Biomedical Materials, Год журнала: 2024, Номер 19(6), С. 065025 - 065025
Опубликована: Окт. 2, 2024
Chemodynamic therapy (CDT) is a new method for cancer treatment that produces highly toxic reactive oxygen species (ROS) in the tumor microenvironment to induce cell apoptosis or necrosis. However, therapeutic effect of CDT often hindered by intracellular H
Язык: Английский
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 7, 2025
Abstract Metal‐protein hybrid materials represent a novel class of functional that exhibit exceptional physicochemical properties and tunable structures, rendering them remarkable applications in diverse fields, including engineering, biocatalysis, biosensing, biomedicine. The design development multifunctional biocompatible metal‐protein have been the subject extensive research key aspiration for practical clinical settings. This review provides comprehensive analysis strategies, intrinsic properties, biomedical these materials, with specific emphasis on their potential cancer therapy, drug vaccine delivery, antibacterial treatments, tissue regeneration. Through rational design, stable can be synthesized using straightforward methods, enabling therapeutic, immunomodulatory, other desired functionalities. Finally, outlines existing limitations challenges associated evaluates translation, providing insights into implementation within applications.
Язык: Английский
Процитировано
3
Science China Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 5, 2024
Язык: Английский
Процитировано
16
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159201 - 159201
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 297, С. 139557 - 139557
Опубликована: Янв. 6, 2025
Язык: Английский
Процитировано
1
Materials Today Bio, Год журнала: 2024, Номер 29, С. 101255 - 101255
Опубликована: Сен. 17, 2024
Язык: Английский
Процитировано
5
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Vanadium is a bioactive trace element with variable valence. Its pentavalent form has been confirmed to be capable of predominantly regulating the early and mid-stage osteogenic differentiation bone marrow mesenchymal stem cells (BMSCs) without tumor inhibition, while its tetravalent exhibits inhibition but only primarily modulates late angiogenesis. In this study, multifunctional tissue scaffold consisting mixed-valence vanadium-doped mesoporous glass poly(lactic-co-glycolic acid) (V(IV/V)-MBG/PLGA) was developed simultaneously inhibit recurrence osteosarcoma promote regeneration operative defects. The in vitro results showed that V(IV) V(V) species could sustainably released from V(IV/V)-MBG complementarily enhance proliferation, differentiation, mineralization BMSCs by activating multiple signaling pathways throughout whole osteogenesis process. More importantly, co-existence mixed-valent vanadium able continuously stimulate generation excessive ROS depletion GSH synergistically supplying an appropriate ratio thermodynamically kinetically maintain stable self-circulation valence state alteration, thus inducing UMR-106 cell death. rat model, V(IV/V)-MBG/PLGA scaffolds effectively suppressed invasion promoted regeneration. These suggest are promising strategy for treating tumor-associated defects, offering dual
Язык: Английский
Процитировано
0
Gels, Год журнала: 2025, Номер 11(3), С. 218 - 218
Опубликована: Март 20, 2025
Diffuse large B-cell lymphoma (DLBCL), accounting for 31% of non-Hodgkin lymphomas, remains recalcitrant to conventional therapies due chemoresistance, metastatic progression, and immunosuppressive microenvironments. We report a novel injectable Fe3O4@DMSA@Pt@PLGA-PEG-PLGA hydrogel system integrating magnetothermal therapy (MHT), chemodynamic (CDT), immunomodulation. Under alternating magnetic fields (AMF), the achieves rapid therapeutic hyperthermia (50 °C within 7 min) while activating pH/temperature-dual responsive peroxidase (POD) -like activity in Fe3O4@DMSA@Pt nanoparticles. Catalytic efficiency under tumor-mimetic conditions was significantly higher than Fe3O4@DMSA controls, generating elevated reactive oxygen species (ROS). Flow cytometry revealed 75.9% apoptotic cell death A20 cells at 50 °C, surpassing CDT alone (24.5%). Importantly, this dual mechanism induced immunogenic (ICD) characterized by 4.1-fold CRT externalization, 68% HMGB1 nuclear depletion, 40.74 nM ATP secretion. This triggered robust dendritic maturation (92% CD86+/CD80+ DCs comparable LPS controls) T activation (16.9% CD25+/CD69+ ratio, 130-fold baseline). Our findings validate potential magnetothermal-chemodynamic synergy DLBCL treatment, paving way innovative multi-mechanism strategies against with clinical translation prospects.
Язык: Английский
Процитировано
0
Materials Today Chemistry, Год журнала: 2025, Номер 45, С. 102702 - 102702
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Апрель 14, 2025
Targeted delivery of therapeutic agents to malignant tissues is crucial for enhancing clinical outcomes and reducing side effects. Magnetic nanorobots (MNRs) present a promising strategy controlled delivery, leveraging external magnetic fields achieve precise in vivo targeting. This work develops elongated MNRs comprising linearly arranged nanoparticles linked by metal-polyphenol complexes (MPCs) magnetic-field-directed active tumor targeting synergistic therapy. The are created assembling 30 nm Fe3O4 nanoparticles, tannic acid, ferrous ions (Fe2+) under uniform field, resulting chain-like structures fixed MPCs, which also promotes peroxidase-like activity. These show greater response than individual offering flexibility manipulation. MPCs coating allows tailored surface modifications with glucose oxidase, copper (Cu2+), human serum albumin (HSA), producing colloidally stable built-in multienzymatic cascade (MNRs@GOx/Cu/HSA) that consumes glucose, generates •OH, depletes the antioxidant glutathione (GSH). Collectively, surface-engineered multifunctional demonstrate improved driven fields, leading efficient localized chemodynamic structural functional properties developed render them suitable targeted cargo minimally invasive surgery, treatments disease sites.
Язык: Английский
Процитировано
0
Bioactive Materials, Год журнала: 2025, Номер 50, С. 540 - 555
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0