among
cytokines,
pyroptosis,
along
with
dual
effects
pyroptosis
on
progression
therapy-related
complications
like
cytokine
syndrome.
Unraveling
these
complexities
could
strategies
balance
inflammatory
responses
while
minimizing
tissue
damage
during
therapy.
This
review
delves
into
crosstalk
elucidating
their
contribution
metastasis.
By
synthesizing
emerging
therapeutic
targets
innovative
technologies
concerning
this
aims
provide
novel
insights
enhance
treatment
outcomes
for
patients.
Язык: Английский
Manipulating the cGAS-STING Axis: advancing innovative strategies for osteosarcoma therapeutics
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 7, 2025
This
paper
explored
the
novel
approach
of
targeting
cyclic
guanosine
monophosphate
(GMP)-adenosine
(AMP)
synthase-stimulator
interferon
genes
(cGAS-STING)
pathway
for
treatment
osteosarcoma
(OS).
Osteosarcoma
is
a
common
malignancy
in
adolescents.
Most
patients
die
from
lung
metastasis.
It
reviewed
epidemiology
and
pathological
characteristics
OS,
highlighting
its
highly
malignant
nature
tendency
pulmonary
metastasis,
underscoring
importance
identifying
new
therapeutic
targets.
The
cGAS-STING
was
closely
associated
with
biological
behaviors
OS
cells,
suggesting
that
this
could
be
promising
strategy.
Currently,
research
on
role
has
been
limited,
underlying
mechanisms
remain
unclear.
Therefore,
further
investigation
into
exploration
strategies
based
are
great
significance
developing
more
effective
treatments
OS.
offered
fresh
perspective
providing
hope
options
by
pathway.
Язык: Английский
An Injectable Multifunctional Nanosweeper Eliminates Cardiac Mitochondrial DNA to Reduce Inflammation
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
Myocarditis,
a
leading
cause
of
sudden
cardiac
death
and
heart
transplantation,
poses
significant
treatment
challenges.
The
study
clinical
samples
from
myocarditis
patients
reveals
correlation
between
the
pathogenesis
cardiomyocyte
mitochondrial
DNA
(mtDNA).
During
inflammation,
concentration
mtDNA
in
cardiomyocytes
increases.
Hence,
it
is
hypothesized
that
combined
clearance
its
downstream
STING
pathway
can
treat
myocarditis.
However,
clearing
problematic.
An
innovative
scavenger
introduced,
Nanosweeper
(NS),
which
utilizes
nanostructure
to
facilitate
transport
NS-mtDNA
co-assemblies
for
degradation,
achieving
clearance.
fluorescent
probe
on
NS,
bound
functional
peptides,
enhances
stability
NS.
NS
also
exhibits
robust
human
plasma
with
half-life
up
10
hours.
In
murine
model,
serves
as
drug
delivery
vehicle,
targeting
inhibitor
C-176
myocardium.
This
approach
synergistically
modulates
cGAS-STING
axis
effectively
attenuating
myocarditis-
associated
inflammatory
cascade.
evaluation
porcine
models
corroborated
superior
biosafety
profile
capability.
strategic
targeted
couple
inhibition,
significantly
augments
therapeutic
efficacy
against
myocarditis,
outperforming
conventional
C-176,
indicating
potential.
Язык: Английский
Insights on the interactions between functionalized metal-polyphenol nanocarriers and human serum albumin via spectroscopic analysis
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 106757 - 106757
Опубликована: Март 1, 2025
Язык: Английский
Amplification of cGAS-STING Pathway with “Single-molecule Multitarget” Nanoparticles for Chemo-immunotherapy of Ovarian Cancer
Huijiao Fu,
Xue Liu,
Fang Feng
и другие.
Biomaterials,
Год журнала:
2025,
Номер
323, С. 123434 - 123434
Опубликована: Май 24, 2025
Язык: Английский
Pyroptosis induced by natural products and their derivatives for cancer therapy
Biomaterials Science,
Год журнала:
2024,
Номер
12(22), С. 5656 - 5679
Опубликована: Янв. 1, 2024
This
review
is
focused
on
using
natural
products
for
cancer
therapy
by
inducing
pyroptosis-related
signaling
pathways.
Natural
product-based
compounds
can
also
be
combined
with
other
antitumor
therapies
a
synergistic
effect.
Язык: Английский
Nanomaterials evoke pyroptosis boosting cancer immunotherapy
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
15(2), С. 852 - 875
Опубликована: Ноя. 23, 2024
Cancer
immunotherapy
is
currently
a
very
promising
therapeutic
strategy
for
treating
tumors.
However,
its
effectiveness
restricted
by
insufficient
antigenicity
and
an
immunosuppressive
tumor
microenvironment
(ITME).
Pyroptosis,
unique
form
of
programmed
cell
death
(PCD),
causes
cells
to
swell
rupture,
releasing
pro-inflammatory
factors
that
can
enhance
immunogenicity
remodel
the
ITME.
Nanomaterials,
with
their
distinct
advantages
different
techniques,
are
increasingly
popular,
nanomaterial-based
delivery
systems
demonstrate
significant
potential
potentiate,
enable,
augment
pyroptosis.
This
review
summarizes
discusses
emerging
field
nanomaterials-induced
pyroptosis,
focusing
on
mechanisms
pyroptosis
pathways
strategies
activate
or
specific
Additionally,
we
provide
perspectives
development
this
field,
aiming
accelerate
further
clinical
transition.
Язык: Английский