One-step synthesis of PtRhMo/Rh nanozymes for mitochondrial damage-mediated photothermal/enzymatic therapy DOI
Danyang Li, Enna Ha, Yaoyao Zhu

и другие.

Science China Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Язык: Английский

Integration of Motion and Stillness: A Paradigm Shift in Constructing Nearly Planar NIR-II AIEgen with Ultrahigh Molar Absorptivity and Photothermal Effect for Multimodal Phototheranostics DOI
Shiping Yang, Qian Jia, Xinwen Ou

и другие.

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

The two contradictory entities in nature often follow the principle of unity opposites, leading to optimal overall performance. Particularly, aggregation-induced emission luminogens (AIEgens) with donor–acceptor (D–A) structures exhibit tunable optical properties and versatile functionalities, offering significant potential revolutionize cancer treatment. However, trapped by low molar absorptivity (ε) owing distorted configurations, ceilings their photon-harvesting capability corresponding phototheranostic performance still fall short. Therefore, a research paradigm from twisted configuration near-planar structure featuring high ε is urgently needed for AIEgens development. Herein, introducing strategy "motion stillness" into highly planar A–D–A skeleton, we successfully developed near-infrared (NIR)-II AIEgen Y5-2BO-2BTF, which boasts an impressive 1.06 × 105 M–1 cm–1 photothermal conversion efficiency (PCE) 77.8%. modification steric hindrance on benzene ring acceptor unit aggregation-caused quenching counterpart Y5-2BO, meta-CF3-substituted naphthyl, leads reversely staggered packing various intermolecular noncovalent conformational locks Y5-2BO-2BTF ("stillness"). Furthermore, −CF3 moiety acted as flexible motion ultralow energy barrier, significantly facilitating process loose aggregates ("motion"). Accordingly, nanoparticles enabled tumor eradication pulmonary metastasis inhibition through NIR-II fluorescence-photoacoustic-photothermal imaging-navigated type I photodynamic-photothermal therapy. This work provides first evidence that conformation stacking arrangement could serve novel molecular design direction AIEgens, shedding new light constructing superior agents bioimaging

Язык: Английский

Процитировано

3
A new nanomaterial - carbonized polymer dots and their applications: A review DOI
Xiaoyu Li,

Chunyuan Kang,

Songyuan Tao

и другие.

Carbon, Год журнала: 2025, Номер unknown, С. 120122 - 120122

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Unlocking the potential of iridium-osmium carbolong conjugates: a high-performance photocatalyst for melanoma therapy DOI
Haobing Wang, Rongfang Wang, Shiyan Chen

и другие.

Science China Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Язык: Английский

Процитировано

0
Pillararene based supramolecular nanoplatform for endoplasmic reticulum-targeting type I photodynamic and NO gas therapy DOI

Shaoqi Xie,

Chang Liu,

Yue Cao

и другие.

Science China Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Язык: Английский

Процитировано

0
Expanding the Horizons of Phototherapy: A Review on the Superior Performance of Chalcogen‐Based Photosensitizers and Photothermal Agents for Cancer Therapy DOI Creative Commons
Subhrakant Jena,

Pranay Mohanty,

L. K. Dash

и другие.

ChemPhotoChem, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Phototherapy, encompassing photodynamic therapy (PDT) and photothermal (PTT), presents a promising cancer treatment strategy with high spatial specificity minimal invasiveness. Optimizing these techniques hinges on the design of high‐performance photosensitizers (PSs) agents (PTAs). Single‐atom chalcogen substitution, at both endocyclic exocyclic positions in conventional organic chromophores, has proven to be novel for enhancing their photophysical photochemical properties. Ideal PSs/PTAs exhibit biocompatibility, visible‐to‐near‐infrared (vis–NIR) absorption, efficient triplet state harvesting, feasible heat energy transfer efficiency. Moreover, chalcogen‐based show promise synergistic multimodal therapies, integrating imaging treatment. This review comprehensively examines recent advancements (within last five years) utilizing substitution robust PDT/PTT. It provides holistic perspective spectroscopic characterization computational analyses, singlet‐oxygen/triplet quantum yields, generation efficiency, vitro/in vivo biological evaluations chalcogen‐substituted PSs/PTAs. is anticipated that this will stimulate further research endeavors area.

Язык: Английский

Процитировано

0
Molecular fluorination strategy for regulating NIR AIEgens to boost phototheranostics of nasopharyngeal carcinoma DOI
Ping Zheng,

Yuxun Ding,

Alim Abdurahman

и другие.

Science China Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Язык: Английский

Процитировано

0
Indacenodithienothiophene-based A-D-A-type phototheranostics for immuno-phototherapy DOI Creative Commons

Yangtian Ye,

Shaojing Zhao,

E Pang

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Abstract The development of phototherapeutics with high photothermal conversion efficiency (PCE) and strong ability to generate reactive oxygen species under single near-infrared (NIR) laser irradiation for immuno-phototherapy applications remains a significant challenge. Herein, we optimally selected the molecule IT-4F an acceptor-donor-acceptor (A-D-A) structure prepare water-dispersible nanoparticles (NPs) by assembly DSPE-PEG-NH2. Such NPs have NIR absorption fluorescence peaks at 728 817 nm, respectively. They can singlet (1O2) superoxide anion (O2-·) irradiation, 1O2 generation quantum yield 31.5%. also effectively convert photon-energy into heat PCE 42.8%. outstanding properties enable them be used in imaging guided therapy (PTT), photodynamic (PDT). Moreover, PDT PTT triggered immunogenic cell death PANoptosis tumor cells, which not only inhibited growth metastasis mice model, but induced robust immune response, evidenced increased infiltration CD8+ T CD4+ dendritic decreased presence immunosuppressive cells such as myeloid-derived suppressor regulatory cells. efficacy organoid human breast cancer was verified.

Язык: Английский

Процитировано

0
Rational design and self-assembly of amphiphilic conjugated porphyrin small molecules for PDT/PTT synergistic therapy DOI

Binyu Zhao,

Haolan Li,

Cheng Li

и другие.

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142002 - 142002

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Mesoporous bowl-shaped polydopamine co-loaded temozolomide and indocyanine green for synergistically inhibiting glioblastoma DOI
Guangwei Zheng, Lei Ding,

Jingzheng Gan

и другие.

Science China Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
One-step synthesis of PtRhMo/Rh nanozymes for mitochondrial damage-mediated photothermal/enzymatic therapy DOI
Danyang Li, Enna Ha, Yaoyao Zhu

и другие.

Science China Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Язык: Английский

Процитировано

0